¹⁹F NMR as a tool in chemical biology

Scholarly Works

• Burridge, C.; Burmann, B. M. 19 F NMR as a Molecular Reporter: Labelling Strategies and Methods for Probing Biomolecular Motion and Exchange. Chemistry–Methods 2026, 6. doi:10.1002/cmtd.202500155
• Norman, S. M.; Xu, J.; Yoon, L.; Rhoades, D.; Cheng, M.; Kelly, J. W. 19F NMR Interpretation Complications with 3-Bromo-1,1,1-Trifluoroacetone (BTFA) and an Alternative 2-Iodo-N-(2,2,2-Trifluoroethyl)acetamide (ITFEA) 19F NMR Probe. Analytical chemistry 2026, 98, 3566–3576. doi:10.1021/acs.analchem.5c04609
• Chiou, S.-L.; Lin, J.; Miao, J.; Tsai, Y.-H.; Chiu, C.-W.; Lin, Y.-S.; Chu, J. Mechanism of action of a boron-dependent antibiotic entails synergistic binding. RSC advances 2026, 16, 4549–4554. doi:10.1039/d5ra09403h
• Vairoletti, F.; Rodríguez, P.; Cantero, J.; Paulino, M.; Alvarez, N.; Ellena, J.; Salinas, G.; Hernández Dossi, G.; Mahler, G.; Saiz, C. An integrated NMR and DFT study on the conformational preferences of N-alkyl benzamides. Elsevier BV 2026. doi:10.2139/ssrn.6315400
• Karamanis, P.; Kiernan, M.; Muldoon, J.; Evans, P.; Murphy, C. D.; Rubini, M. Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity. ChemPlusChem 2025, 91, e202500590. doi:10.1002/cplu.202500590
• Álvarez-Mena, A.; Berbon, M.; Di Primo, C.; Garcia-Fandino, R.; Piñeiro, Á.; Fernandez-Lozano, C.; Filipe, H. A.; Habenstein, B. Exploiting the synergy between computational and experimental biophysics for efficient cancer drug development. European Journal of Medicinal Chemistry Reports 2025, 16, 100320. doi:10.1016/j.ejmcr.2025.100320
• Huang, B.; Lu, S.; Wu, Q.; Liu, Y. Recent advances in spectroscopic chiral analysis of carboxylic acids. Talanta 2025, 299, 129155. doi:10.1016/j.talanta.2025.129155
• Hanson, G. S. M.; Batsaki, F.; Myerscough, T. L.; Piché, K.; Louwrier, A.; Coxon, C. R. 19F NMR-tags for peptidyl prolyl conformation analysis. RSC chemical biology 2025, 6, 1740–1748. doi:10.1039/d5cb00118h
• Krishnappa, R.; Shit, S.; Dey, P.; Nayak, A.; Sahoo, D. K.; Shaik, K.; Sonti, R.; Raghothama, S.; Gowd, K. H. Comparative Study of UVA Filtering Compounds 2‑Methyl/2-Amino Pyrimidine Derivatives of Avobenzone under Acidic Conditions. ACS omega 2025, 10, 50139–50152. doi:10.1021/acsomega.5c06701
• Ramirez-Cordero, B.; Traaseth, N. J. Quantification of Membrane Protein Conformational Free Energy from Mutations and a Single Atom. Journal of the American Chemical Society 2025, 147, 34316–34326. doi:10.1021/jacs.5c04065
• Karamanis, P.; Kiernan, M.; Muldoon, J.; Doyle, F.; Evans, P.; Murphy, C. D.; Rubini, M. Novel Synthesis of the Antifungal Cyclic Lipopeptide Iturin A and Its Fluorinated Analog for Structure-Activity Relationship Studies. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e01341. doi:10.1002/chem.202501341
• Ukhanev, S. A.; Rusakov, Y. Y.; Rusakova, I. L. A Quest for Effective 19F NMR Spectra Modeling: What Brings a Good Balance Between Accuracy and Computational Cost in Fluorine Chemical Shift Calculations?. International journal of molecular sciences 2025, 26, 6930. doi:10.3390/ijms26146930
• Roy, S.; Srivatsan, S. G. Probing SARS-CoV-2 G-Quadruplexes in the Nsp3 Gene Segment by Fluorescence and 19F NMR Using a Functionalized Nucleoside Analog. Bioconjugate chemistry 2025, 36, 1661–1669. doi:10.1021/acs.bioconjchem.5c00157
• Jakob, L.; van der Wal, J. J.; Tovtik, R.; Copko, J.; Iagatti, A.; Donato, M. D.; Crespi, S.; Simeth, N. A. Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e202501856. doi:10.1002/chem.202501856
• Alimowska, O. A.; Khan, A.; Prosser, R. S. Advances in the application of NMR to the study of GPCRs and ligand-GPCR interactions. Expert opinion on drug discovery 2025, 20, 973–989. doi:10.1080/17460441.2025.2515045
• Cui, C.-Y.; Li, B.; Zhang, X.; Guo, S.-L.; Pan, B.-B.; Su, X.-C. Visualization and Quantification of Base-Level SO2 in Live Cells without Intracellular Background Interference Using Sensitive 19F-NMR. Journal of the American Chemical Society 2025, 147, 19893–19901. doi:10.1021/jacs.5c04351
• Chang, C.; Dargaville, B. L.; Momot, K. I.; Hutmacher, D. W. 19F NMR Relaxometry and Diffusometry for Measuring Cargo Molecule Dynamics in GelMA Hydrogels. Macromolecular Materials and Engineering 2025, 310. doi:10.1002/mame.202400348
• Kang, C. 19F NMR in RNA structural biology: exploring structures, dynamics, and small molecule interactions. European journal of medicinal chemistry 2025, 292, 117682. doi:10.1016/j.ejmech.2025.117682
• Li, M.; Xu, G.; Gong, Z.; Wu, Q.; Jiang, L.; Li, C. Simultaneous measurement of multiple fluorine labelling effect on GB1 stability by 19F NMR. Talanta 2025, 292, 127959. doi:10.1016/j.talanta.2025.127959
• Droemer, M. A.; Shein, M.; Schütz, A. K. Choice of ATP Analogues for Biophysical Studies—A Systematic NMR-Based Investigation for the AAA Enzyme p97. Biophysica 2025, 5, 9. doi:10.3390/biophysica5010009

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