Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

• Alina M. Ermakova,
• Julia E. Morozova,
• Yana V. Shalaeva,
• Victor V. Syakaev,
• Aidar T. Gubaidullin,
• Alexandra D. Voloshina,
• Vladimir V. Zobov,
• Irek R. Nizameev,
• Olga B. Bazanova,
• Igor S. Antipin and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

• and Discussion Synthesis and characterization of tetraundecylcalix[4]resorcinarene–mPEG conjugate To obtain the amphiphilic calixresorcinarene, tetraundecylcalix[4]resorcinarene 1 was functionalized with tosylated mPEG-550 (2) (Scheme 1). The obtained macrocycle 3 was characterized by 1H NMR, 13С NMR

• the NMR time scale and, consequently, to the broadening of the signals of calixresorcinarene platform in the NMR spectra. The same broadening in the spectra of tetraundecylcalix[4]resorcinarene with poly-ε-caprolactone fragments on the upper rim was described earlier [22]. In the FTIR spectrum of 3

• tetraundecylcalix[4]resorcinarene–mPEG conjugate 3. Hemolytic activity data of 3 against human red blood cells (hRBC) in 0.15 M NaCl. Data of substrate encapsulation in micelles of 3; log Pa: octanol–water partition coefficient of the substrates; m3: mass of 3 (mg); mS0: initial mass of the substrate (mg); mS1

Closed polymer containers based on phenylboronic esters of resorcinarenes

• Tatiana Yu. Sergeeva,
• Rezeda K. Mukhitova,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Polina D. Klypina,
• Albina Y. Ziganshina and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 1594–1601, doi:10.3762/bjnano.9.151

• resorcinarene (SRA) with phenylboronic acid. p(SRA-B) shows good stability in water and can be used as a nanocontainer for the pH- and glucose-controlled substrate release. Fluorescent dyes (fluorescein, pyrene and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt) were successfully loaded into p(SRA-B). The

• release of dye is achieved by lowering the pH value to 3 or by adding glucose. Keywords: boronic acid; polymer nanocontainer; resorcinarene; responsive release; Introduction Boronic acids effectively interact with diols [1][2][3][4] that have found application in various fields: in the recognition and

• functional groups and various stimulus-responsive fragments allows one to create diverse responsive systems. Earlier we constructed and reported thermo- and redox-responsive nanocontainers based on the resorcinarene cavitand [36][37]. Continuing these works we designed a new nanocontainer using resorcinarene