Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

Wolfgang Hüttel, Jonathan B. Spencer and Peter F. Leadlay
Beilstein J. Org. Chem. 2014, 10, 361–368. https://doi.org/10.3762/bjoc.10.34

Cite the Following Article

Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding
Wolfgang Hüttel, Jonathan B. Spencer and Peter F. Leadlay
Beilstein J. Org. Chem. 2014, 10, 361–368. https://doi.org/10.3762/bjoc.10.34

How to Cite

Hüttel, W.; Spencer, J. B.; Leadlay, P. F. Beilstein J. Org. Chem. 2014, 10, 361–368. doi:10.3762/bjoc.10.34

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Wang, Q.; Liu, N.; Deng, Y.; Guan, Y.; Xiao, H.; Nitka, T. A.; Yang, H.; Yadav, A.; Vukovic, L.; Mathews, I. I.; Chen, X.; Kim, C.-Y. Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis. Nature communications 2023, 14, 6273. doi:10.1038/s41467-023-41889-0
  • Sedjoah, R.-C. A.-A.; Sun, S.; Abdalmegeed, D.; Shao, Y.; Wu, G.; Wu, Z.; Wang, M.; Zhou, J.; Zheng, J.; Xin, Z. Overexpression of PPtase in Streptomyces sp. NAUS: Increasing biocontrol potential against postharvest tomato fruit decay and isolation of a novel antifungal compound. Postharvest Biology and Technology 2023, 204, 112462. doi:10.1016/j.postharvbio.2023.112462
  • Heinrich, S.; Grote, M.; Sievers, S.; Kushnir, S.; Schulz, F. Polyether Cyclization Cascade Alterations in Response to Monensin Polyketide Synthase Mutations. Chembiochem : a European journal of chemical biology 2021, 23, e202100584. doi:10.1002/cbic.202100584
  • Cho, E.-S.; Krishnan, P.; Loh, H.-S.; Daly, J. M.; Leong, C.-O.; Mai, C.-W.; Low, Y.-Y.; Yong, K.-T.; Lim, K.-H. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus. Phytochemistry 2021, 193, 112988. doi:10.1016/j.phytochem.2021.112988
  • Bondarev, N. V. Computer Analysis of Stability of Cation Complexes with Ionophore Antibiotics. Russian Journal of General Chemistry 2020, 90, 1474–1482. doi:10.1134/s1070363220080149
  • Erwin, G. S.; Heikkinen, J.; Halimaa, P.; Haber, C. L. Streptomyces lasalocidi sp. nov. (formerly 'Streptomyces lasaliensis'), an actinomycete isolated from soil which produces the polyether antibiotic lasalocid. International journal of systematic and evolutionary microbiology 2020, 70, 3076–3083. doi:10.1099/ijsem.0.004135
  • Lin, C.-Y.; Zhang, Y.; Wu, J.; Xie, R.-H.; Qiao, J.; Zhao, G.-R. Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis. Microorganisms 2020, 8, 271. doi:10.3390/microorganisms8020271
  • Liu, R.; Fang, F.; An, Z.; Huang, R.; Wang, Y.; Sun, X.; Fu, S.; Fu, A.; Deng, Z.; Liu, T. Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007. Journal of industrial microbiology & biotechnology 2020, 47, 275–285. doi:10.1007/s10295-019-02256-5
  • Robertsen, H. L.; Musiol-Kroll, E. M. Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs. Antibiotics (Basel, Switzerland) 2019, 8, 157. doi:10.3390/antibiotics8040157
  • Koutsoumanis, K.; Allende, A.; Alvarez-Ordóñez, A.; Bolton, D.; Bover-Cid, S.; Chemaly, M.; Davies, R.; De Cesare, A.; Hilbert, F.; Lindqvist, R.; Nauta, M.; Peixe, L.; Ru, G.; Simmons, M.; Skandamis, P. N.; Suffredini, E.; Cocconcelli, P. S.; Escámez, P. S. F.; Maradona, M. P.; Querol, A.; Sijtsma, L.; Suárez, J. E.; Sundh, I.; Vlak, J. M.; Barizzone, F.; Hempen, M.; Herman, L. Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 13: suitability of taxonomic units notified to EFSA until September 2020. EFSA journal. European Food Safety Authority 2019, 17, 6377. doi:10.2903/j.efsa.2019.5753
  • Grote, M.; Schulz, F. Exploring the Promiscuous Enzymatic Activation of Unnatural Polyketide Extender Units in Vitro and in Vivo for Monensin Biosynthesis. Chembiochem : a European journal of chemical biology 2019, 20, 1183–1189. doi:10.1002/cbic.201800734
  • de Almeida, R. T. R.; do Prado, R. M.; Porto, C.; dos Santos, G. T.; Huws, S.; Pilau, E. J. Exploring the rumen fluid metabolome using liquid chromatography-high-resolution mass spectrometry and Molecular Networking. Scientific reports 2018, 8, 17971. doi:10.1038/s41598-018-36196-4
  • Rudolf, J. D.; Chang, C.-Y.; Ma, M.; Shen, B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural product reports 2017, 34, 1141–1172. doi:10.1039/c7np00034k
  • Ricci, A.; Allende, A.; Bolton, D.; Chemaly, M.; Davies, R.; Girones, R.; Koutsoumanis, K.; Lindqvist, R.; Nørrung, B.; Robertson, L.; Ru, G.; Fernandez Escamez, P. S.; Sanaa, M.; Simmons, M.; Skandamis, P.; Snary, E.; Speybroeck, N.; Ter Kuile, B.; Threlfall, J.; Wahlström, H.; Cocconcelli, P. S.; Peixe, L.; Maradona, M. P.; Querol, A.; Suarez, J. E.; Sundh, I.; Vlak, J.; Correia, S.; Herman, L. Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 6: suitability of taxonomic units notified to EFSA until March 2017. EFSA journal. European Food Safety Authority 2017, 15, e04884. doi:10.2903/j.efsa.2017.4884
  • Tang, Z.-K.; Li, X.-M.; Pang, A.-P.; Lin, C.-Y.; Zhang, Y.; Zhang, J.; Qiao, J.; Zhao, G.-R. Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis. Applied microbiology and biotechnology 2017, 101, 6083–6097. doi:10.1007/s00253-017-8353-y
  • Gross, L. J.; Stark, C. B. W. Regioselective dehydration of α-hydroxymethyl tetrahydrofurans using Burgess' reagent under microwave irradiation. Organic & biomolecular chemistry 2017, 15, 4282–4285. doi:10.1039/c7ob00607a
  • Zhang, Y.; Lin, C.-Y.; Li, X.-M.; Tang, Z.-K.; Qiao, J.; Zhao, G.-R. DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis. Journal of industrial microbiology & biotechnology 2016, 43, 1681–1692. doi:10.1007/s10295-016-1845-4
  • AlMatar, M.; Eldeeb, M. A.; Makky, E. A.; Köksal, F.; Var, I.; Kayar, B. Are There Any Other Compounds Isolated From Dermacoccus spp at All. Current microbiology 2016, 74, 132–144. doi:10.1007/s00284-016-1152-3
  • Aoki, K.; Murayama, K.; Hu, N. H. Solid State Structures of Alkali Metal Ion Complexes Formed by Low-Molecular-Weight Ligands of Biological Relevance. Metal ions in life sciences 2016, 16, 27–101. doi:10.1007/978-3-319-21756-7_3
  • Matilla, M. A.; Leeper, F. J.; Salmond, G. P. C. Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq. Environmental microbiology 2015, 17, 2993–3008. doi:10.1111/1462-2920.12839

Patents

  • ZHANG XIAOJUN; WANG SHOUKUI; TANG SHOUZHONG; CHEN JINGJING; GENG YINGMING; DING XINREN. Preparation method of monensin sodium, monensin sodium and products of monensin sodium. CN 108929331 A, Dec 4, 2018.
Other Beilstein-Institut Open Science Activities