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Search for "quality by design" in Full Text gives 4 result(s) in Beilstein Journal of Nanotechnology.

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

  • Daniel T. Pereira,
  • Douglas Dourado,
  • Danielle T. Freire,
  • Dayanne L. Porto,
  • Cícero F. S. Aragão,
  • Myla L. de Souza,
  • Guilherme R. S. de Araujo,
  • Ana Maria Costa,
  • Wógenes N. Oliveira,
  • Anne Sapin-Minet,
  • Éverton N. Alencar and
  • Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

Graphical Abstract
  • poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating P. setacea seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas
  • assays demonstrated high cell viability for ME at concentrations below 2 mg/mL in RAW 264.7 macrophages and 0.5 mg/mL in human umbilical vein endothelial cells. Overall, this work presents a promising nanotechnology-based topical delivery platform for P. setacea seed oil, employing quality by design
  • principles to ensure formulation performance, stability, and skin cell compatibility. Keywords: design of experiments (DoE); microemulsions; nanotechnology; natural products; passion fruit; quality by design; skin delivery; Introduction Species of the Passiflora genus are known for their rich composition
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Published 20 Nov 2025

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

  • Iqra Rahat,
  • Pooja Yadav,
  • Aditi Singhal,
  • Mohammad Fareed,
  • Jaganathan Raja Purushothaman,
  • Mohammed Aslam,
  • Raju Balaji,
  • Sonali Patil-Shinde and
  • Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

Graphical Abstract
  • against MDA-MB-435s cells. Further, the targeted PLHNPs also showed better cytotoxic effects against MCF-7 cells. In another study, Ma et al. fabricated HCT-loaded PEGylated PLHNPs and optimized them by the “Quality by Design” approaches such as Plackett–Burman and Box–Behnken designs [127]. The developed
  • CHS-based mucoadhesive PLHNPs in improving PRN’s intestinal permeation, oral bioavailability, and anti-BC activity [154]. The developed PLHNPs were optimized by the “Quality by Design” approach. The optimized PRN-PLHNPs were stable in the GI milieu and showed excellent mucoadhesive strength and
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Published 22 Nov 2024

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

  • Horacio Emanuel Jerez,
  • Yamila Roxana Simioni,
  • Kajal Ghosal,
  • Maria Jose Morilla and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

Graphical Abstract
  • increasingly pursued “quality by design” criteria [24]. The development of structurally simple formulations that facilitate their scaling and further characterization is, therefore, a critical task [25]. Also, targeting nanomedicines to circulating cells and vascular walls is difficult since it should occur
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Published 13 May 2024

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

  • Hsuan-Ang Tsai,
  • Tsai-Miao Shih,
  • Theodore Tsai,
  • Jhe-Wei Hu,
  • Yi-An Lai,
  • Jui-Fu Hsiao and
  • Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

Graphical Abstract
  • smaller particle size. In addition, we used Quality by design (QbD) to generate parameters that can be applied to commercial products in the future. The QbD is a systematic approach to drug development that ensures that a product is of high quality and consistently meets the desired characteristics
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Published 25 Apr 2024
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