Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction

Scholarly Works

• Bao, Y.; Han, X.; Zhang, X.; Li, T.; Li, T.; Wang, Z.; Jin, Y. Photo-induced synthesis, stereochemistry and antitumor activity of natural cyclopeptide Hikiamide B analogs. Journal of Molecular Structure 2023, 1290, 135894. doi:10.1016/j.molstruc.2023.135894
• Bhatia, N.; Khator, R.; Kulkarni, S.; Singh, Y.; Kumar, P.; Thareja, S. Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer. Current medicinal chemistry 2023, 30, 3668–3701. doi:10.2174/0929867330666221114103924
• Karcev, D. D.; Efremova, M. M.; Molchanov, A. P.; Rostovskii, N. V.; Kryukova, M. A.; Bunev, A. S.; Khochenkov, D. A. Selective and Reversible 1,3-Dipolar Cycloaddition of 2-(2-Oxoindoline-3-ylidene)acetates with Nitrones in the Synthesis of Functionalized Spiroisoxazolidines. International journal of molecular sciences 2022, 23, 12639. doi:10.3390/ijms232012639
• Assunta Chiacchio, M.; Iannazzo, D.; Giofrè, S. V.; Romeo, R.; Legnani, L. Ruthenium tetroxide oxidation of N-methyl-isoxazolidine: Computational mechanistic study. Arabian Journal of Chemistry 2022, 15, 104063. doi:10.1016/j.arabjc.2022.104063
• Zhang, H.; Wu, J.; Wang, J.; Xiao, S.; Zhao, L.; Yan, R.; Wu, X.; Wang, Z.; Fan, L.; Jin, Y. Novel Isoindolinone-Based Analogs of the Natural Cyclic Peptide Fenestin A: Synthesis and Antitumor Activity. ACS medicinal chemistry letters 2022, 13, 1118–1124. doi:10.1021/acsmedchemlett.2c00149
• Xiao, S.; Wang, Z.; Zhang, H.; Zhao, L.; Chang, Q.; Zhang, X.; Yan, R.; Wu, X.; Jin, Y. Photoinduced Synthesis of Methylated Marine Cyclopeptide Galaxamide Analogs with Isoindolinone as Anticancer Agents. Marine drugs 2022, 20, 379. doi:10.3390/md20060379
• Chiacchio, M. A.; Legnani, L.; Chiacchio, U.; Iannazzo, D. doi:10.1002/9781119757153.ch16
• Cordero, F. M.; Giomi, D.; Machetti, F. 4.03 – Isoxazoles. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; Vol. 4, pp 308–434. doi:10.1016/b978-0-12-818655-8.00135-9
• Gabriele, B.; Della Ca, N.; Mancuso, R.; Veltri, L.; Ziccarelli, I. Carbon Monoxide in Organic Synthesis; Wiley, 2021; pp 235–294. doi:10.1002/9783527829354.ch8
• Efremova, M. M.; Makarova, A. A.; Novikov, A. S.; Kryukova, M. A.; Kuznetsov, M. A.; Molchanov, A. P. Regio- and stereoselective (3 + 2)-cycloaddition reactions of nitrones with cyclic allenes. Organic & biomolecular chemistry 2021, 19, 9773–9784. doi:10.1039/d1ob01584b
• Gataullin, R. R. Advances in the Synthesis of Benzo‐Fused Spiro Nitrogen Heterocycles: New Approaches and Modification of Old Strategies. Helvetica Chimica Acta 2020, 103. doi:10.1002/hlca.202000137
• Bao, Y.; Jiang, S.; Zhao, L.; Jin, Y.; Yan, R.; Wang, Z. Photoinduced synthesis and antitumor activity of a phakellistatin 18 analog with an isoindolinone fragment. New Journal of Chemistry 2020, 44, 19174–19178. doi:10.1039/d0nj03005h
• Chiacchio, M. A.; Legnani, L.; Chiacchio, U. Synthetic Approaches to Nonaromatic Nitrogen Heterocycles; Wiley, 2020; pp 161–177. doi:10.1002/9781119708841.ch7
• Liu, P.; Fu, W.; Verwilst, P.; Won, M.; Shin, J.; Cai, Z.; Tong, B.; Shi, J.; Dong, Y.; Kim, J. S. MDM2‐Associated Clusterization‐Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer. Angewandte Chemie 2020, 132, 8513–8517. doi:10.1002/ange.201916524
• Liu, P.; Fu, W.; Verwilst, P.; Won, M.; Shin, J.; Cai, Z.; Tong, B.; Shi, J.; Dong, Y.; Kim, J. S. MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer. Angewandte Chemie (International ed. in English) 2020, 59, 8435–8439. doi:10.1002/anie.201916524
• Armentano, B.; Curcio, R.; Brindisi, M.; Mancuso, R.; Rago, V.; Ziccarelli, I.; Frattaruolo, L.; Fiorillo, M.; Dolce, V.; Gabriele, B.; Cappello, A. R. 5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer. Biomedicines 2020, 8, 35. doi:10.3390/biomedicines8020035
• Gataullin, R. R.; Zileeva, Z. R.; Maksimova, M. A.; Zainullina, L. F.; Vakhitova, Y. V. Synthesis of (1′S*,2R*,3R*)‐ and (1′S*,2R*,3S*)‐N‐arylsulfonyl‐2‐(1′‐halogenethyl)‐3‐methylindolines and their selective toxicity against SH‐SY5Y cell line. Journal of Heterocyclic Chemistry 2020, 57, 1236–1248. doi:10.1002/jhet.3861
• Teterina, P. S.; Efremova, M. M.; Sirotkina, E. V.; Novikov, A. S.; Khoroshilova, O. V.; Molchanov, A. P. A highly efficient and stereoselective cycloaddition of nitrones to N-arylitaconimides. Tetrahedron Letters 2019, 60, 151063. doi:10.1016/j.tetlet.2019.151063
• Mancuso, R.; Della Ca, N.; Veltri, L.; Ziccarelli, I.; Gabriele, B. PdI2-Based Catalysis for Carbonylation Reactions: A Personal Account. Catalysts 2019, 9, 610. doi:10.3390/catal9070610
• Mancuso, R.; Ziccarelli, I.; Fini, F.; Della Ca, N.; Marino, N.; Carfagna, C.; Gabriele, B. A Regio- and Stereoselective Carbonylative Approach to Alkyl (Z)-2-[3-Oxoisobenzofuran-1-(3H)-ylidene]acetates. Advanced Synthesis & Catalysis 2018, 361, 690–695. doi:10.1002/adsc.201801308

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