Supporting Information
| Supporting Information File 1: Synthetic procedures, characterization data for novel compounds and copies of spectra; photostability assessment, conformational analysis of compound 2, and biological assays. | ||
| Format: PDF | Size: 2.4 MB | Download |
Cite the Following Article
Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity
Yuvixza Lizarme-Salas, Alexandra Daryl Ariawan, Ranjala Ratnayake, Hendrik Luesch, Angela Finch and Luke Hunter
Beilstein J. Org. Chem. 2020, 16, 2663–2670.
https://doi.org/10.3762/bjoc.16.216
How to Cite
Lizarme-Salas, Y.; Ariawan, A. D.; Ratnayake, R.; Luesch, H.; Finch, A.; Hunter, L. Beilstein J. Org. Chem. 2020, 16, 2663–2670. doi:10.3762/bjoc.16.216
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 11.5 MB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Niżnik, Ł.; Fijałkowska, O.; Jurowski, K. Toxicity of fentanyl (CAS: 437-38-7) and valerylfentanyl (CAS: 122882-90-0): the first integrative in silico toxicology study with clinical and forensic implications. Archives of toxicology 2025. doi:10.1007/s00204-025-04214-w
- Ryan, P.; Iftikhar, R.; Hunter, L. Origami with small molecules: exploiting the C-F bond as a conformational tool. Beilstein journal of organic chemistry 2025, 21, 680–716. doi:10.3762/bjoc.21.54
- Varala, R.; Seema, V.; Amanullah, M.; Ramanaiah, S.; Alam, M. M. Recent Advances in Hypervalent Iodine Reagents and m-CPBA Mediated Oxidative Transformations. Current Organic Chemistry 2024, 28, 489–509. doi:10.2174/0113852728296345240215111730
- Bhanukiran, K.; Singh, S. K.; Singh, R.; Kumar, A.; Hemalatha, S. Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease. ACS chemical neuroscience 2023, 14, 2743–2760. doi:10.1021/acschemneuro.3c00269
- Bacheley, L.; Molina Betancourt, R.; Ravindra, R.; Guillamot, G.; Phansavath, P.; Ratovelomanana‐Vidal, V. Asymmetric Synthesis of Monofluorinated Carbocyclic Alcohols and Vicinal Difluorinated Heterocycles and Carbocycles. European Journal of Organic Chemistry 2023, 26. doi:10.1002/ejoc.202300383
- Yu, C.; Piscelli, B. A.; Maharik, N. A.; Cordes, D. B.; Slawin, A. M. Z.; Cormanich, R. A.; O'Hagan, D. Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes. Chemical communications (Cambridge, England) 2022, 58, 12855–12858. doi:10.1039/d2cc05058g
- Piva, O. Comprehensive Heterocyclic Chemistry IV - Five-Membered Rings With Three Oxygen or Sulfur Atoms in 1,2,3-Positions. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; pp 120–145. doi:10.1016/b978-0-12-818655-8.00117-7
- Lizarme-Salas, Y.; Yu, T. T.; de Bruin-Dickason, C. N.; Kumar, N.; Hunter, L. Fluorinated quorum sensing inhibitors: enhancement of potency through conformational control. Organic & biomolecular chemistry 2021, 19, 9629–9636. doi:10.1039/d1ob01649k
- Cheng, X.; Ma, L. Enzymatic synthesis of fluorinated compounds. Applied microbiology and biotechnology 2021, 105, 8033–8058. doi:10.1007/s00253-021-11608-0
- Ariawan, A. D.; Mansour, F.; Richardson, N. L.; Bhadbhade, M. M.; Ho, J.; Hunter, L. The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors. Molecules (Basel, Switzerland) 2021, 26, 3974. doi:10.3390/molecules26133974
