Mechanochemical synthesis of small organic molecules

Scholarly Works

• Pramanik, T.; Pal, S.; Sultana, N.; Kundu, A.; Mukherjee, A.; Santra, S.; Begum, N. A.; Rath, J.; Zyryanov, G. V.; Majee, A. Mechanochemical synthesis of pyrrolo[1,2-a]indoles via consecutive C-C and C-N bond formation in the presence of an ionic liquid: antimicrobial and photophysical studies. Organic & biomolecular chemistry 2026, 24, 142–151. doi:10.1039/d5ob01489a
• Millward, F.; Zysman-Colman, E. Shaking Up Photochemistry: The Future Frontiers of Mechanophotocatalysis. ACS Central Science 2026. doi:10.1021/acscentsci.5c01770
• Hiroishi, K.; Matsumoto, H.; Kasai, H.; Nagao, M.; Nishibori, E.; Miura, Y. Solvent-less mechanochemical asymmetric reactions in a ball mill utilizing a polymer-supported Hayashi–Jørgensen catalyst: effects of the polymer backbone and flexibility on its catalytic performance. Green Chemistry 2026. doi:10.1039/d5gc05291b
• Gnanasekaran, P.; Chao, Y.-Q.; Chen, C.-Y.; Chen, Y.-T.; Peng, J.-K.; Lin, J.-C.; Lu, C.-W.; Chang, C.-H.; Chang, Y. J. Green, solvent-free synthesis of divinylbenzo[ c ][1,2,5]thiadiazole emitters via the hand-grinding Horner–Wadsworth–Emmons reaction for high-performance OLEDs. Journal of Materials Chemistry C 2026. doi:10.1039/d5tc03807c
• Xu, Q.; Cui, Q.; Wang, J. Efficient synthesis of benzo(hetero)aryl-5-yl(2-hydroxyphenyl)methanones via mechanochemical benzannulation. Chemical communications (Cambridge, England) 2025. doi:10.1039/d5cc06020f
• Hu, X.-W.; Wu, L.-T.; He, Z.-Y.; Hu, J.-T.; Fan, S.-Z.; Zhang, Z.; Xu, H. Copper-Catalyzed Domino Reaction of Arylidene Isoxazolones with 2-(Pyridin-2-yl)acetate Derivatives under Ball Milling: A Rapid and Economical Synthesis of 3-Acylindolizines. Organic letters 2025, 27, 14058–14063. doi:10.1021/acs.orglett.5c04683
• Bankar, S. R.; Jadhav, V. H. Modification of some steps in the synthesis of Ivacaftor by mechano-chemical approach. Sustainable Chemistry for Climate Action 2025, 7, 100097. doi:10.1016/j.scca.2025.100097
• Nagao, A.; Kubota, K.; Ito, H. All-step Mechanochemical Approach for the Rapid and Solventless Synthesis of Boscalid. Synthesis 2025. doi:10.1055/a-2744-6831
• de Lima, P. S.; de Almeida Cardoso, A.; Nobrega, J. A.; de Freitas e Silva, P. M.; da Silva, J. d. O.; de Oliveira Santos, M. B.; Sobral, M. V.; de Moura, R. O.; dos Santos Nascimento, I. J.; de Menezes Torres, M. d. C. Synthesis and evaluation in vitro and in silico of chalcones derivatives as potential antibacterial and anticancer. Journal of Molecular Structure 2025, 1345, 143187. doi:10.1016/j.molstruc.2025.143187
• Tomita, N.; Sajiki, H.; Ikawa, T. Synthesis of cyclic carbonates via silver-catalysed fixation of CO 2 to propargyl alcohols under mechanochemical conditions. RSC Mechanochemistry 2025, 2, 809–812. doi:10.1039/d5mr00072f
• Zhang, Q.; Li, H.; Guo, Z.; Chen, H.; Guo, F. Mechanosynthesis of Copper(II) Complexes Involving Diverse Nuclearities, Polymorphs, and Magnetic and Optical Properties. Inorganic chemistry 2025, 64, 20939–20948. doi:10.1021/acs.inorgchem.5c02919
• Lee, S.; Kim, Y.; Hong, S. W.; Bang, J.; Kim, J. H.; Park, J. H. Recycling of unsorted post-consumer polyethylene and polyethylene terephthalate via mechanochemical compatibilization for food packaging. Sustainable Materials and Technologies 2025, 45, e01562. doi:10.1016/j.susmat.2025.e01562
• Vasconcelos, A. A.; Gatti, L. C. P.; de Mescouto, V. A.; de Oliveira, A. d. N.; Melchiorre, M.; Noronha, R. C. R.; Luque, R.; Esposito, R.; Nascimento, L. A. S. d. Mechanochemistry in Waste Valorization: Advances in the Synthesis of Catalysts, Polymers, and Functional Materials. Catalysts 2025, 15, 897. doi:10.3390/catal15090897
• Al-Ithawi, W. K. A.; Al-Azawi, K. F.; Mohsen, A. M.; Al-Ghezi, B. S. M.; Sharapov, A. D.; Kopchuk, D. S.; Kovalev, I. S.; Zyryanov, G. V. Sustainable Approach to 4-Aminoantipyrine Schiff Bases Using a Single Screw Drill Reactor. Russian Journal of General Chemistry 2025, 95, 2299–2302. doi:10.1134/s1070363225602960
• Han, J.; Wzorek, A.; Ono, T.; Klika, K.; Soloshonok, V. MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING. Ukrainian Chemistry Journal 2025, 91, 35–55. doi:10.33609/2708-129x.91.7.2025.35-55
• Hinojosa, S. K.; Dogan, T.; Fabig, S.; Grätz, S.; Borchardt, L. How to Track Mechanochemical Reactions in Resonant Acoustic Mixers by in Situ Raman Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e01336. doi:10.1002/chem.202501336
• More, K. S.; Nikam, P. D.; Gadkari, Y. U. Hot Melt Extrusion Assisted Synthesis of 3-Methyl-4-arylmethyleneisoxazole-5(4H)-ones: A Continuous and Sustainable Approach. Russian Journal of General Chemistry 2025, 95, 1660–1669. doi:10.1134/s1070363225601218
• Dehelean, C. A.; Boru, C.; Macașoi, I. G.; Dumitrel, Ș.-I.; Trandafirescu, C.; Ersilia, A. Obtaining and Characterization of Nutraceuticals Based on Linoleic Acid Derivatives Obtained by Green Synthesis and Their Valorization in the Food Industry. Nutrients 2025, 17, 2416. doi:10.3390/nu17152416
• Jana, K.; Kubota, K.; Ito, H. A mechanochemical [2+2+2] cycloaddition facilitated by a cobalt(ii) catalyst and piezoelectric materials. Chemical science 2025, 16, 11468–11474. doi:10.1039/d5sc02074c
• Méndez-Gálvez, C.; Barnå, F.; Olsthoorn, B.; Estébanez Rosich, D.; Gates, P. J.; Pilarski, L. T. Solventless Catalytic C-H and C-X Functionalization without Ball Milling. The Journal of organic chemistry 2025, 90, 8846–8856. doi:10.1021/acs.joc.5c00109

Explore citations to this article at