Beilstein J. Nanotechnol.2019,10, 1666–1678, doi:10.3762/bjnano.10.162
Berlin, Germany Institute of Functional Interfaces, Karlsruher Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany 10.3762/bjnano.10.162 Abstract smartPearls are a dermal delivery system for poorly soluble active agents, consisting of nanoporous silica
. Based on a 10% (w/w) loading and the amorphous solubility of the active agent, for a 100 kg dermal formulation, about 500 g of loaded particles were required. This corresponds to production of 5 kg of loaded smartPearls for a formulation batch size of a ton. The production of 5 kg (i.e., about 25 L of
solvent removal) can be industrially realized in a commercial 50 L rotary evaporator.
Keywords: amorphous dispersion; bioavailability enhancement; dermal delivery system; rutin; smartPearls; solubility enhancement; Introduction
Many interesting active agents in pharma and cosmetics are poorly soluble
PDF
Figure 1:
From left to right: rutin/ethanol solution, silica dispersed in rutin solution attached to the rota...