Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids

Eszter Lajkó, Sarah Spring, Rózsa Hegedüs, Beáta Biri-Kovács, Sven Ingebrandt, Gábor Mező and László Kőhidai
Beilstein J. Org. Chem. 2018, 14, 2495–2509. https://doi.org/10.3762/bjoc.14.226

Supporting Information

Supporting Information File 1: Experimental.
Format: PDF Size: 280.0 KB Download
Supporting Information File 2: Analytical parameters and cell biological effects of Dau–GnRH-III conjugates.
Format: PDF Size: 686.5 KB Download

Cite the Following Article

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids
Eszter Lajkó, Sarah Spring, Rózsa Hegedüs, Beáta Biri-Kovács, Sven Ingebrandt, Gábor Mező and László Kőhidai
Beilstein J. Org. Chem. 2018, 14, 2495–2509. https://doi.org/10.3762/bjoc.14.226

How to Cite

Lajkó, E.; Spring, S.; Hegedüs, R.; Biri-Kovács, B.; Ingebrandt, S.; Mező, G.; Kőhidai, L. Beilstein J. Org. Chem. 2018, 14, 2495–2509. doi:10.3762/bjoc.14.226

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 641.0 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Felegyi-Tóth, C. A.; Heilmann, T.; Buda, E.; Stipsicz, B.; Simon, A.; Boldizsár, I.; Bősze, S.; Riethmüller, E.; Alberti, Á. Evaluation of the Chemical Stability, Membrane Permeability and Antiproliferative Activity of Cyclic Diarylheptanoids from European Hornbeam (Carpinus betulus L.). International journal of molecular sciences 2023, 24, 13489. doi:10.3390/ijms241713489
  • Jaye, K.; Chang, D.; Li, C. G.; Bhuyan, D. J. Gut Metabolites and Breast Cancer: The Continuum of Dysbiosis, Breast Cancer Risk, and Potential Breast Cancer Therapy. International journal of molecular sciences 2022, 23, 9490. doi:10.3390/ijms23169490
  • Chen, C.-P.; Lu, X. Gonadotropin-releasing hormone receptor inhibits triple-negative breast cancer proliferation and metastasis. The Journal of international medical research 2022, 50, 3000605221082895–030006052210828. doi:10.1177/03000605221082895
  • Kalabay, M.; Szász, Z.; Láng, O.; Lajkó, E.; Pállinger, É.; Duró, C.; Jernei, T.; Csámpai, A.; Takács, A.; Kőhidai, L. Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines. Pharmaceuticals (Basel, Switzerland) 2022, 15, 314. doi:10.3390/ph15030314
  • Jaye, K.; Li, C. G.; Chang, D.; Bhuyan, D. J. The role of key gut microbial metabolites in the development and treatment of cancer. Gut microbes 2022, 14, 2038865. doi:10.1080/19490976.2022.2038865
  • Berek-Nagy, P. J.; Tóth, G.; Bősze, S.; Horváth, L.; Darcsi, A.; Csíkos, S.; Knapp, D. G.; Kovács, G. M.; Boldizsár, I. The grass root endophytic fungus Flavomyces fulophazii: An abundant source of tetramic acid and chlorinated azaphilone derivatives. Phytochemistry 2021, 190, 112851. doi:10.1016/j.phytochem.2021.112851
  • Balogh, B.; Ivánczi, M.; Nizami, B.; Beke-Somfai, T.; Mándity, I. M. ConjuPepDB: a database of peptide-drug conjugates. Nucleic acids research 2020, 49, D1102–D1112. doi:10.1093/nar/gkaa950
  • Jernei, T.; Duró, C.; Dembo, A.; Lajkó, E.; Takács, A.; Kőhidai, L.; Schlosser, G.; Csámpai, A. Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona-Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers. Molecules (Basel, Switzerland) 2019, 24, 4077. doi:10.3390/molecules24224077
  • Lajkó, E.; Hegedüs, R.; Mező, G.; Kőhidai, L. Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells. International journal of molecular sciences 2019, 20, 4421. doi:10.3390/ijms20184421
  • Schuster, S.; Biri-Kovács, B.; Szeder, B.; Buday, L.; Gardi, J.; Szabó, Z.; Halmos, G.; Mező, G. Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification. Pharmaceutics 2018, 10, 223. doi:10.3390/pharmaceutics10040223

Patents

  • CSÁMPAI ANTAL; BÁRÁNY PÉTER; CZUCZI TAMÁS; KOVÁCS IMRE; ADAMIS BÁLINT; NÉMETH ZSÓFIA; MURÁNYI JÓZSEF; OLÁHNÉ SZABÓ RITA; BŐSZE SZILVIA; MEZŐ GÁBOR; KŐHIDAI LÁSZLÓ; LAJKÓ ESZTER; TAKÁCS ANGÉLA; LÁNG ORSOLYA; MEZŐ DIÁNA. SYNTHESIS OF NOVEL IMIPRIDONE DERIVATIVES AND THEIR EVALUATION FOR THEIR ANTICANCER ACTIVITY. WO 2022029459 A1, Feb 10, 2022.
Other Beilstein-Institut Open Science Activities