Stimuli-responsive polypeptide nanogels for trypsin inhibition

• Petr Šálek,
• Jana Dvořáková,
• Sviatoslav Hladysh,
• Diana Oleshchuk,
• Ewa Pavlova,
• Jan Kučka and
• Vladimír Proks

Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45

• Science, Charles University, Hlavova 8, 128 40 Prague 2, Czech Republic 10.3762/bjnano.13.45 Abstract A new type of hydrophilic, biocompatible, and biodegradable polypeptide nanogel depots loaded with the natural serine protease inhibitor α1-antitrypsin (AAT) was applied for the inhibition of the

• trypsin because they contain suitable amino acids in their structures that effectively block the active site of trypsin. Keywords: α1-antitrypsin; inflammatory mediator; nanogel; polypeptide; trypsin; Introduction Despite significant and progressive advances in medicine, the global incidence of

• other serine proteases inhibitors, such as α1-antitrypsin (AAT), α2-macroglobulin, α1-antichymotrypsin, and eglin C [11]. However, direct intravenous or oral administration of the majority of these natural serine protease inhibitors is ineffective due to their low plasma and peritoneal levels, very