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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Marcus Baumann and Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 1194–1219. https://doi.org/10.3762/bjoc.11.134

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Marcus Baumann and Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 1194–1219. https://doi.org/10.3762/bjoc.11.134

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Baumann, M.; Baxendale, I. R. Beilstein J. Org. Chem. 2015, 11, 1194–1219. doi:10.3762/bjoc.11.134

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TY  - JOUR
A1  - Baumann, Marcus
A1  - Baxendale, Ian R.
T1  - The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry
JF  - Beilstein Journal of Organic Chemistry
PY  - 2015///
VL  - 11
SP  - 1194
EP  - 1219
SN  - 1860-5397
DO  - 10.3762/bjoc.11.134
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.11.134
KW  - continuous processing
KW  - flow synthesis
KW  - in-line analysis
KW  - manufacture
KW  - pharmaceuticals
KW  - scalability
N2  - The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.
ER  -

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