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- Published 26 Oct 2020
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Figure 1: Heteroacenes: tetrathienoacene (TTA), S,N-heteroacenes SN4, SN4', and SN4''.
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Scheme 1: Synthesis of fused S,N-heterotetracene SN4 9 starting from thieno[3,2-b]thiophene (1).
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Scheme 2: Synthesis of parent H-SN4 13 via the azide route.
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Scheme 3: Synthesis of tetracyclic H-SN4 13 via the Cadogan route.
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Scheme 4: Synthesis of tetracyclic indole derivative 19 via the Cadogan route.
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Scheme 5: Synthesis of hexacyclic heteroacene SN4' 22 via the Cadogan route.
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Scheme 6: Synthesis of heterotetracene SN4'' 33 via the azide and Buchwald–Hartwig amination route.
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Figure 2: UV–vis absorption spectra of TTA, Hex-SN4 9, Pr-SN4'' 33 and fluorescence spectrum of 33 in THF at ...
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Figure 3: Energy diagram of the frontier molecular orbitals of heterotetracenes TTA, 9, 13, 19, 22, and 33, a...
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- Published 23 Oct 2020
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Scheme 1: Reactivity of tetrafluoropropanes HFO-1234yf (1) (top) and HFO-1234ze (4a) (bottom) in the presence...
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Scheme 2: Reactivity of 10a in the presence of ACF as the catalyst in C6D12 (top) or C6D6 (bottom) as solvent...
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Scheme 3: Proposed catalytic cycle of the transformation of 10a in C6D12 and C6D6 in the presence of ACF as t...
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Scheme 4: Reactivity of 10a in the presence of ACF as the catalyst and HSiEt3 as a hydrogen source in C6D12 (...
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Scheme 5: Proposed catalytic cycle for sylilium-mediated hydrodefluorinations and dehydrofluorinations from 1...
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Scheme 6: Reactivity of 13 in the presence of ACF as the catalyst, with (top) or without (bottom) HSiEt3 as a...
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Scheme 7: Independent reactions starting from 5, 6, or 14 in the presence of ACF as the catalyst.
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Scheme 8: Proposed reaction pathways starting from 10a in the presence of ACF and silane.
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Scheme 9: Reactivity of 10c in the presence of ACF as the catalyst and 0.5 equivalents of HSiEt3 as a hydroge...
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Scheme 10: Proposed catalytic cycles for the transformation of 10c in C6D12 and in the presence of 0.5 equival...
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Scheme 11: Reactivity of 10c in the presence of ACF as the catalyst and HSiEt3 as a hydrogen source in C6D12 (...
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Scheme 12: Proposed reaction pathways starting from 10c in the presence of ACF and silane.
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Scheme 13: Reactivity of 10b in the presence of ACF as the catalyst and HSiEt3 as a hydrogen source in C6D12 (...
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Scheme 14: Proposed reaction pathway starting from 10b in the presence of ACF and silane.
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- Published 22 Oct 2020
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Scheme 1: General scheme of the suggested synthesis of nucleosides employing the enzymatic phosphorolysis of ...
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Figure 1: Phosphorolysis (5.0 mM K-phosphate buffer, pH 7.0; 23 °C) of Ara-U and thymidine (Thd) catalyzed by...
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Scheme 2: Transarabinosylation of O6-methylguanine (OMG) employing Ara-U as a donor of the Ara-1Pi (1:1.5 mol...
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Figure 2: Optimized conditions of phosphorolysis of Ara-U: 0.20 mmol of Ara-U in distilled water (30 mL) cont...
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Scheme 3: Synthesis of nelarabine with intermediate preparation of crude Ara-1Pi.
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Scheme 4: Synthesis of kinetin riboside with intermediate preparation of crude Rib-1Pi.
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- Published 22 Oct 2020
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Scheme 1: The mechanically assisted synthesis of mono- and poly-β-CD mesitylene sulfonate (β-CDMts).
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Figure 1: SEM images of β-CD particles a) before grinding and ground for b) 5 min, c) 10 min, d) 29 min, e) 8...
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Figure 2: Granulometric composition of β-CD particles against time after grinding at 30 Hz.
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Figure 3: XRD patterns of β-CD powders obtained after different grinding times.
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Figure 4: Compared conversions of β-CD in the synthesis of β-CDMts.
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Figure 5: Variation of the mono/poly-substituted β-CDMts ratio with time. Reactions were done using untreated...
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Figure 6: Compared conversions of β-CD in the synthesis of β-CDMts in the presence of KOH (stoichiometric pro...
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Figure 7: Variation of the mono/poly-substituted β-CDMts ratio with time in the presence of KOH (stoichiometr...
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- Published 21 Oct 2020
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Figure 1: “Record player” approach for molecular spin switching. a) General principle b) Variation of the sub...
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Scheme 1: Synthesis of the nitroso compounds 3 and 6 using the two different methods described by Wegner et a...
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Scheme 2: Synthesis of azopyridines 11, 14, 16 and 18 by nucleophilic aromatic substitution.
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Scheme 3: Synthesis of 3-(3-bromophenylazo)-4-cyanopyridine (20), which was hydrolyzed to yield 3-(3-bromophe...
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Scheme 4: Modular approach for the C–C connection of the Ni(II)-porphyrin 22 and the different 4-substituted ...
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Scheme 5: Cleavage of 1f to yield disulfide 1g [34].
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Figure 2: Hammett plot of the investigated pyridine substituents [36].
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Figure 3: UV–vis spectra of 1e (top), 1h (left) and 1j (right) in acetone water (1:9) (solid line) and after ...
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- Published 20 Oct 2020
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Figure 1: Structures of the compounds used in this study: a) crown-8 analogs; b) crown-7 analogs; c) secondar...
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Scheme 1: Schematic representation of synthetic routes towards TTFC7, exTTFC7, NDIC7, and NDIC8.
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Figure 2: Solid-state structures of a) exTTFC7 (CH3CN molecule omitted for clarity), b) NDIC7 (CH3CN molecule...
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Figure 3: a) Synthesis of the [2]rotaxane NDIRot. b) Stacked 1H NMR spectra (700 MHz, CDCl3, 298 K) of NDIC8 ...
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Figure 4: UV–vis–NIR spectra obtained by spectroelectrochemical measurements (0.1 M n-Bu4PF6, CH2Cl2/CH3CN 1:...
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- Published 16 Oct 2020
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Scheme 1: Proposed outcome of the halofluorination of (rac)-1. Only the main conformers of (rac)-1 and (rac)-...
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Scheme 2: Halofluorination reactions of the trans-diester (rac)-1.
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Scheme 3: Probable outcomes of the halofluorination of 4. Both conformers of the compounds 4, (rac)-T2a,b, an...
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Scheme 4: Halofluorination reactions of the cis-diester 4. Important NOESY interactions are indicated by two-...
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Scheme 5: Halofluorination reactions of the cis-tetrahydrophthalic imide derivative 7.
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Scheme 6: Synthesis and halofluorination of the trans-imide (rac)-10.
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Figure 1: Crystal structure of (rac)-11b.
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Scheme 7: Synthesis of the cyclic carbamide (rac)-13.
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Scheme 8: Halofluorination reactions of the γ-lactam (rac)-14. Relevant NOESY interactions are indicated by t...
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Figure 2: Crystal structure of the product (rac)-15a.
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Figure 3: Crystal structure of the product (rac)-15b.
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Scheme 9: Reactions of the diester 16 with NBS or NIS in the presence or absence of Deoxo-Fluor®.
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Scheme 10: Formation of the halolactons (rac)-17a,b. The initial attack of the halogen cation occurs at the st...
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Scheme 11: Unsuccessful halofluorination of the bicyclic diester 18.
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Scheme 12: Halofluorination reactions of the rigid tricyclic imine 19. The relevant NOESY interactions are mar...
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Scheme 13: Mechanism of the halofluorination reactions of the substrate 19. X = Br (compounds a), I (compounds...
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Scheme 14: Synthesis and halofluorination of the imide 24.
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Scheme 15: Cyclizations of halofluorinated diesters with potassium tert-butoxide. Relevant NOESY interactions ...
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Scheme 16: Mechanism of the reaction of the cyclopropanation of the compounds (rac)-2a,b and (rac)-5a with t-B...
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Scheme 17: Presumed mechanism of the reaction of the compound (rac)-6b with t-BuOK.
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Scheme 18: Cyclizations of halofluorinated tetrahydrophthalimides with DBU. Relevant NOESY interactions are ma...
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Scheme 19: Mechanism for the formation of (rac)-28 from (rac)-11a,b. Although the formation of the compound (r...
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Scheme 20: Fluoroselenations of the cyclohexenedicarboxylates (rac)-1 and 4.
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Scheme 21: PhSe+-induced lactonization of the diester 16. Relevant NOESY interactions are marked with two-head...
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Scheme 22: Oxidation of the fluoroselenide (rac)-30 under acidic and basic conditions.
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Scheme 23: Oxidation of the fluoroselenide mixture (rac)-31 under acidic and basic conditions.
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- Published 14 Oct 2020
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Figure 1: Selected TBTQ derivatives 1–5 that bind fullerenes in host–guest complexes.
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Scheme 1: Synthetic route to TBTQ-(OG)6.
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Figure 2: Fluorescence spectra of TBTQ-(OG)6 (5.0 × 10−6 M) with varying concentrations of (a) C60 and (b) C70...
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Figure 3: Absorption spectra of (a) TBTQ-(OG)6
![[Graphic 2]](/bjoc/content/inline/1860-5397-16-207-i3.svg?max-width=637&scale=1.18182)
C60 [TBTQ-(OG)6: 50 μM; C60: 50 μM] and (b) TBTQ-(OG)6 C70 [...
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Figure 4: Absorption spectra of (a) TBTQ-(OG)6
C60 [TBTQ-(OG)6: 50 μM; C60: 50 μM] and (b) TBTQ-(OG)6 C70 [...
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Figure 5: Raman spectra of TBTQ-G6, C60 and TBTQ-G6
C60. Sample solutions of TBTQ-(OG)6 (50 μM) and TBTQ-(OG)...
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Figure 6: Molecular model of the complex TBTQ-(OG)6
C60 in water, as generated by DFT calculations. (a) Side...
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Figure 7: SEM images of (a) C60; (b) TBTQ-(OG)6; (c) and (d) TBTQ-(OG)6
C60 (C60: 1.4 mM; TBTQ-(OG)6: 1.4 mM...
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- Published 13 Oct 2020
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Figure 1: A representation of mucin glycopeptide bound to AR20.5 antibody. Chain A is represented as a molecu...
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Figure 2: A comparison of root mean analyses for the antigen and Tn-antigen in solution (unbound) and in anti...
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Figure 3: End-to-end time series and histogram for the antigen and Tn-antigen in solution (A, B) and the anti...
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Figure 4: A comparison of Ramachandran analyses for two key amino acids, Asp3 and Thr4. The first row (A–D) i...
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Figure 5: Distribution of clusters, found using TTClust, for the antigen and Tn-antigen in solution (A, B) an...
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Scheme 1: Isomerization of 3а–с to diamantane (1). Reaction conditions: (a) CoBr2·2PPh3–BF3·OEt2, 110 °C, 12 ...
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Scheme 2: Isomerization of binor-S (2) to diamantane (1).
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Scheme 3: Selective synthesis of tetrahydrobinor-S (3c) from binor-S (2).
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Scheme 4: Isomerization of binor-S (2) to hydrocarbons 4а and b.
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