Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

Livia Polgár, Eszter Lajkó, Pál Soós, Orsolya Láng, Marilena Manea, Béla Merkely, Gábor Mező and László Kőhidai
Beilstein J. Org. Chem. 2018, 14, 1583–1594. https://doi.org/10.3762/bjoc.14.136

Supporting Information

Supporting Information File 1: Experimental part – synthesis.
Format: PDF Size: 384.0 KB Download
Supporting Information File 2: Supplementary tables – comparative data of short- and long-term effects of GnRH-drug conjugates on cardiomyocytes and endothelial cells.
Format: PDF Size: 537.7 KB Download

Cite the Following Article

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells
Livia Polgár, Eszter Lajkó, Pál Soós, Orsolya Láng, Marilena Manea, Béla Merkely, Gábor Mező and László Kőhidai
Beilstein J. Org. Chem. 2018, 14, 1583–1594. https://doi.org/10.3762/bjoc.14.136

How to Cite

Polgár, L.; Lajkó, E.; Soós, P.; Láng, O.; Manea, M.; Merkely, B.; Mező, G.; Kőhidai, L. Beilstein J. Org. Chem. 2018, 14, 1583–1594. doi:10.3762/bjoc.14.136

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 1.1 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Szász, Z.; Enyedi, K. N.; Takács, A.; Fekete, N.; Mező, G.; Kőhidai, L.; Lajkó, E. Characterisation of the cell and molecular biological effect of peptide-based daunorubicin conjugates developed for targeting pancreatic adenocarcinoma (PANC-1) cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024, 173, 116293. doi:10.1016/j.biopha.2024.116293
  • Moiseeva, A. A.; Artyushin, O. I.; Anikina, L. V.; Globa, A. A.; Klemenkova, Z. S.; Andreev, M. V.; Radchenko, E. V.; Palyulin, V. A.; Brel, V. K. Design of anthracyclines with extremely high cytotoxic properties. Research Square Platform LLC 2024. doi:10.21203/rs.3.rs-3942818/v1
  • Mező, G.; Gomena, J.; Ranđelović, I.; Dókus, E. L.; Kiss, K.; Pethő, L.; Schuster, S.; Vári, B.; Vári-Mező, D.; Lajkó, E.; Polgár, L.; Kőhidai, L.; Tóvári, J.; Szabó, I. Oxime-Linked Peptide-Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy: An Overview. International journal of molecular sciences 2024, 25, 1864. doi:10.3390/ijms25031864
  • Feng, J.; Wu, Y. Endothelial-to-Mesenchymal Transition: Potential Target of Doxorubicin-Induced Cardiotoxicity. American journal of cardiovascular drugs : drugs, devices, and other interventions 2023, 23, 231–246. doi:10.1007/s40256-023-00573-w
  • Balogh, B.; Ivánczi, M.; Nizami, B.; Beke-Somfai, T.; Mándity, I. M. ConjuPepDB: a database of peptide-drug conjugates. Nucleic acids research 2020, 49, D1102–D1112. doi:10.1093/nar/gkaa950
  • Kurmi, B. D.; Paliwal, R.; Paliwal, S. R. Dual cancer targeting using estrogen functionalized chitosan nanoparticles loaded with doxorubicin-estrone conjugate: A quality by design approach. International journal of biological macromolecules 2020, 164, 2881–2894. doi:10.1016/j.ijbiomac.2020.08.172
  • Takasuna, K.; Kazusa, K.; Hayakawa, T. Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi). Current pharmaceutical biotechnology 2020, 21, 829–841. doi:10.2174/1389201020666191024172425
  • Piorecka, K.; Smith, D. R. R.; Kurjata, J.; Stanczyk, M.; Stanczyk, W. A. Synthetic routes to nanoconjugates of anthracyclines. Bioorganic chemistry 2020, 96, 103617. doi:10.1016/j.bioorg.2020.103617
  • Sun, X.; Liu, J.; Wang, Y.; Bai, X.; Chen, Y.; Qian, J.; Zhu, H.; Liu, F.; Qiu, X.; Sun, S.; Ji, N.; Liu, Y. Methotrexate-cytarabine-dexamethasone combination chemotherapy with or without rituximab in patients with primary central nervous system lymphoma. Oncotarget 2017, 8, 49156–49164. doi:10.18632/oncotarget.17101
Other Beilstein-Institut Open Science Activities