Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• to evade the immune system, such as expressing immunosuppressive molecules and creating a hostile tumor microenvironment that suppresses antitumor activity [7]. One of the most exploited mechanisms by tumors involves immune checkpoints, such as PD-L1 (programmed death-ligand 1) and CTLA-4 (cytotoxic

• inhibition of cancer cell migration, invasion, and metastasis [122][123]. The patent characterizes the NPs through DLS and TEM, confirming a uniform size distribution. Additionally, in vitro studies using MCF-7 breast cancer cells demonstrated inhibition of cell proliferation, with the NP inducing apoptosis

• ]. The formulation includes temperature-responsive and non-temperature-responsive amphiphilic molecules (weight ratio of 7:3). UV–vis spectroscopy, TEM, and DLS experiments demonstrated that administration of 14.37 mg·kg−1 of the nanoparticles inhibited lung adenocarcinoma proliferation and migration

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• a Brazilian scorpion species with great medical significance [2][5], responsible for the highest number of accidents and also the most severe ones [6][7]. Scorpion toxins represent a vast collection (≈100,000) of pharmacologically relevant peptide toxins that have provided an important foundation

• for advancing the studies in this field [8]. Tityus serrulatus venom is comprised of several compounds such as mucus, salts, proteins with high molecular mass, nucleotides, lipids, amino acids, hyaluronidase, hypotension factors, metalloproteases, and neurotoxins [7][9]. However, neurotoxins are

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• disposal stages [6]. The tiny MP particles can directly harm marine life through ingestion or indirectly by attracting and accumulating environmental pollutants [7]. Experimental studies show that exposure to MPs can result in a wide range of harmful effects such as disruptions in metabolism, oxidative

• wastewater varies, with levels reaching several hundred particles per litre [7]. Studies have reported significant variation in the concentration and types of MPs present in wastewater samples collected from different treatment plants. Commonly identified MPs include polyethylene (PE, 4–51%), polyester (PES

• , including MPs [86]. Figure 7 illustrate the various types of nanoadsorbents used for MP removal, while Table 3 present their operational conditions and corresponding removal efficiencies for different types of MPs. Nanoparticle-based photocatalysis: Catalytic or photocatalytic oxidation, categorized under

Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe–host interface

• Lina M. Rojas González,
• Naeim Ghavidelnia,
• Christoph Eberl and
• Max D. Mylo

Beilstein J. Nanotechnol. 2025, 16, 1592–1606, doi:10.3762/bjnano.16.113

• toughness along a specific direction or within a defined volume [7]. By strategically varying the composition or morphology of the material, FGMs can be designed with enhanced performance characteristics tailored to specific application requirements. The gradient can be continuous or discontinuous, or step

• found for the specimen with V-shaped interfaces (Figure 6D). Functionally graded metamaterials To analyze the mechanical metamaterials, three different geometries were tested under tension, one with a triangular metastructure and two with a graded PP–PPGF metastructure (Figure 2G–I). Figure 7 shows the

Few-photon microwave fields for superconducting transmon-based qudit control

• Irina A. Solovykh,
• Andrey V. Pashchenko,
• Natalya A. Maleeva,
• Nikolay V. Klenov,
• Olga V. Tikhonova and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1580–1591, doi:10.3762/bjnano.16.112

• algorithms. A promising solution to this problem is to expand the computational basis of an element by switching to qutrits (n = 3), ququarts (n = 4), and so on [7][8][9][10][11][12]. We believe that an additional synergistic effect can be achieved by using quantum electromagnetic fields with a comparable

• field mode, the analytical solution of the problem is found. In the general case, the nonstationary Schrödinger equation (Equation 7) was solved numerically using the expansion of the total non-stationary wave function in terms of the interaction-free eigenfunctions of the Josephson, ϕn, and field

• , , subsystems: where the designation of the total energy in the system is Substituting the solution in Equation 9 into Equation 7 leads to a system of differential equations for probability amplitudes Cn,k(t) to find k photons in the field mode and n-fold excitation of the transmon: Based on the obtained

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• and engineering. Conventional treatment approaches, including adsorption, membrane separation, and biological methods, are largely inadequate for antibiotics such as OFL [6][7]. This limitation highlights the need for advanced oxidation processes, with a particular emphasis on TiO2-based

• degradation, as explained by (Equation 5): Above the critical concentration, H2O2 primarily serves as an electron acceptor (Equations 6 and 7), generating additional OH• radicals via reactions with superoxide radicals (O2•–) or photogenerated electrons (e–) [28], demonstrated by the subsequent reactions

Modeling magnetic properties of cobalt nanofilms used as a component of spin hybrid superconductor–ferromagnetic structures

• Aleksey Fedotov,
• Olesya Severyukhina,
• Anastasia Salomatina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2025, 16, 1557–1566, doi:10.3762/bjnano.16.110

• Engineering Department, Kalashnikov Izhevsk State Technical University, Studencheskaya 7, Izhevsk 426069, Russia Institute of Electronic Engineering and Nanotechnologies, Technical University of Moldova, 3/3 Academiei St., Chisinau, 2028, Moldova Moscow Institute of Physics and Technology, 9, Institutskiy per

• technologies [5][6][7] based on Josephson junctions. It is well established that the properties of nanostructures can significantly differ from those of bulk samples. Currently, close attention is paid to thin-film magnetic structures, which include cobalt and iron [8][9][10]. Thus, in [1], the crystal

• moments of its atoms are shown in Figure 1. Periodic boundary conditions were applied to the computational cell along all coordinate directions. The system was symmetric along all coordinate axes. The magnetic parameters of the exchange integral (Equation 7) were also chosen according to [22]. The

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• focused on the development of implants that can naturally resorb within the body, thereby eliminating long-term retention and minimizing adverse biological responses [5]. This paradigm is particularly attractive in clinical scenarios such as neurorehabilitation [6][7][8], gastric recovery [9], cardiac

• , making them ideal candidates for next-generation biomedical implants that are designed to function for a limited period, such as for temporary rehabilitation or short-term therapeutic purposes following surgery [6][7][8][10][14][21][22][23][24][25][26][27][28][29][30]. Clinically relevant implementations

• wireless, fully bioresorbable electrical stimulator designed to promote nerve regeneration during the initial phase of neural injury treatment and subsequently undergo complete degradation [7] (Figure 1b), battery-free and bioresorbable pacemakers designed for on-demand cardiac rhythm management during the

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• become an emerging field of research [3][4][5][6][7]. The expanding application areas require silicon nanomaterials of different morphologies, including quantum dots, nanowires, and nanocrystalline films. Si nanowires, for example, are considered as a promising alternative to silicon electrodes in Li-ion

• electrical properties suitable for a wide range of practical applications [7][8][9]. PLAL has a number of advantages over other NP production methods due to the accessibility of equipment for ablation, the simplicity of the method, which does not require a special environment such as vacuum, and the ability

• , operating at 1064 nm (energy 80 mJ per pulse, repetition rate 10 Hz, pulse duration 10 ns, laser beam diameter 6 mm, ablation time 20 min) in a double-pulse mode with an interpulse delay of 1 μs [7][10]. These parameters were maintained for all three cases of focusing optics forming spatial profiles of

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• metal contamination. Consequently, the efficient removal of heavy metal ions remains a critical research challenge. Various methods have been employed including membrane filtration [1], flocculation [2], adsorption [3][4], precipitation [5], electrolytic removal [6], ion exchange [7], reduction [8], and

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• IONPs, using either amine- or carboxylic acid-functionalized IONPs, especially when biomolecules, such as proteins or peptides, are involved [3][7][8][9][10][11][12][13][14]. Sharpless et al. [6] have generally defined “click chemistry” as chemical processes that are highly selective, have a high

• , in these experiments, PPA was added to a final concentration of 180 mM, which falls in the upper region of the typical amine concentrations used in the literature (≈0.1–300 mM) [7][13]. To demonstrate that our results are not simply an artifact of the higher amine concentration used, we performed a

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• strength, more effective functioning, and biological compatibility [7]. Nanomaterials play a leading role in drug delivery and gene transportation. Older methods for drug delivery usually do work well, miss their intended targets, and cause unwanted side effects. Nanotechnology helps with this challenge by

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• 2004 [2][4][5][6][7][8][9] offer insights into its history, novelties, mechanisms, and applications, catering to the interests and choices of readers [10]. A list of recent review articles highlighting advancements in laser ablation, processing, and structuring of different materials, along with a

• examples of nanoparticle synthesis by laser ablation were discussed [7]. They have clearly depicted how the properties of the nanoparticles (NPs) depend strongly on size, shape, and size uniformity. Pulsed laser ablation in liquids (PLAL) is a promising method for producing pristine and supported materials

• films of copper phthalocyanine (CuPc) doped with laser generated Au and Ag NPs were prepared using spin coating on glass substrates. Transmission electron microscopy analysis indicated spherical NPs having sizes in the range of 7–43 nm for Au NPs, and 12–50 nm for Ag NPs. The deposited films had good

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• , photochemical methods utilizing physical agents such as lasers [5], UV light [6], or LEDs [7][8][9] have gained attention due to their superior spatial and temporal control, high stability of the resulting AgNPrs and avoidance of environmentally unfriendly reducing agents [8][10]. The strong surface plasmon

• spectra of the AgNPs seed shown in the Figure 1a displayed a single peak at 400 nm, indicating the presence of spherical silver nanoparticles with small sizes, consistent with studies in the literature [4][6][7]. The sample exhibited the characteristic yellow color of AgNPs. The TEM image and size

• nanostructures had occurred at this stage [4][7]. The IPD peak was still observed after 12 and 24 h but with progressively decreasing intensity, suggesting a reduction in the number of spherical silver seeds as the irradiation time increased. After 12 h, in addition to the IPD peak at 405 nm, a broad shoulder

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• Yan’an, China, MP concentrations in agricultural soils reached 4505 ± 435 ng/kg, with polyethylene (PE) accounting for 37.4% of the total [7]. Similarly, in the United Kingdom, plastic-mulched soils contained 3680 ± 129.1 particles/kg, while non-mulched soils exhibited lower levels at 2667 ± 84.1

• ecological pollution in agricultural soils [7]. In contrast, wastewater systems in Oman exhibited polymer indices ranging from moderate to extreme danger, emphasizing the need for enhanced MP removal technologies [12]. These findings highlight the pervasive nature of MP contamination across terrestrial and

• illustrates the effectiveness of biochar in counteracting the physical degradation caused by MPs. In terms of soil chemical properties, MPs influence pH, organic matter content, and macronutrient levels, including nitrogen (N), phosphorus (P) and potassium (K). For example, 3–7% low-density polyethylene (LDPE

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• , with diameters ranging from 0.4 to 100 nm and lengths extending from a few micrometers to several centimeters [7]. The functionalization of CNTs is achieved by surface modification through various methods including covalent bonding, adsorption, and detection group attachment [7][8]. Palve et al

• vertical) in this deposition chamber with Kapton tape. 0.5 g of parylene-C powder was placed in a ceramic boat (7 cm × 1.5 cm × 1 cm), which was used in the deposition process. The system was first evacuated to a pressure below 1.33 Pa. Next, the valve heating tape and tube furnace were activated. Once the

• was turned off and the deposition chamber was opened after the system had cooled down to room temperature. Laser-assisted nanowire tip exposure A focused 450 nm blue diode laser beam was used to expose the tip of the platinum nanowires after parylene-C coating. Figure 7 illustrates the experimental

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• are located in glaciers, the atmosphere, and soil; rendering them difficult to access and utilize [5][6][7]. To tackle the challenge of clean water scarcity, desalination of seawater or brackish water have emerged as effective solutions [1][8][9]. According to the literature, desalination technologies

Automated collection and categorisation of STM images and STS spectra with and without machine learning

• Dylan Stewart Barker and
• Adam Sweetman

Beilstein J. Nanotechnol. 2025, 16, 1367–1379, doi:10.3762/bjnano.16.99

• results [4][5][6][7]. STS measurements are the result of an integration over the available density of states (DOS) in both the tip and the sample, with the current measured therefore being proportional to the convolution of two. To isolate the DOS of the sample, it is crucial that the tip has a nominally

• shown in Figure 7, where it can be clearly seen that there is a peak at roughly 0.8 V, which is not present in the bare surface spectra seen in Figure 3c. Previous STS data of SnDown molecules show a clear increase in conductance at both −0.85 and 0.75 V when imaging at a setpoint of 50 pA [22]. These

• HOMO from the literature value of 0.75 V to our consistent measurement of roughly 0.8 V. In addition, the work also suggests a current dependence on the position of the HOMO, which could be a contributing factor to the difference. When comparing the “good” spectra taken over the molecules (Figure 7

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• themselves through plasmids, promoting the rapid spread of antimicrobial resistance [6]. In this regard, the abuse of antibiotics in livestock and agriculture has been identified as one of the main factors that have led to the emergence of AMR [7]. The emergence and spread of AMR has intensified the interest

• ]. Dellera et al. developed wound dressings containing silver sulfadiazine 7 and platelet lysate encapsulated in SLNs to treat persistent skin lesions. The Ag-encapsulating SLNs were prepared using ultrasound and hot homogenization techniques and incorporated into chitosan glutamate or hydroxypropylmethyl

• higher light absorption, and greater photoemission output, resulting in enhanced bactericidal activity against S. aureus (Figure 7). The Ir-complex liposomes interact efficiently with 450 nm LED light, leading to ROS generation and subsequent bacterial inactivation at the site of an infected chronic skin

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• accumulation of lipid ROS. Ferroptosis clearly differs from necrosis, apoptosis, and autophagy in terms of cellular morphology and function [7]. Recently, studies have indicated that ferroptosis can be utilized for cancer therapy since it effectively eliminates cancer cells and reverses drug resistance [8][9

• inducing ferroptosis through various pathways to enhance cancer therapy. We also discuss stimuli-responsive liposomes and evaluate their effects on the immune system. 2 Ferroptosis A recently recognized regulated condition of iron-dependent cell death is called ferroptosis [7][22]. The Latin term “ferrum

• and aspartate, while in glial cells xag− system can also transport cysteine [71][72]. The xc− system is a transmembrane transport protein with a high affinity for cysteine, composed of Solute Carrier Family 7 Member 11 (SLC7A11) and Solute Carrier Family 3 Member 2 (SLC3A2) as a heterodimer and plays

Deep-learning recognition and tracking of individual nanotubes in low-contrast microscopy videos

• Vladimir Pimonov,
• Said Tahir and
• Vincent Jourdain

Beilstein J. Nanotechnol. 2025, 16, 1316–1324, doi:10.3762/bjnano.16.96

• , finding numerous applications in scientific research. Deep learning models have been used to identify two-dimensional materials in microscopic images [6], characterize mineral composition in scanning electron microscopy (SEM) samples [7], and determine nanotube chirality from transmission electron

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• promising alternative to high-precision lithography techniques [1][2][3]. The utilization of short femtosecond laser pulses has proven instrumental in overcoming diffraction limit restrictions, enabling controlled fabrication of periodic subwavelength structures [4][5][6][7][8][9]. This controlled

• pure metals [70][71][72]. Figure 7 displays cross-sectional surface morphology images for samples irradiated with 600, 1200, 2000, 2200, and 2400 nm laser wavelength. As depicted in Figure 8 and Table 2, the diagram reveals a contradiction to the established principle of skin depth, as the depth of

Enhancing the photoelectrochemical performance of BiOI-derived BiVO₄ films by controlled-intensity current electrodeposition

• Huu Phuc Dang,
• Khanh Quang Nguyen,
• Nguyen Thi Mai Tho and
• Tran Le

Beilstein J. Nanotechnol. 2025, 16, 1289–1301, doi:10.3762/bjnano.16.94

• absorption, moderate bandgap (≈2.4 eV), high theoretical photocurrent density (≈7.5 mA·cm−2), and chemical stability in aqueous environments [7][8][9]. Nevertheless, BiVO4 suffers from intrinsic drawbacks such as low charge carrier mobility, limited conductivity, and rapid recombination of photogenerated

• ) were used to adjust the pH during deposition. Ethanol (C2H5OH, 99.9%, Merck) and deionized (DI) water were used for cleaning and dilution, respectively. Fluorine-doped tin oxide (FTO) glass substrates (7 Ω·sq−1, Pilkington) served as the conductive support for electrodeposition. Fabrication of BiVO4

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• the regional culture [3][4]. Bocaiúva oil contains several antioxidant compounds such as phenols, terpenes, β-carotenes, and compounds that present antioxidant properties [5][6]. It contains free fatty acids, monoglycerides, triglycerides, sterols [6][7][8], and saturated and unsaturated fatty acids

• consistent with findings by Hiane and collaborators [40] and Lieb and collaborators [7], who also observed a high concentration of monounsaturated fatty acids in the fruit pulp. Amaral et al. further identified a notable oleic acid content of 69.07% in Acrocomia aculeata pulp oil [41]. Minor discrepancies in

• . Formation of experimental groups and induction of paw edema Eight experimental groups were randomly formed, with five animals per group (n = 5). 30 min before edema induction, groups 3, 4, 5, 6, 7, and 8 received the test substances (diclofenac sodium, AAO, or AANE). Group 1 received a blank (obtained under

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• altered metabolic responses inevitably leads to treatment failure [5][6][7]. Anyhow, an early detection of cancer enhances treatment success and increases survival. However, monotherapies proved limited therapeutic efficacy. Thus, an effective multiple cancer therapeutic regimen has been employed to

• metastatic breast cancer (Figure 7) [128]. The nanosystem was modified with TAT (T) and RGD (R) peptides for targeted delivery of the chemotherapeutics gamabufotalin (C) and doxorubicin (DOX) in triple-negative breast cancer (TNBC), resulting in potent inhibition of tumor growth and breast cancer metastasis