Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• innovative biomedical strategies mainly in the field of anticancer therapy. Keywords: nucleopeptides; poly(rA) binders; RNA; self-structures; Review Polyadenylation in RNA processing Polyadenylation is part of the RNA processing pathway that leads to the production of mature mRNA molecules (Figure 1) [1

• helix poly(rA) structures induced at low pH conditions. Recent reports on poly(rA) binding activity of the plant alkaloid chelerythrine (Figure 3) indicated that this natural compound was also able to induce poly(rA) self-structures with the formation of a poly(rA) helix that showed a cooperative

• other artificial compounds such as ethidium salts, quinacrine, and proflavine proved to be efficient binders of single-stranded poly(rA) capable of inducing self-structures of such RNA. This characteristic is absent in the compound Hoechst 33258 that acts as a poly(rA) binder, but is unable to provoke