Synthesis of highly functionalized 2,2'-bipyridines by cyclocondensation of β-ketoenamides – scope and limitations

Scholarly Works

• Intamalee, P.; Maneewong, J.; Saehlim, N.; Silalai, P.; Chairoungdua, A.; Saeeng, R. Synthesis of Caerulomycins E and A Analogs for Studying Cytotoxic Activity. ChemMedChem 2025, e202500594. doi:10.1002/cmdc.202500594
• Parui, N.; Paul, P.; Ahashan, S. J.; Dash, J. Regioselective and Chemodivergent Synthesis of 1,3-Indandione-Fused Spirocyclopentenes and Spiropyrrolidines. The Journal of organic chemistry 2025, 90, 8886–8902. doi:10.1021/acs.joc.5c00490
• Degli Innocenti, M.; Schreiner, T.; Breinbauer, R. Recent Advances in Pd‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reactions with Triflates or Nonaflates. Advanced Synthesis & Catalysis 2023, 365, 4086–4120. doi:10.1002/adsc.202301124
• Kurzawa, T.; Zimmer, R.; Würthwein, E.-U.; Reissig, H.-U. The Boekelheide Rearrangement of Pyrimidine N-oxides as a Case Study of Closed or Open Shell Reactions - Experimental and Computational Evidence for the Participation of Radical Intermediates. Chemistry (Weinheim an der Bergstrasse, Germany) 2023, 29, e202204015. doi:10.1002/chem.202204015
• Subramanian, L. R.; García Martínez, A.; Hanack, M.; Singh, S. K.; Kosarev, S. A.; Collier, S. J.; Lu, H. doi:10.1002/047084289x.rn061.pub3
• Hapke, M. Comprehensive Heterocyclic Chemistry IV - Pyridines and Benzo Derivatives: Synthesis. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; pp 150–216. doi:10.1016/b978-0-12-818655-8.00108-6
• Brennecke, B.; Micó, A. C.; Selter, L.; Accorsi, M.; Zimmer, R.; Reissig, H.-U. A Proline and 4-Hydroxyproline Based Approach to Enantiopure Pyrrolidin-2-yl-Substituted Pyridine and Pyrimidine Derivatives. European Journal of Organic Chemistry 2021, 2021, 4750–4761. doi:10.1002/ejoc.202100887
• Arevalo, R.; López, R.; Falvello, L. R.; Riera, L.; Pérez, J. Building C(sp3 ) Molecular Complexity on 2,2'-Bipyridine and 1,10-Phenanthroline in Rhenium Tricarbonyl Complexes. Chemistry (Weinheim an der Bergstrasse, Germany) 2020, 27, 379–389. doi:10.1002/chem.202003814
• Kleoff, M.; Suhr, S.; Sarkar, B.; Zimmer, R.; Reissig, H.-U.; Marin-Luna, M.; Zipse, H. Efficient Syntheses of New Super Lewis Basic Tris(dialkylamino)-Substituted Terpyridines and Comparison of Their Methyl Cation Affinities. Chemistry (Weinheim an der Bergstrasse, Germany) 2019, 25, 7526–7533. doi:10.1002/chem.201900450
• Ji, Y.; Lee, H. J.; Kim, M.; Nam, G.; Lee, S. J. C.; Cho, J.; Park, C.-M.; Lim, M. H. Strategic Design of 2,2′-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation. Inorganic chemistry 2017, 56, 6695–6705. doi:10.1021/acs.inorgchem.7b00782
• Hirai, S.; Horikawa, Y.; Asahara, H.; Nishiwaki, N. Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones. Chemical communications (Cambridge, England) 2017, 53, 2390–2393. doi:10.1039/c7cc00051k
• De Rache, A.; Gueddouda, N. M.; Bourdoncle, A.; Hommes, P.; Reissig, H.-U.; Mergny, J.-L. A Flexible Terpyridine Derivative Interacts Specifically with G‐Quadruplexes. Chemistry (Weinheim an der Bergstrasse, Germany) 2016, 22, 12651–12654. doi:10.1002/chem.201603021
• Hommes, P.; Reissig, H.-U. Synthesis of Highly Functionalized 2,2′-Bipyridines by Cyclocondensation of β-Ketoenamides - Scope and Limitations. ChemInform 2016, 47. doi:10.1002/chin.201633146
• Hommes, P.; Reissig, H.-U. Synthesis and Photophysical Properties of Substituted 2,2′:6′,2′′‐Terpyridine Derivatives and Analogous Compounds with a Central Thiophene Ring. Asian Journal of Organic Chemistry 2016, 5, 1033–1040. doi:10.1002/ajoc.201600215

Explore citations to this article at