Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• treatment of leishmaniasis: pentavalent antimonials, amphotericin B, pentamidine, paromomycin, and miltefosine. Among these drugs, only the pentavalent antimonials were designed for leishmaniasis, while the other four were initially approved to treat other diseases. Although used in different treatment

• ]. Pentamidine-loaded nanoparticles also showed great results due to the nanostructure. Free pentamidine and Pentamidine-NPs were administered orally in an in vivo experimental model of mice infected with visceral leishmaniasis. Only the nanoencapsulated drug showed a significant reduction in the relative weight

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• 0.6–1.2 million new leishmaniasis cases appear annually [1]. The treatment for this disease involves using pentavalent antimonials, miltefosine, amphotericin B, paromomycin, or pentamidine. However, side effects of these drugs and an increased number of drug-resistant parasites have been reported [2

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• monometallic (nanoG) structures or core–shell bimetallic (nanoGS) architectures with an external silver layer. Here, we describe the preparation of a supramolecular assembly between nanoGS and pentamidine, an antileishmanial drug endowed with a wide range of therapeutic properties (i.e., antimicrobial, anti

• during the reduction/stabilization of metal NPs was investigated for the first time by NMR spectroscopy. Keywords: antimicrobial agents; bimetallic nanoparticles; gold/silver core–shell; Leishmania; pentamidine; polycyclodextrin; Introduction Noble metal nanoparticles (NPs), in particular those

• ) with pentamidine (Pent), an antimicrobial agent used against leishmaniasis [16], to investigate the antimicrobial activity of novel nanosystems (i.e., nanoGSP; Figure 1). Leishmaniasis is an infectious disease caused by protozoan parasites transmitted to humans and animals by the bite of tiny (2–3 mm