Beilstein J. Nanotechnol.2020,11, 354–369, doi:10.3762/bjnano.11.26
Russian Academy of Sciences, 3, Ulan-Batorskaya St., P.O. Box 278, Irkutsk, 664033, Russia 10.3762/bjnano.11.26 Abstract The present work explores the ability of poly(1-vinylimidazole) (PVI) to complex small interfering RNA (siRNA) silencing vascular endothelial growth factor (VEGF) and the in vitro
that have been connected to the proliferation and invasion of lung cancer cells. These results indicate that the PVI complexes can be an effective agent to counter lung cancer.
Keywords: anti-VEGF siRNA; gene silencing; lung cancer; microarray; poly(1-vinylimidazole); small interfering RNA (siRNA
]. Several studies have explored the potential biomedical applications of PVI and its derivatives. Pullulan-grafted poly(1-vinylimidazole) was found complex anionic citrate and tripolyphosphate effectively in acidic medium via the imidazole moiety [8]. The catalytic properties of poly(1-vinylimidazole) due
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Figure 1:
(A) Gel retardation assay for polyplexes formed with different ratios (v/v) of PVI/siRNA. Ethidium ...