¹⁹F NMR as a tool in chemical biology

Scholarly Works

• Ludwig, J.; Watzenborn, T.; Laschat, S.; Weiss, I. M. Synthetic iminosugar monomers change global metabolic pathways and chitin biosynthesis in Thalassiosira rotula. openRxiv 2026. doi:10.64898/2026.07.09.737548
• Un, S.; Garda, Z.; Mihovilcevic, D.; Tibiletti, T.; Tóth, É. Mn(II) 19F Electron-Nuclear Double Resonance Spectroscopy as a Structural Tool: Resolution of the Structural Diversity of a Mn(II) Dual 19F/1H MRI Probe. Journal of the American Chemical Society 2026, 148, 23686–23697. doi:10.1021/jacs.6c00899
• Priyadarshi, A.; Miller, A.-F. 19F NMR probes of conformational change in a bifurcating electron transfer flavoprotein. Biophysical journal 2026, 125, 3439–3455. doi:10.1016/j.bpj.2026.05.024
• Vairoletti, F.; Rodríguez, P.; Cantero, J.; Paulino, M.; Alvarez, N.; Ellena, J.; Salinas, G.; Dossi, G. H.; Mahler, G.; Saiz, C. An integrated NMR and DFT study on the conformational preferences of N-alkyl benzamides. Journal of Molecular Structure 2026, 1371, 146455. doi:10.1016/j.molstruc.2026.146455
• Xu, L.-H.; Wang, Y.-K.; Chen, Y.-T.; Su, X.-C. Solvent-assisted sensing ability of 19F reporter in simultaneous discrimination and quantification of proline and 4-hydroxyproline isomers. Talanta 2026, 308, 129769. doi:10.1016/j.talanta.2026.129769
• Álvarez-Mena, A.; Berbon, M.; Di Primo, C.; Garcia-Fandino, R.; Piñeiro, Á.; Fernandez-Lozano, C.; Filipe, H. A.; Habenstein, B. Exploiting the synergy between computational and experimental biophysics for efficient cancer drug development. European Journal of Medicinal Chemistry Reports 2026, 16, 100320. doi:10.1016/j.ejmcr.2025.100320
• Burridge, C.; Burmann, B. M. 19 F NMR as a Molecular Reporter: Labelling Strategies and Methods for Probing Biomolecular Motion and Exchange. Chemistry–Methods 2026, 6. doi:10.1002/cmtd.202500155
• Norman, S. M.; Xu, J.; Yoon, L.; Rhoades, D.; Cheng, M.; Kelly, J. W. 19F NMR Interpretation Complications with 3-Bromo-1,1,1-Trifluoroacetone (BTFA) and an Alternative 2-Iodo-N-(2,2,2-Trifluoroethyl)acetamide (ITFEA) 19F NMR Probe. Analytical chemistry 2026, 98, 3566–3576. doi:10.1021/acs.analchem.5c04609
• Chiou, S.-L.; Lin, J.; Miao, J.; Tsai, Y.-H.; Chiu, C.-W.; Lin, Y.-S.; Chu, J. Mechanism of action of a boron-dependent antibiotic entails synergistic binding. RSC advances 2026, 16, 4549–4554. doi:10.1039/d5ra09403h
• Vairoletti, F.; Rodríguez, P.; Cantero, J.; Paulino, M.; Alvarez, N.; Ellena, J.; Salinas, G.; Hernández Dossi, G.; Mahler, G.; Saiz, C. An integrated NMR and DFT study on the conformational preferences of N-alkyl benzamides. Elsevier BV 2026. doi:10.2139/ssrn.6315400
• Xu, L.-H.; Wang, Y.-K.; Chen, Y.-T.; Su, X.-C. S. Solvent-Assisted Sensing Ability of 19F Reporter in Simultaneous Discrimination and Quantification of Proline and 4-Hydroxyproline Isomers. Elsevier BV 2026. doi:10.2139/ssrn.6403494
• Karamanis, P.; Kiernan, M.; Muldoon, J.; Evans, P.; Murphy, C. D.; Rubini, M. Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity. ChemPlusChem 2025, 91, e202500590. doi:10.1002/cplu.202500590
• Huang, B.; Lu, S.; Wu, Q.; Liu, Y. Recent advances in spectroscopic chiral analysis of carboxylic acids. Talanta 2025, 299, 129155. doi:10.1016/j.talanta.2025.129155
• Hanson, G. S. M.; Batsaki, F.; Myerscough, T. L.; Piché, K.; Louwrier, A.; Coxon, C. R. 19F NMR-tags for peptidyl prolyl conformation analysis. RSC chemical biology 2025, 6, 1740–1748. doi:10.1039/d5cb00118h
• Krishnappa, R.; Shit, S.; Dey, P.; Nayak, A.; Sahoo, D. K.; Shaik, K.; Sonti, R.; Raghothama, S.; Gowd, K. H. Comparative Study of UVA Filtering Compounds 2‑Methyl/2-Amino Pyrimidine Derivatives of Avobenzone under Acidic Conditions. ACS omega 2025, 10, 50139–50152. doi:10.1021/acsomega.5c06701
• Ramirez-Cordero, B.; Traaseth, N. J. Quantification of Membrane Protein Conformational Free Energy from Mutations and a Single Atom. Journal of the American Chemical Society 2025, 147, 34316–34326. doi:10.1021/jacs.5c04065
• Karamanis, P.; Kiernan, M.; Muldoon, J.; Doyle, F.; Evans, P.; Murphy, C. D.; Rubini, M. Novel Synthesis of the Antifungal Cyclic Lipopeptide Iturin A and Its Fluorinated Analog for Structure-Activity Relationship Studies. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e01341. doi:10.1002/chem.202501341
• Ukhanev, S. A.; Rusakov, Y. Y.; Rusakova, I. L. A Quest for Effective 19F NMR Spectra Modeling: What Brings a Good Balance Between Accuracy and Computational Cost in Fluorine Chemical Shift Calculations?. International journal of molecular sciences 2025, 26, 6930. doi:10.3390/ijms26146930
• Roy, S.; Srivatsan, S. G. Probing SARS-CoV-2 G-Quadruplexes in the Nsp3 Gene Segment by Fluorescence and 19F NMR Using a Functionalized Nucleoside Analog. Bioconjugate chemistry 2025, 36, 1661–1669. doi:10.1021/acs.bioconjchem.5c00157
• Jakob, L.; van der Wal, J. J.; Tovtik, R.; Copko, J.; Iagatti, A.; Donato, M. D.; Crespi, S.; Simeth, N. A. Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e202501856. doi:10.1002/chem.202501856

Explore citations to this article at