Mechanochemical Knoevenagel condensation investigated in situ

Scholarly Works

• Za'im, S. I. N.; Dewi, R. S.; Johan, M. R.; Khaligh, N. G. Study of substrate–organocatalyst interactions in the model Knoevenagel mechanochemical condensation. Research on Chemical Intermediates 2025. doi:10.1007/s11164-025-05762-7
• Mazaraki, K.; Tsirozidou, A. E.; Kakarikas, B.; Zografos, A. L. Mechanochemical synthesis of tetramic acids and their biomimetic ring expansion to 4-hydroxy-2-pyridones. Green Chemistry 2025, 27, 10974–10979. doi:10.1039/d5gc03085d
• Hinojosa, S. K.; Dogan, T.; Fabig, S.; Grätz, S.; Borchardt, L. How to Track Mechanochemical Reactions in Resonant Acoustic Mixers by in Situ Raman Spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e01336. doi:10.1002/chem.202501336
• Xiao, Y.; Bradley, D. G.; Chan, W. X.; Hu, X.; Xiao, L.; Liu, Z.; Tan, Z. Y.; Zhao, X.; Li, C.; Sadek, M.; Ravi, V. K.; Tam, Y. H.; Wang, X.; García, F.; Sun, H.; Low, S. C.; Phua, P. B.; Sum, T. C.; Zhou, X.; Lim, Y.-F.; Hanna, J. V.; Soo, H. S. Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems. Nature communications 2025, 16, 1362. doi:10.1038/s41467-025-56571-w
• Llamosi, A.; Danylyuk, O.; Szumna, A. Facile and Versatile Mechanochemical Synthesis of Indigoid Photoswitches. ChemSusChem 2025, 18, e202402503. doi:10.1002/cssc.202402503
• Zaharani, L.; Johari, S.; Johan, M. R.; Khaligh, N. G. Synthesis, Characterization, and the Study of Thermal Behavior and Catalytic Activity of a Halogen-free Dicationic Ionic Liquid. Catalysis Letters 2024, 154, 4523–4534. doi:10.1007/s10562-024-04665-3
• Johari, S.; Johan, M. R.; Khaligh, N. G. Mechanism study and preparing (hetero)arylidene malononitriles through a greener and scalable catalytic strategy. Journal of Molecular Structure 2024, 1302, 137422. doi:10.1016/j.molstruc.2023.137422
• Wang, G.-W.; Wang, N.; Pan, H.; Shao, G.; Chen, J.-S. Mechanochemistry in organic synthesis. Introduction to Condensed Matter Chemistry; Elsevier, 2024; pp 73–103. doi:10.1016/b978-0-443-16140-7.00012-2
• Johari, S.; Johan, M. R.; Khaligh, N. G. Organocatalytic Synthesis of (Hetero)arylidene Malononitriles Using a More Sustainable, Greener, and Scalable Strategy. Current organic synthesis 2024, 21, 704–716. doi:10.2174/0115701794268766231108110816
• Scheurrell, K.; B Martins, I. C.; Murray, C.; Emmerling, F. Exploring the role of solvent polarity in mechanochemical Knoevenagel condensation: in situ investigation and isolation of reaction intermediates. Physical chemistry chemical physics : PCCP 2023, 25, 23637–23644. doi:10.1039/d3cp02883f
• Naidu, B. R.; Sruthi, T.; Mitty, R.; Venkateswarlu, K. Catalyst-free mechanochemistry as a versatile tool in synthetic chemistry: a review. Green Chemistry 2023, 25, 6120–6148. doi:10.1039/d3gc01229h
• Kumar, N.; Maiti, N.; Thomas, S. Insights into Plasmon-Induced Dimerization of Rhodanine-A Surface-Enhanced Raman Scattering Study. The journal of physical chemistry. A 2023, 127, 4429–4439. doi:10.1021/acs.jpca.3c00902
• Lopes, C.; Cartigny, Y.; Brandel, C.; Dupray, V.; Body, C.; Shemchuk, O.; Leyssens, T. A Greener Pathway to Enantiopurity: Mechanochemical Deracemization through Abrasive Grinding. Chemistry (Weinheim an der Bergstrasse, Germany) 2023, 29, e202300585. doi:10.1002/chem.202300585
• Michalchuk, A. A. L.; Emmerling, F. Time-Resolved In Situ Monitoring of Mechanochemical Reactions. Angewandte Chemie (International ed. in English) 2022, 61, e202117270. doi:10.1002/anie.202117270
• Michalchuk, A. A. L.; Emmerling, F. Zeitaufgelöste In‐Situ‐Untersuchungen von mechanochemischen Reaktionen. Angewandte Chemie 2022, 134. doi:10.1002/ange.202117270
• Leroy, C.; Métro, T.-X.; Hung, I.; Gan, Z.; Gervais, C.; Laurencin, D. From Operando Raman Mechanochemistry to "NMR Crystallography": Understanding the Structures and Interconversion of Zn-Terephthalate Networks Using Selective 17O-Labeling. Chemistry of materials : a publication of the American Chemical Society 2022, 34, 2292–2312. doi:10.1021/acs.chemmater.1c04132
• Jose, A.; Guest, D.; LeGay, R.; Tizzard, G. J.; Coles, S. J.; Derveni, M.; Wright, E.; Marrison, L.; Lee, A. A.; Morris, A.; Robinson, M.; von Delft, F.; Fearon, D.; Koekemoer, L.; Matviuk, T.; Aimon, A.; Schofield, C. J.; Malla, T. R.; London, N.; Greenland, B. W.; Bagley, M. C.; Spencer, J.; The Covid Moonshot Consortium. Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds. ChemMedChem 2022, 17, e202100641. doi:10.1002/cmdc.202100641
• Rensch, T.; Fabig, S.; Graetz, S.; Borchardt, L. Mechanochemically-assisted Synthesis of Polyimides. ChemSusChem 2021, 15, e202101975. doi:10.1002/cssc.202101975
• Andersen, J.; Starbuck, H. F.; Current, T.; Martin, S. T.; Mack, J. Milligram-scale, temperature-controlled ball milling to provide an informed basis for scale-up to reactive extrusion. Green Chemistry 2021, 23, 8501–8509. doi:10.1039/d1gc02174e
• Rathmann, T.; Petersen, H.; Reichle, S.; Schmidt, W.; Amrute, A. P.; Etter, M.; Weidenthaler, C. In situ synchrotron x-ray diffraction studies monitoring mechanochemical reactions of hard materials: Challenges and limitations. The Review of scientific instruments 2021, 92, 114102. doi:10.1063/5.0068627

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