The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Scholarly Works

• Barozzi, M.; Fernández García, J.; Berzosa Rodríguez, X.; Sempere, J.; Tomaso, S. D.; Copelli, S. A simple AI-driven process intensification protocol for active pharmaceutical ingredients synthesis. Chemical Engineering Journal Advances 2025, 24, 100905. doi:10.1016/j.ceja.2025.100905
• Jaklova, N.; Stavarek, P.; Vychodilova, H.; Malikova, S.; Kluson, P.; Holas, T. Phase transfer catalysis of N-alkylation of a lysergic acid derivative in microfluidic systems. Chemical Engineering Journal 2025, 523, 167999. doi:10.1016/j.cej.2025.167999
• Patil, S. R.; Dighule, V. R.; Bhagat, K. K.; Reshamwala, S.; Arote, N. D. Active Pharmaceutical Ingredients Using Biocatalyst for Circular Bioeconomy. Sustainable Waste Management Towards Circular Bioeconomy; Springer Nature Singapore, 2025; pp 317–350. doi:10.1007/978-981-95-2227-9_13
• Mirchi, A.; Kazemeini, M.; Hosseinpour, V. Continuous-flow synthesis of Clopidogrel through different chip-microreactors and comparing of performances with that of a batch approach: A CFD simulation and an optimization study. Chemical Engineering and Processing - Process Intensification 2025, 216, 110389. doi:10.1016/j.cep.2025.110389
• Ren, Y.; Yang, W.; Li, W.; Lv, J.; Luo, Z.; Zhang, Y.; Yuan, Z. Continuous flow synthesis technology for ibuprofen: progress and challenges. SCIENTIA SINICA Chimica 2025. doi:10.1360/ssc-2025-0218
• Susarla, N. L. R.; Velaga, D. J. R.; Sardar, M. Y.; Ghosh, A.; Gorle, R. K.; Jawlekar, S.; Budhdev, R. R.; Ramakrishnan, S. Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control. Organic Process Research & Development 2025, 29, 1662–1676. doi:10.1021/acs.oprd.4c00478
• Stefanache, A.; Marcinschi, A.; Marin, G.-A.; Mitran, A.-M.; Lungu, I. I.; Miftode, A. M.; Crivoi, F.; Lacatusu, D.; Baican, M.; Cioanca, O.; Hancianu, M. Green Chemistry Approaches in Pharmaceutical Synthesis: Sustainable Methods for Drug Development. AppliedChem 2025, 5, 13. doi:10.3390/appliedchem5020013
• Zielke, M.; Aellig, C.; Roberge, D. M.; Hone, C. A.; Kappe, C. O. Two-step continuous flow aerobic oxidation of cannabidiol to cannabinoquinone derivatives. Green Chemistry 2025, 27, 6787–6795. doi:10.1039/d5gc01304f
• Kashinath, K. P.; Sanjay, L. R.; Ashokbhai, M. K.; Roy, S.; Sardar, M. S.; Kaity, S. Continuous manufacturing based paradigm shift in pharmaceuticals production and current regulatory framework. Chemical Engineering Research and Design 2025, 215, 1–22. doi:10.1016/j.cherd.2025.01.003
• Bratsun, D.; Mizev, A.; Siraev, R.; Krasnyakova, E. Control of mixing in a continuous-flow microreactor with an integrated bubble. Journal of Flow Chemistry 2025, 15, 59–66. doi:10.1007/s41981-025-00343-6
• Wankhede, P.; Kulkarni, A. A. Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction. Organic Process Research & Development 2025, 29, 450–459. doi:10.1021/acs.oprd.4c00447
• Luo, G.; Wang, K.; Deng, J. Overview of microchemical technology. Microchemical Engineering and Technology; Elsevier, 2025; pp 1–22. doi:10.1016/b978-0-443-18522-9.00005-0
• Ivanova, M.; Poisson, T.; Jubault, P.; Chausset-Boissarie, L.; Legros, J. Organic Synthesis in Flow. Comprehensive Organic Synthesis; Elsevier, 2025; pp 53–86. doi:10.1016/b978-0-323-96025-0.00046-6
• Barozzi, M.; García, J. F.; Rodríguez, X. B.; Sempere, J.; Di Tomaso, S.; Copelli, S. A simple AI-Driven Process Intensification Protocol for Active Pharmaceutical Ingredients Synthesis. Elsevier BV 2025. doi:10.2139/ssrn.5412749
• Bucciol, F.; Cintas, P.; Cravotto, G. Sonochemical Activation in Flow Systems. Encyclopedia of Green Chemistry; Elsevier, 2025; pp 315–324. doi:10.1016/b978-0-443-15742-4.00142-3
• Kelly, C. B.; Compton, J. S.; Bryan, M. C.; Lambert, K. M.; Phelan, J. P. Going Green: Sustainable Alternatives in Organic Synthesis. Comprehensive Organic Synthesis; Elsevier, 2025; pp 112–175. doi:10.1016/b978-0-323-96025-0.00100-9
• Wong, M. J.; Freiberg, K. M.; Reynafarje Jones, T.; Dismuke Rodriguez, K. B.; Wood, A. B.; Lipshutz, B. H. SNAr Reactions Using Continuous Plug Flow...in Aqueous Biphasic Media. ACS Sustainable Chemistry & Engineering 2024, 12, 18725–18734. doi:10.1021/acssuschemeng.4c08612
• Koeberg, B. L.; Sagandira, M. B.; Sagandira, C. R.; Watts, P. Paradigm shift in medicinal products synthesis: Continuous flow technology. Tetrahedron 2024, 168, 134333. doi:10.1016/j.tet.2024.134333
• Panda, S. S. Advancements in ecotoxicological assessment of anticancer agents: Bridging sustainability and innovation in chemical testing. Green Analytical Chemistry 2024, 11, 100162. doi:10.1016/j.greeac.2024.100162
• Ahmad, S.; Jaiswal, R.; Yadav, R.; Verma, S. Recent advances in green chemistry approaches for pharmaceutical synthesis. Sustainable Chemistry One World 2024, 4, 100029. doi:10.1016/j.scowo.2024.100029

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