Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

Scholarly Works

• Liu, Y.; Li, C.; Zhu, T.; Li, R.; Zhang, M.; Li, X.; Cai, D.; Dai, Z.; Wan, L.; Lu, H. Extracellular matrix-mimicking cryogels in tissue engineering and cancer therapy: from structural design to translational applications abstract. Journal of materials chemistry. B 2025, 13, 14166–14193. doi:10.1039/d5tb01412c
• Iordanescu, M. V.; Vintilă, A. C.; Psenovschi, G.; Capra, L.; Gavrilă, A.-M.; Enascuta, C. E.; Iordache, T.-V. Cryo-Structured Chitosan Sponges with Controlled Release Properties for Liquid Digestate as Potential Agricultural Fertilizers. Gels 2025, 11, 887. doi:10.3390/gels11110887
• Rizqullah, A. H.; Saylan, Y. Biomedical applications of extracellular vesicles (EVs): even better with cryogels. Mikrochimica acta 2025, 192, 753. doi:10.1007/s00604-025-07560-9
• Priyadharshini, S.; Sujith, S.; Divate, A.; Dhanya, G.; Moses, J.; Sinija, V. Fundamentals, approaches and emerging applications of cryogels in the food industry. Trends in Food Science & Technology 2025, 163, 105159. doi:10.1016/j.tifs.2025.105159
• Jain, E.; Zhang, K.; Mishra Tiwari, R. Properties and Characterization of Cryogels: Structural, Mechanical, and Functional Insights. ACS omega 2025, 10, 36771–36787. doi:10.1021/acsomega.5c02863
• Boruah, M.; Sarma, A. Dry Gels: Concept, Current Trends, and New Avenues in Drug Delivery and Biomedical Application. Advanced healthcare materials 2025, 14, e00863. doi:10.1002/adhm.202500863
• Gong, W.; Kim, J.; Kim, C.; Chang, H.; Ahn, Y.; Schaffer, D. V.; Baek, J. Hydrogel fabrication techniques for advanced artificial sensory systems. International Journal of Extreme Manufacturing 2025, 7, 62002–062002. doi:10.1088/2631-7990/ade8b8
• Zhang, Y.; Yao, T.; Xu, R.; Ma, P.; Zhao, J.; Mi, Y. Biodegradable and Mechanically Resilient Recombinant Collagen/PEG/Catechol Cryogel Hemostat for Deep Non-Compressible Hemorrhage and Wound Healing. Gels (Basel, Switzerland) 2025, 11, 445. doi:10.3390/gels11060445
• Iakobson, O.; Ivan'kova, E.; Nashchekina, Y.; Vaganov, G.; Laishevkina, S.; Shevchenko, N. Effect of the Comonomer Nature on the Cytotoxicity and Mechanical Properties of a Cryogel Based on Sodium 2-Acrylamido-2-methyl-1-propanesulfonate Copolymers. Colloids and Interfaces 2025, 9, 34. doi:10.3390/colloids9030034
• Li, M.; Wei, X.; You, J.; Feng, J.; Liu, X.; Zhou, J.; Wu, Q.; Zhang, Y.; Zhou, Y. Cryogels with controllable physico-chemical properties as advanced delivery systems for biomedical applications. Materials today. Bio 2025, 32, 101815. doi:10.1016/j.mtbio.2025.101815
• Hoffmann, T.; Behrendt, F.; Dietz, L.; Holick, C. T.; Scharfenberg, P.; Gottschaldt, M.; Sigusch, B. W.; Schubert, U. S. Photoresponsive cryogels based on poly(2-oxazoline)s. European Polymer Journal 2025, 229, 113845. doi:10.1016/j.eurpolymj.2025.113845
• Chand, R.; Kamei, K.-i.; Vijayavenkataraman, S. Advances in Microfluidic Bioprinting for Multi-Material Multi-Cellular Tissue Constructs. Cell Therapy & Engineering Connect 2025, 1, 1. doi:10.69709/cellengc.2024.111335
• Vishwkarma, A.; Bajpai, J.; Bajpai, A. K. Hemoglobin-Polyvinyl Alcohol (Hb-PVA) Macroporous Cryogels As Swelling-Controlled Drug Delivery System Optimization and Release Kinetics of Vancomycin. Journal of Pharmaceutical Innovation 2025, 20. doi:10.1007/s12247-024-09909-8
• D'Amora, U.; Scialla, S.; Fasolino, I.; Ronca, A.; Soriente, A.; De Cesare, N.; Manini, P.; Phua, J. W.; Pezzella, A.; Raucci, M. G.; Ambrosio, L. Eumelanin pigment release from photo-crosslinkable methacrylated gelatin-based cryogels: Exploring the physicochemical properties and antioxidant efficacy in wound healing. Biomaterials advances 2025, 170, 214214. doi:10.1016/j.bioadv.2025.214214
• Mishra Tiwari, R.; Channey, H. S.; Jain, E. Interpenetrating Polymer Network of Hydroxyethyl Methacrylate and Chitosan as Cryogels for Tissue Engineering Applications. Polymers for Advanced Technologies 2025, 36. doi:10.1002/pat.70055
• Lorente, A.; Sturm, J. S.; Kleoff, M.; Lorenz, F.; Voßnacker, P.; Wagner, O.; Haag, R.; Riedel, S. Polyethyleneimine-Based Cryogels Enabling the Selective and Reversible Adsorption of Chlorine. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024, 12, e2414274. doi:10.1002/advs.202414274
• Iakobson, O. D.; Shevchenko, N. N.; Laishevkina, S. G.; Ivan'kova, E. M.; Volkov, A. I.; Kondratiev, V. V. Sulfocontaining polyelectrolyte cryogels as metamaterials for energy storage devices. Polymer International 2024, 74, 377–385. doi:10.1002/pi.6729
• Reece, B.; Bahar, E. V.; Pereira, A. C.; Witek, L.; Kita, K. A Simple Staining Method Using Pyronin Y for Laser Scanning Confocal Microscopy to Evaluate Gelatin Cryogels. Bio-protocol 2024, 14, e5115.
• Castanheira, E. J.; Rodrigues, J. M. M.; Mano, J. F. Cryogels Composites: Recent Improvement in Bone Tissue Engineering. Nano letters 2024, 24, 13875–13887. doi:10.1021/acs.nanolett.4c03197
• Karakoç, V.; Bektaş, H.; Turkmen, D.; Denizli, A. Removal of As (V) from Water with Cryogels Prepared By Molecular Imprinting Technique. Hacettepe Journal of Biology and Chemistry 2024, 52, 217–236. doi:10.15671/hjbc.1446425

Explore citations to this article at