Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more

• efficiently than Di phytosomes after 72 h of incubation time by inducing cell cycle arrest and apoptosis. The results indicated that P2Ps could be a promising anticancer formulation for non-small-cell lung cancer. Keywords: diosgenin; non-small-cell lung cancer; phytosomes; sterol structure; Introduction

• analogues have a sterol structure that is very similar to cholesterol. It was reported that Di and lipids formed highly stable complexes at the air–water interface [18]. Therefore, Di and its derivatives could be substituted for cholesterol to form novel stable liposome-like phytosomes. The prepared

Association of aescin with β- and γ-cyclodextrins studied by DFT calculations and spectroscopic methods

• Ana I. Ramos,
• Pedro D. Vaz,
• Susana S. Braga and
• Artur M. S. Silva

Beilstein J. Nanotechnol. 2017, 8, 348–357, doi:10.3762/bjnano.8.37

• resource to controlled release strategies, which can be achieved by encapsulating aescin into liposomes [2][3], phytosomes (phospholipidic self-emulsifying particles) [10], zeolites [11], poly(lactic co-glycolic acid) nanoparticles [12] or cyclodextrins. Cyclodextrins are cyclic oligosaccharides, typically