6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

Scholarly Works

• Bege, M.; Herczeg, M.; Bereczki, I.; Debreczeni, N.; Bényei, A.; Herczegh, P.; Borbás, A. Triaza-tricyclanos - synthesis of a new class of tricyclic nucleoside analogues by stereoselective cascade cyclocondensation. Organic & biomolecular chemistry 2023, 21, 2213–2219. doi:10.1039/d3ob00154g
• Lowe, P. T.; O'Hagan, D. 4'-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics. Chemical Society reviews 2023, 52, 248–276. doi:10.1039/d2cs00762b
• Freund, N.; Fürst, M. J. L. J.; Holliger, P. New chemistries and enzymes for synthetic genetics. Current opinion in biotechnology 2021, 74, 129–136. doi:10.1016/j.copbio.2021.11.004
• Yamaguchi, T.; Yamamoto, C.; Horiba, M.; Aoyama, H.; Obika, S. Synthesis and duplex-forming ability of oligonucleotides modified with 4'-C,5'-C-methylene-bridged nucleic acid (4',5'-BNA). Bioorganic & medicinal chemistry 2021, 46, 116359. doi:10.1016/j.bmc.2021.116359
• Akabane-Nakata, M.; Erande, N. D.; Kumar, P.; Degaonkar, R.; Gilbert, J. A.; Qin, J.; Mendez, M.; Woods, L. B.; Jiang, Y.; Janas, M. M.; O'Flaherty, D. K.; Zlatev, I.; Schlegel, M. K.; Matsuda, S.; Egli, M.; Manoharan, M. siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs. Nucleic acids research 2021, 49, 2435–2449. doi:10.1093/nar/gkab050
• Yamani, K.; Pierre, H.; Archambeau, A.; Meyer, C.; Cossy, J. Asymmetric Transfer Hydrogenation of gem-Difluorocyclopropenyl Esters: Access to Enantioenriched gem-Difluorocyclopropanes. Angewandte Chemie (International ed. in English) 2020, 59, 18505–18509. doi:10.1002/anie.202008572
• Yamani, K.; Pierre, H.; Archambeau, A.; Meyer, C.; Cossy, J. Asymmetric Transfer Hydrogenation of gem ‑Difluorocyclopropenyl Esters: Access to Enantioenriched gem ‑Difluorocyclopropanes. Angewandte Chemie 2020, 132, 18663–18667. doi:10.1002/ange.202008572
• Volochnyuk, D. M.; Grygorenko, O. O. Emerging Fluorinated Motifs; Wiley, 2020; pp 135–194. doi:10.1002/9783527824342.ch5
• Moai, Y.; Kodama, T. Recent developments of artificial functional oligo nucleic acids. Tetrahedron Letters 2020, 61, 151708. doi:10.1016/j.tetlet.2020.151708
• Akabane-Nakata, M.; Kumar, P.; Das, R. S.; Erande, N. D.; Matsuda, S.; Egli, M.; Manoharan, M. Synthesis and Biophysical Characterization of RNAs Containing 2′-Fluorinated Northern Methanocarbacyclic Nucleotides. Organic letters 2019, 21, 1963–1967. doi:10.1021/acs.orglett.8b04153
• Frei, S.; Katolik, A.; Leumann, C. J. Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA. Beilstein journal of organic chemistry 2019, 15, 79–88. doi:10.3762/bjoc.15.9

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