In search of cytotoxic selectivity on cancer cells with biogenically synthesized Ag/AgCl nanoparticles

• Mitzi J. Ramírez-Hernández,
• Mario Valera-Zaragoza,
• Omar Viñas-Bravo,
• Ariana A. Huerta-Heredia,
• Miguel A. Peña-Rico,
• Erick A. Juarez-Arellano,
• David Paniagua-Vega,
• Eduardo Ramírez-Vargas and
• Saúl Sánchez-Valdes

Beilstein J. Nanotechnol. 2022, 13, 1505–1519, doi:10.3762/bjnano.13.124

• amount of phenolic compounds in the pineapple peel extract was quantified. The total phenolic content (TPC) in the pineapple peel extract was 24.66 ± 1.03 mg Catechin/g Ext, and the total flavonoid content (TFC) was 0.62 ± 0.21 mg Rutin/g Ext. The extract has a higher phenolic content in comparison to

Preservation of rutin nanosuspensions without the use of preservatives

• Pascal L. Stahr and
• Cornelia M. Keck

Beilstein J. Nanotechnol. 2019, 10, 1902–1913, doi:10.3762/bjnano.10.185

• in assays, cell cultures or animal models. Therefore, to enable an easier use of nanocrystals, preservative-free nanosuspensions would be a good alternative. In this study, rutin nanocrystals were frozen and stored for three months at −20 °C. The chemical, physical and microbial stability were

• -term stability. The freeze–thaw process for nanosuspensions is a simple concept and is suggested as alternative, when preserved nanosuspensions cannot be used. Keywords: nanocrystals; nanosuspension; no preservative; rutin; stability; Introduction Nanocrystals for pharmaceutical use were invented in

• freeze–thaw method is suitable for the production of long-term stable non-preserved nanosuspensions with high microbial quality, previously developed nanosuspensions containing the flavonoid rutin as model substance and either Plantacare 2000 or Poloxamer 188 (PLX 188) as stabilizers were produced by

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

• David Hespeler,
• Sanaa El Nomeiri,
• Jonas Kaltenbach and
• Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

• addition, a scalable production process was demonstrated. The loading of the particles was performed by applying the immersion–evaporation method. The antioxidant rutin was used as a model active agent and ethanol was applied as the solvent. Various silica particles (Syloid®, Davisil®) differing in

• solvent removal) can be industrially realized in a commercial 50 L rotary evaporator. Keywords: amorphous dispersion; bioavailability enhancement; dermal delivery system; rutin; smartPearls; solubility enhancement; Introduction Many interesting active agents in pharma and cosmetics are poorly soluble

• ., rutin, hesperidin), which are presently en vogue in cosmetics for antipollution products (e.g., the “molecular barrier” against reactive oxygen species (ROS), infrared (IR) radiation and blue light from computers) [1][2]. For the delivery of such molecules, efficient delivery systems are the only