Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte

• /biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative. Keywords: layer-by-layer self-assembly; pH-triggered release; PLGA nanoparticles; polyelectrolyte multilayers; weak polyelectrolyte; Introduction The

• , polyelectrolyte multilayers have already in various cases been applied for pH-driven release, based on weak polyelectrolyte components [22][23][24][25][26][27]. Nanoparticles can be used as carrier systems for the transport of drugs to cells and tissues. Once getting in contact with cells nanoparticles can be

• , which could be attributed to successful adsorption of the cationic PEI layer. pH-Sensitivity of the PAA layer in dependence on the adsorption pH value PAA, as a weak polyelectrolyte with a charge density depending on pH, can be easily adsorbed onto positively charged substrates, such as PLGA