Microneedles for vaccination and drug delivery
Microneedles made from a range of materials including silicon, metals and polymers have considerable potential for inexpensive disposable patch delivery of drugs and vaccines. The design of robust microneedle arrays for reliable skin penetration, with or without applicators, cost-effective manufacture, and drug and vaccine storage strategies such as dissolving microneedle tips are some of the key areas of current R&D.
Contributions to the thematic issue are invited, including but not limited to, the following topics:
- Microneedle design
- Microneedle materials
- Novel materials: hydrogels, dissolving formulations
- Microneedle manufacturing processes and scale-up potential
- Skin penetration modelling and experiments
- Controlled insertion applicators
- Applications R&D including preclinical and clinical studies using microneedle arrays
** Submission deadline extended to February 28, 2023 **
- Full Research Paper
- Published 08 Jun 2022
-
PDF -
Album-
![]()
Figure 1: Micrographs obtained by optical microscopy showing the structure of the microneedles containing eth...
-
![]()
Figure 2: Micrographs obtained by optical microscopy showing the structure of microneedles containing glycoli...
-
![]()
Figure 3: Micrographs obtained by scanning electron microscopy (SEM) showing the surface morphology microneed...
-
![]()
Figure 4: Micrograph obtained by scanning electron microscopy (SEM) showing the surface morphology of microne...
-
![]()
Figure 5: Response surface plots for height and base measurements of MNs containing EE or GE. The color scale...
-
![]()
Figure 6: Response surface plots for force and compression area of MNs containing EE or GE. The color scale i...
-
![]()
Figure 7: Schematic representation for the analysis of the height and base measurements of the microneedles.
-
-
Supp. Info
- Full Research Paper
- Published 15 Jun 2022
-
PDF -
Album-
![]()
Figure 1: Microneedle fabrication using the two-layer centrifugation method. PVA/PVP or PVA gel with ciproflo...
-
![]()
Figure 2: Schematic presentation of the skin deposition study of CIP_MN1. The full-thickness human skin was e...
-
![]()
Figure 3: In vitro model for the antimicrobial activity of CIP_MN1. Preincubated inoculum of S. aureus is str...
-
![]()
Figure 4: Microneedle visualization for two formulations; (a) CIP_MN1 images under digital light microscope, ...
-
![]()
Figure 5: (a) Parafilm penetration with CIP_MN1 microneedles; (b) artificial skin (agarose-based) penetration...
-
![]()
Figure 6: (a) CIP_MN1 dissolution in excised human skin over time (represented by CIP_MN1 height decease with...
-
![]()
Figure 7: Ciprofloxacin skin deposition from CIP_MN1 after 1 h and 12 h from insertion, and from free gel aft...
-
![]()
Figure 8: Antibacterial activity of CIP_MN1 applied on an in vitro skin model mounted on S. aureus-inoculated...
-
- Full Research Paper
- Published 08 Jul 2022
-
PDF -
Album-
![]()
Figure 1: Laboratory scale process for hot embossing of COP MN array replicas using a rheometer. a) Master MN...
-
![]()
Figure 2: a) Skin stretching mechanism used to mimic skin condition in vivo. The skin sample is placed on the...
-
![]()
Figure 3: SEM images of length, tip size, and diameter of the a) BD Ultra-Fine™ 4 mm Pen Needle and b) thermo...
-
![]()
Figure 4: SEM of the 9 × 9 MN array, a) master MN array fabricated by TPP, b) replicated thermoplastic MN arr...
-
![]()
Figure 5: a) SEM of a MN after compression test, showing effects due to buckling and near tip failure indicat...
-
![]()
Figure 6: a) 2D axisymmetric meshing for three-layer skin model and single MN model, b) von-Mises stress resu...
-
![]()
Figure 7: Confocal images of cryo-sectioned porcine back skin showing MN array penetration: a) control test w...
-
- Review
- Published 24 Oct 2022
-
PDF -
Album-
![]()
Figure 1: Microneedle classification criteria.
-
![]()
Figure 2: A schematic representation of five different MN types used to facilitate transdermal drug delivery....
-
![]()
Figure 3: Illustrated examples of techniques used to coat MNs. (a) Dip coating. (b) Gas-jet drying. (c) Spray...
-
![]()
Figure 4: Stereomicroscopic image of the microneedle patch (e) and magnification of the microneedles (f), sca...
-
![]()
Figure 5: Microscopic image of dissolving MNs manufactured by Albadr and co-workers. Figure 5 was reproduced from [176] (©...
-
![]()
Figure 6: Microscopic image of the MNs obtained by Amer and Chen. Figure 6 was adapted from [178], M. Amer; R. K. Chen, "H...
-
![]()
Figure 7: The physical appearance of 20.06% GAN + 5% HA + 1% FS under (A) digital microscope and (B) scanning...
-
![]()
Figure 8: Individual steps in the production and use of microneedles containing nanoparticles developed by Wu...
-
![]()
Figure 9: The hybrid detachable microneedle developed by Lee et al. Figure 9 was adapted from [183], Acta Biomaterialia, v...
-
![]()
Figure 10: Cryo-sectioned optical image of a MN tip (stained with rhodamine B) embedded in the sclera by Lee e...
-
![]()
Figure 11: The photography and the principle of operation of patches developed by Than et al. Figure 11 was reproduced ...
-
