A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR)

Darinka Dzubiel, Heiko Ihmels, Mohamed M. A. Mahmoud and Laura Thomas
Beilstein J. Org. Chem. 2014, 10, 2963–2974. https://doi.org/10.3762/bjoc.10.314

Supporting Information

Figures of fluorimetric DNA denaturation experiments, photometric titration of a2 ILPR-DNA into ligands 16, photometric and fluorimetric titration of 22AG into ligands 1be, plots of the CD intensity change of a2 ILPR-DNA in presence of ligands 16 and CD spectra of 22AG in presence of ligands 1d, 1e and 6 are provided.

Supporting Information File 1: Additional experimental data.
Format: PDF Size: 1.5 MB Download

Cite the Following Article

A comparative study of the interactions of cationic hetarenes with quadruplex-DNA forming oligonucleotide sequences of the insulin-linked polymorphic region (ILPR)
Darinka Dzubiel, Heiko Ihmels, Mohamed M. A. Mahmoud and Laura Thomas
Beilstein J. Org. Chem. 2014, 10, 2963–2974. https://doi.org/10.3762/bjoc.10.314

How to Cite

Dzubiel, D.; Ihmels, H.; Mahmoud, M. M. A.; Thomas, L. Beilstein J. Org. Chem. 2014, 10, 2963–2974. doi:10.3762/bjoc.10.314

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Guneri, D.; Waller, Z. A. E. Utility of intercalator displacement assays for screening of ligands for i-motif DNA structures. Methods in enzymology 2024, 695, 221–232. doi:10.1016/bs.mie.2023.12.004
  • Wickhorst, P. J.; Ihmels, H.; Paululat, T. Studies on the Interactions of 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium and Insulin with the Quadruplex-Forming Oligonucleotide Sequence a2 from the Insulin-Linked Polymorphic Region. Molecules (Basel, Switzerland) 2021, 26, 6595. doi:10.3390/molecules26216595
  • Wickhorst, P. J.; Druzhinin, S. I.; Ihmels, H.; Müller, M.; Sardo, M. S.; Schönherr, H.; Viola, G. A Dimethylaminophenyl-Substituted Naphtho[1,2-b]quinolizinium as a Multicolor NIR Probe for the Fluorimetric Detection of Intracellular Nucleic Acids and Proteins. ChemPhotoChem 2021, 5, 1079–1088. doi:10.1002/cptc.202100148
  • Wickhorst, P. J.; Ihmels, H. Berberrubine Phosphate: A Selective Fluorescent Probe for Quadruplex DNA. Molecules (Basel, Switzerland) 2021, 26, 2566. doi:10.3390/molecules26092566
  • Becher, J.; Berdnikova, D. V.; Ihmels, H.; Stremmel, C. Synthesis and investigation of quadruplex-DNA-binding, 9-O-substituted berberine derivatives. Beilstein journal of organic chemistry 2020, 16, 2795–2806. doi:10.3762/bjoc.16.230
  • Ihmels, H.; Karbasiyoun, M.; Löhl, K.; Stremmel, C. Structural flexibility versus rigidity of the aromatic unit of DNA ligands: binding of aza- and azoniastilbene derivatives to duplex and quadruplex DNA. Organic & biomolecular chemistry 2019, 17, 6404–6413. doi:10.1039/c9ob00809h
  • Ihmels, H.; Jiang, S.; Mahmoud, M. M.; Schönherr, H.; Wesner, D.; Zamrik, I. Fluorimetric Detection of G-Quadruplex DNA in Solution and Adsorbed on Surfaces with a Selective Trinuclear Cyanine Dye. Langmuir : the ACS journal of surfaces and colloids 2018, 34, 11866–11877. doi:10.1021/acs.langmuir.8b02382
  • Ihmels, H.; Mahmoud, M. M.; Patrick, B. O. Optical differentiation between quadruplex DNA and duplex DNA with a [2.2.2]heptamethinecyanine dye. Journal of Physical Organic Chemistry 2017, 30. doi:10.1002/poc.3736
  • Nair, M. S.; D'Mello, S.; Pant, R.; Poluri, K. M. Binding of resveratrol to the minor groove of DNA sequences with AATT and TTAA segments induces differential stability. Journal of photochemistry and photobiology. B, Biology 2017, 170, 217–224. doi:10.1016/j.jphotobiol.2017.04.016
  • Pithan, P. M.; Decker, D.; Druzhinin, S. I.; Ihmels, H.; Schönherr, H.; Voß, Y. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes. RSC advances 2017, 7, 10660–10667. doi:10.1039/c6ra27684a
  • Padmapriya, K.; Barthwal, R. Binding of the alkaloid coralyne to parallel G-quadruplex DNA [d(TTGGGGT)]4 studied by multi-spectroscopic techniques. Biophysical chemistry 2016, 219, 49–58. doi:10.1016/j.bpc.2016.09.006
  • Hahn, L.; Buurma, N. J.; Gade, L. H. A water-soluble tetraazaperopyrene dye as strong G-quadruplex DNA binder. Chemistry (Weinheim an der Bergstrasse, Germany) 2016, 22, 6314–6322. doi:10.1002/chem.201504934
  • Karg, B.; Funke, A.; Ficht, A.; Sievers-Engler, A.; Lämmerhofer, M.; Weisz, K. Molecular Recognition and Visual Detection of G-Quadruplexes by a Dicarbocyanine Dye. Chemistry (Weinheim an der Bergstrasse, Germany) 2015, 21, 13802–13811. doi:10.1002/chem.201502118
Other Beilstein-Institut Open Science Activities