Liquid-assisted grinding and ion pairing regulates percentage conversion and diastereoselectivity of the Wittig reaction under mechanochemical conditions

Scholarly Works

• Mitra, A. K.; Das, A.; Bhar, A. From mortars to mills: mechanochemistry as a tool for efficient organic transformations. Journal of the Iranian Chemical Society 2026, 23. doi:10.1007/s13738-026-03381-6
• Baykova, S. O.; Solodyankina, O. V.; Baykov, S. V.; Cilcic, A.; Ignatov, E. V.; Kryukova, S. S.; Islamova, R. M.; Boyarskiy, V. P. Mechanochemical Approach for Amidoxime Synthesis. Asian Journal of Organic Chemistry 2026, 15. doi:10.1002/ajoc.70331
• Panthi, K.; Umar, S.; Wachira, J.; Samokhvalov, A. Pharmaceutical Binary and Ternary Complexes of Gemcitabine with Aluminum Metal–Organic Framework: Mechano-Chemical Encapsulation, Delayed Drug Release, and Toxicity to Pancreatic Cells. Pharmaceutics 2026, 18, 170. doi:10.3390/pharmaceutics18020170
• Breinsperger, J.; Podlesnik, N.; Mele, F.; Schnürch, M. Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis. Chemistry (Weinheim an der Bergstrasse, Germany) 2026, e03536. doi:10.1002/chem.202503536
• Poljanić, L.; Leyssens, T.; Collard, L.; Baier, D. M. When chirality breaks: mechanochemical degradation of biaryl atropisomers. RSC Mechanochemistry 2026. doi:10.1039/d5mr00132c
• Karmakar, I.; Chatterjee, S.; Das, S.; Brahmachari, A.; Das, G.; Choudhuri, T.; Brahmachari, G. Functionalized Diphenyl (2-Oxochroman-4-yl)phosphonates: Dual Synthetic Approaches, Mechanistic Insights, and Exploration of a Promising Anti-Lung Cancerous Molecule. Synlett 2025, 37, 522–530. doi:10.1055/a-2725-5792
• Gallego, A.; Pétry, N.; Pinaud, J.; Giani, O.; Lamaty, F. Easier, Safer, and Greener: Unlocking the Power of Solid Reagents in Organic Reactions by Mechanochemistry. ChemistryEurope 2025, 4. doi:10.1002/ceur.202500232
• Kumar, S.; Button-Jennings, D.; Hanusa, T. P.; Martini, A. Solvent influence on the mechanism of a mechanochemical metal-halide metathesis reaction. RSC Mechanochemistry 2025, 2, 529–537. doi:10.1039/d4mr00136b
• Umar, S.; Catazaro, J.; Wachira, J.; Samokhvalov, A. Mechano-chemical encapsulation of gemcitabine hydrochloride on metal-organic framework, preparation of shaped pellets, delayed drug release, and time-dependent toxicity to PANC-1 cancer cells. Journal of drug delivery science and technology 2025, 111, 107195. doi:10.1016/j.jddst.2025.107195
• Templ, J.; Schnürch, M. Hochenergetisches Kugelmahlen ermöglicht eine ultraschnelle Wittig‐Olefinierung unter atmosphärischen und lösungsmittelfreien Bedingungen. Angewandte Chemie 2024, 136. doi:10.1002/ange.202411536
• Templ, J.; Schnürch, M. High-Energy Ball Milling Enables an Ultra-Fast Wittig Olefination Under Ambient and Solvent-free Conditions. Angewandte Chemie (International ed. in English) 2024, 63, e202411536. doi:10.1002/anie.202411536
• Umar, S.; Welch, X.; Obichere, C.; Carter-Cooper, B.; Samokhvalov, A. Interaction of 6-Thioguanine with Aluminum Metal-Organic Framework Assisted by Mechano-Chemistry, In Vitro Delayed Drug Release, and Time-Dependent Toxicity to Leukemia Cells. Nanomaterials (Basel, Switzerland) 2024, 14, 1571. doi:10.3390/nano14191571
• Barik, P.; Pal, C. K.; Chakraborty, S.; Azad, S. A.; Patra, P.; Jana, R.; Molla, M. R.; Samanta, S. NaBH4‐Induced Chemoselective Mechanochemical Neat Synthesis of Bio‐Active Dihydrofuran/ϵ‐Hydroxy‐α,β‐Unsaturated Esters and Synthetic Application to Isoindoles. European Journal of Organic Chemistry 2024, 27. doi:10.1002/ejoc.202400534
• Kubota, K.; Hisazumi, R.; Seo, T.; Ito, H. Mechanochemistry enabled highly efficient solvent-free deoxygenation of phosphine oxides in air. RSC Mechanochemistry 2024, 1, 250–254. doi:10.1039/d4mr00011k
• Umar, S.; Samokhvalov, A. Encapsulation of Gemcitabine on Porphyrin Aluminum Metal-Organic Framework by Mechano-Chemistry, Delayed Drug Release and Cytotoxicity to Pancreatic Cancer PANC-1 Cells. Molecules (Basel, Switzerland) 2024, 29, 3189. doi:10.3390/molecules29133189
• Michalska-Walkowiak, J.; SN Antonio, E.; Coumes, F.; Rieger, J.; Terrasson, V.; Pourceau, G.; Wadouachi, A.; Jeux, V. Mechanosynthesis and Polymerization of Biosourced Styrene Derivatives Based on Building Blocks of Lignin. ACS Sustainable Chemistry & Engineering 2024, 12, 2577–2587. doi:10.1021/acssuschemeng.3c06050
• Marrett, J. M.; Titi, H. M.; Teoh, Y.; Friščić, T. Supramolecular "baking powder": a hexameric halogen-bonded phosphonium salt cage encapsulates and functionalises small-molecule carbonyl compounds. Chemical science 2023, 15, 298–306. doi:10.1039/d2sc04615f
• Henry, B.; Samokhvalov, A. Characterization of tautomeric forms of anti-cancer drug gemcitabine and their interconversion upon mechano-chemical treatment, using ATR-FTIR spectroscopy and complementary methods. Journal of pharmaceutical and biomedical analysis 2023, 226, 115243. doi:10.1016/j.jpba.2023.115243
• Breilly, D.; Fadlallah, S.; Froidevaux, V.; Lamaty, F.; Allais, F.; Métro, T.-X. Sustainability and efficiency assessment of vanillin allylation: in solution versus ball-milling. Green Chemistry 2022, 24, 7874–7882. doi:10.1039/d2gc02185d
• Jiang, L.; Yan, S.; Dong, J.; Ye, L.; Cheng, Y.; Chu, X. Catalyst‐free one‐pot three‐component rapid synthesis of polysubstituted pyrroles by liquid‐assisted grinding. Journal of Heterocyclic Chemistry 2022, 59, 1561–1572. doi:10.1002/jhet.4490

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