The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• ][112] covalently bonded to the polymer backbone. Otherwise, IR825 [101] has been used in the interior of the polymer micelles for photoacoustic (PA) imaging. Other photosensitizers proposed for image-guided PDT are ICG [78], TCPP [101] and pheophorbide a-conjugated poly(N-(2-hydroxypropyl

• )methacrylamide) when irradiated at 680 nm [92]. Besides, the chelating properties of porphyrins towards ions such as Mn2+ [101] or Gd3+ [80] or 64Cu [99] can be used for magnetic resonant imaging (MRI). Oxygen self-compensation. Local tumor hypoxia is one of the issues of PDT as the inefficient oxygen supply

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• Experimental Medicine CAS, Vídeňská 1083, 142 20 Prague 4, Czech Republic 10.3762/bjnano.9.236 Abstract Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal

• free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery. Keywords: cytotoxicity; doxorubicin; magnetic; nanoparticles; poly[N-(2-hydroxypropyl)methacrylamide]; Introduction Severe

• blood circulation time of the particles; however, it is often immunogenic [13]. As a better alternative to PEG, poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) was suggested, which was also used as a substitute for blood plasma [14]. Nevertheless, it has to be noted that nanotechnology in drug