Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

Luke O. Jones, Leah Williams, Tasmin Boam, Martin Kalmet, Chidubem Oguike and Fiona L. Hatton
Beilstein J. Org. Chem. 2021, 17, 2553–2569. https://doi.org/10.3762/bjoc.17.171

Cite the Following Article

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing
Luke O. Jones, Leah Williams, Tasmin Boam, Martin Kalmet, Chidubem Oguike and Fiona L. Hatton
Beilstein J. Org. Chem. 2021, 17, 2553–2569. https://doi.org/10.3762/bjoc.17.171

How to Cite

Jones, L. O.; Williams, L.; Boam, T.; Kalmet, M.; Oguike, C.; Hatton, F. L. Beilstein J. Org. Chem. 2021, 17, 2553–2569. doi:10.3762/bjoc.17.171

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 9.2 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Zhang, Y.; Yao, T.; Xu, R.; Ma, P.; Zhao, J.; Mi, Y. Biodegradable and Mechanically Resilient Recombinant Collagen/PEG/Catechol Cryogel Hemostat for Deep Non-Compressible Hemorrhage and Wound Healing. Gels (Basel, Switzerland) 2025, 11, 445. doi:10.3390/gels11060445
  • Priyadharshini, S.; Sujith, S.; Anuja, D.; Dhanya, R.; Moses, J.; Sinija, V. Fundamentals, Approaches and Emerging Applications of Cryogels in the Food Industry. Trends in Food Science & Technology 2025, 105159. doi:10.1016/j.tifs.2025.105159
  • Iakobson, O.; Ivan'kova, E.; Nashchekina, Y.; Vaganov, G.; Laishevkina, S.; Shevchenko, N. Effect of the Comonomer Nature on the Cytotoxicity and Mechanical Properties of a Cryogel Based on Sodium 2-Acrylamido-2-methyl-1-propanesulfonate Copolymers. Colloids and Interfaces 2025, 9, 34. doi:10.3390/colloids9030034
  • Li, M.; Wei, X.; You, J.; Feng, J.; Liu, X.; Zhou, J.; Wu, Q.; Zhang, Y.; Zhou, Y. Cryogels with controllable physico-chemical properties as advanced delivery systems for biomedical applications. Materials today. Bio 2025, 32, 101815. doi:10.1016/j.mtbio.2025.101815
  • Hoffmann, T.; Behrendt, F.; Dietz, L.; Holick, C. T.; Scharfenberg, P.; Gottschaldt, M.; Sigusch, B. W.; Schubert, U. S. Photoresponsive cryogels based on poly(2-oxazoline)s. European Polymer Journal 2025, 229, 113845. doi:10.1016/j.eurpolymj.2025.113845
  • Chand, R.; Kamei, K.-i.; Vijayavenkataraman, S. Advances in Microfluidic Bioprinting for Multi-Material Multi-Cellular Tissue Constructs. Cell Engineering & Therapy Connect 2025, 1, 1. doi:10.69709/cellengc.2024.111335
  • Vishwkarma, A.; Bajpai, J.; Bajpai, A. K. Hemoglobin-Polyvinyl Alcohol (Hb-PVA) Macroporous Cryogels As Swelling-Controlled Drug Delivery System Optimization and Release Kinetics of Vancomycin. Journal of Pharmaceutical Innovation 2025, 20. doi:10.1007/s12247-024-09909-8
  • D'Amora, U.; Scialla, S.; Fasolino, I.; Ronca, A.; Soriente, A.; De Cesare, N.; Manini, P.; Phua, J. W.; Pezzella, A.; Raucci, M. G.; Ambrosio, L. Eumelanin pigment release from photo-crosslinkable methacrylated gelatin-based cryogels: Exploring the physicochemical properties and antioxidant efficacy in wound healing. Biomaterials advances 2025, 170, 214214. doi:10.1016/j.bioadv.2025.214214
  • Mishra Tiwari, R.; Channey, H. S.; Jain, E. Interpenetrating Polymer Network of Hydroxyethyl Methacrylate and Chitosan as Cryogels for Tissue Engineering Applications. Polymers for Advanced Technologies 2025, 36. doi:10.1002/pat.70055
  • Lorente, A.; Sturm, J. S.; Kleoff, M.; Lorenz, F.; Voßnacker, P.; Wagner, O.; Haag, R.; Riedel, S. Polyethyleneimine-Based Cryogels Enabling the Selective and Reversible Adsorption of Chlorine. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024, 12, e2414274. doi:10.1002/advs.202414274
  • Iakobson, O. D.; Shevchenko, N. N.; Laishevkina, S. G.; Ivan'kova, E. M.; Volkov, A. I.; Kondratiev, V. V. Sulfocontaining polyelectrolyte cryogels as metamaterials for energy storage devices. Polymer International 2024, 74, 377–385. doi:10.1002/pi.6729
  • Reece, B.; Bahar, E. V.; Pereira, A. C.; Witek, L.; Kita, K. A Simple Staining Method Using Pyronin Y for Laser Scanning Confocal Microscopy to Evaluate Gelatin Cryogels. Bio-protocol 2024, 14, e5115.
  • Castanheira, E. J.; Rodrigues, J. M. M.; Mano, J. F. Cryogels Composites: Recent Improvement in Bone Tissue Engineering. Nano letters 2024, 24, 13875–13887. doi:10.1021/acs.nanolett.4c03197
  • Karakoç, V.; Bektaş, H.; Turkmen, D.; Denizli, A. Removal of As (V) from Water with Cryogels Prepared By Molecular Imprinting Technique. Hacettepe Journal of Biology and Chemistry 2024, 52, 217–236. doi:10.15671/hjbc.1446425
  • Sousa, J. P. M.; Deus, I. A.; Monteiro, C. F.; Custódio, C. A.; Stratakis, E.; Mano, J. F.; Marques, P. A. A. P. Comparative analysis of aligned and random amniotic membrane-derived cryogels for neural tissue repair. Biomaterials science 2024, 12, 4393–4406. doi:10.1039/d4bm00364k
  • Zhang, K.; Yang, Z.; Seitz, M. P.; Jain, E. Macroporous PEG-Alginate Hybrid Double-Network Cryogels with Tunable Degradation Rates Prepared via Radical-Free Cross-Linking for Cartilage Tissue Engineering. ACS applied bio materials 2024, 7, 5925–5938. doi:10.1021/acsabm.4c00091
  • Patole, V.; Ingavle, G.; Behere, I.; Nehere, T.; Kolhe, P.; Baheti, R.; Swami, D. Emerging trends in polysaccharide based cryogel scaffold for skin tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials 2024, 74, 1008–1026. doi:10.1080/00914037.2024.2387028
  • Santos, J. B.; Porfirio, M. C. P.; Santos, M. P. F.; Souza, Y. G. d.; Bonomo, R. C. F.; Fontan, R. d. C. I. Development of a glutamate-functionalized macroporous cation-exchange matrix for partial purification of lysozyme from chicken egg white. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2024, 694, 134224. doi:10.1016/j.colsurfa.2024.134224
  • Mukasheva, F.; Moazzam, M.; Yernaimanova, B.; Shehzad, A.; Zhanbassynova, A.; Berillo, D.; Akilbekova, D. Design and characterization of 3D printed pore gradient hydrogel scaffold for bone tissue engineering. Bioprinting 2024, 39, e00341. doi:10.1016/j.bprint.2024.e00341
  • Çimen, D.; Özbek, M. A.; Bereli, N.; Mattiasson, B.; Denizli, A. Injectable Functional Polymeric Cryogels for Biological Applications. Biomedical Materials & Devices 2024, 3, 288–298. doi:10.1007/s44174-024-00190-4
Other Beilstein-Institut Open Science Activities