The preparation and properties of 1,1-difluorocyclopropane derivatives

Scholarly Works

• Cao, J.; Veytia-Bucheli, J. I.; Vincent, S. P. Synthesis of gem -Difluoro Spirocyclic Cyclopropyl Mannosyl-1-phosphate Analogues and Chemoenzymatic Preparation of ADP- and GDP-Spirocyclopropyl-mannose. Organic Letters 2026. doi:10.1021/acs.orglett.6c00767
• Liu, L.; Zhi, Y.; Hong, X.; Gao, M.; Jiang, L.; Han, Y.; Hou, H.; Zhu, S. Cs2CO3-Mediated Chemoselective Gem-Dihalocyclopropanation of 1,3-Enynes. Chemistry, an Asian journal 2026, 21, e70705. doi:10.1002/asia.70705
• Teng, Y.; Xue, Y.; Cai, M.; Zhong, Y.; Li, H. Palladium‐Catalyzed Defluorinative Chalcogenation of gem ‐Difluorocyclopropanes. Advanced Synthesis & Catalysis 2026, 368. doi:10.1002/adsc.70360
• Lu, W.; Liang, G.; Wu, J.; Lv, L. Palladium-Catalyzed Ring-Opening/Defluorinative Annulation of gem-Difluorocyclopropanes With β-Keto Sulfones: Synthesis of Multi-Substituted Furans. Chemistry (Weinheim an der Bergstrasse, Germany) 2026, e70879. doi:10.1002/chem.70879
• Su, J.; Liu, W.; Wang, J.; Luo, W.; Ma, Y.; Lv, L.; Li, Z. Palladium-catalyzed ring-opening defluorinative cross-coupling of gem‑difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane. Chinese Chemical Letters 2026, 37, 111288. doi:10.1016/j.cclet.2025.111288
• Morisaki, K.; Murakami, A.; Sato, Y. gem-Difluorocyclopropane Synthesis by Copper-Catalyzed C(sp3)-H Addition of 1,3-Dioxolane to Difluorocyclopropenes. Chemical & pharmaceutical bulletin 2025, 73, 1112–1116. doi:10.1248/cpb.c25-00582
• Fuchibe, K.; Nakayama, H.; Yamagiwa, A.; Idate, H.; Fujita, T.; Ichikawa, J. Selective CF Bond Activation in 1,1‐Difluorocyclopropanes: Synthesis of Functionalized Monofluoroalkenes. European Journal of Organic Chemistry 2025, 28. doi:10.1002/ejoc.202500697
• Lu, W.; Chen, K.; Lv, L.; Li, Z. Palladium-Catalyzed Cascade Cross-Coupling/Retro-Claisen Reaction of CF3-Substituted β-Diketones with gem-Difluorocyclopropanes. The Journal of organic chemistry 2025, 90, 13323–13332. doi:10.1021/acs.joc.5c01788
• Wong, Z. R.; Mai, B. K.; Berg, W. R.; Kvitsinski, A.; Correia, T. L. F.; Zhang, Y.; Liu, P.; Toste, F. D. Reactions of Difluorocarbene with Organogold(I) Complexes: Synthesis of Gem‐Difluoromethylene Organometallics via Difluorocarbene Insertion and Cycloaddition Reactions. Angewandte Chemie 2025, 137. doi:10.1002/ange.202511941
• Wong, Z. R.; Mai, B. K.; Berg, W. R.; Kvitsinski, A.; Correia, T. L. F.; Zhang, Y.; Liu, P.; Toste, F. D. Reactions of Difluorocarbene with Organogold(I) Complexes: Synthesis of Gem-Difluoromethylene Organometallics via Difluorocarbene Insertion and Cycloaddition Reactions. Angewandte Chemie (International ed. in English) 2025, 64, e202511941. doi:10.1002/anie.202511941
• Che, L.; Wang, X.; Sun, C.; Ge, Y.; Gao, M.; Jiang, X.; Xia, Y.; Hu, F. Access to gem-Diindolylcyclopropanes via Double Indolylation of gem-Difluorocyclopropanes. The Journal of organic chemistry 2025, 90, 11613–11625. doi:10.1021/acs.joc.5c01262
• Han, X.; Liu, X.; Len, C.; Liu, L.; Duan, X.-H.; Hu, M. Visible-light-driven gem-difluorocyclopropanation of gem-difluoroalkenes with diazo compounds. Tetrahedron 2025, 180, 134653. doi:10.1016/j.tet.2025.134653
• Goto, T.; Shirai, S.; Kawasaki-Takasuka, T.; Agou, T.; Yamazaki, T. I2-mediated convenient ring-opening of simple gem-difluorocyclopropanes. Organic & biomolecular chemistry 2025, 23, 3163–3170. doi:10.1039/d5ob00128e
• Yang, Z.-Q.; Gong, Y.; Gu, Q.; You, S.-L. Rhodium-Catalyzed Asymmetric Allylic Dearomatization of β-Naphthols with gem-Difluorinated Cyclopropanes. ACS Catalysis 2025, 15, 4287–4293. doi:10.1021/acscatal.5c00315
• Liu, W.; Ma, Y.; Huang, Q.; Sheng, J.; Lv, L.; Li, Z. Pd-IPent-Catalyzed Defluorinative Annulation of gem-Difluorocyclopropanes with Enamides: Synthesis of Multisubstituted N-H Pyrroles. Organic letters 2025, 27, 2151–2156. doi:10.1021/acs.orglett.5c00241
• Ma, Y.; Xu, B.; Zhang, H.; Li, Z. Palladium-catalyzed NHC ligand-controlled regiodivergent allyl-fluoroallyl cross-couplings. Organic Chemistry Frontiers 2025, 12, 760–765. doi:10.1039/d4qo01800a
• Fuchibe, K.; Mitsumori, M.; Ishikawa, K.; Ichikawa, J. Synthesis of Monofluoroalkene-Based Dipeptide Bioisosteres via Regioselective Ring Opening of 1,1-Difluorocyclopropanes. Synthesis 2025, 57, 1506–1516. doi:10.1055/a-2509-5342
• Shivanyuk, A.; Lukin, O.; Dolgonos, G.; Gerasov, A.; Mandzhulo, A.; Fetyukhin, V. Spirocyclizations of Nortropanes. Synthesis 2024, 57, 1375–1401. doi:10.1055/a-2503-2459
• Lv, L.; Su, J.; Li, Z. Recent developments in the ring-opening transformations of gem-difluorocyclopropanes. Organic Chemistry Frontiers 2024, 11, 6518–6533. doi:10.1039/d4qo01583e
• Su, J.; Qian, H.; Wen, G.; Hu, M.; Lv, L.; Li, Z. Pd/IPrBIDEA‐Catalyzed Synthesis of Pyrroles via Cascade C−C/C−F Cleavage/Annulation of gem‐Difluorocyclopropanes. Asian Journal of Organic Chemistry 2024, 13. doi:10.1002/ajoc.202400469

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