Synthetic accesses to biguanide compounds

Scholarly Works

• Sharifirad, F.; Khodaei, M. M. Immobilization of Copper NPs on a Nitrogen-Rich Platform from Polymerization of UiO-66-NH2 with 1,4-Phenylene bis(Cyanoguanidine): A Post-modification Approach Towards Catalysis of Polyhydroquinoline and Tetrahydrobenzo[b]pyran Derivatives. Catalysis Letters 2025, 155. doi:10.1007/s10562-025-05230-2
• Mutalabisin, M. F.; Chee, C. F.; Rashid, N. N.; Johan, M. R.; Ghaffari Khaligh, N. Highly stable twist-boat conformer of piperazine-1,4-carboximidamide hydrochloride hydrate: Synthesis, characterization, and study of geometry and thermal behavior. Journal of Molecular Structure 2025, 1348, 143446. doi:10.1016/j.molstruc.2025.143446
• Yu, J.-L.; Wang, W.-Y.; Chiou, J.-C.; Yung, K.-F.; Kan, C.-W. Simultaneous dyeing and wastewater treatment in one bath by constructing cationic polyelectrolyte self-assembled coating onto cellulosic fabrics. Sustainable Chemistry and Pharmacy 2025, 45, 102028. doi:10.1016/j.scp.2025.102028
• Grytsai, O.; Hamouda-Tekaya, N.; Gonçalves, L. C. P.; Bardovskyi, R.; Abbe, P.; Benhida, R.; Rocchi, S.; Ronco, C. Optimised arylbiamidine derivative as potent in vivo antimelanoma agent: Drug-to-target approach reveals nanomolar GSK3β inhibition. Bioorganic chemistry 2025, 158, 108315. doi:10.1016/j.bioorg.2025.108315
• Yang, C.; Wang, W.; Liu, P.; Tao, P.; Cao, H.; Yung, K.-F.; Kan, C.-W. Uncovering the Screening-Enhanced Behavior of Poly(hexamethylene biguanide) Hydrochloride in Overcoming Charge Screening Limitations. The Journal of Physical Chemistry C 2025, 129, 2691–2700. doi:10.1021/acs.jpcc.4c07047
• Qi, R.; Lei, J.; Dong, L.; Tumrani, S. H.; Feng, C. In situ self-cleaning removal of emerging organic contaminants with covalent organic framework armed with arylbiguanide. Journal of hazardous materials 2025, 486, 137073. doi:10.1016/j.jhazmat.2024.137073
• Rahn, H. P.; Liu, X.; Chosy, M. B.; Sun, J.; Cegelski, L.; Wender, P. A. Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria. Journal of the American Chemical Society 2024, 146, 22541–22552. doi:10.1021/jacs.4c06520
• Perinelli, D. R.; Del Bello, F.; Vitali, L. A.; Nabissi, M.; Cespi, M.; Quaglia, W.; Aguzzi, C.; Lupetti, V.; Giangrossi, M.; Bonacucina, G. Dual function surfactants for pharmaceutical formulations: The case of surface active and antibacterial 1-tolyl alkyl biguanide derivatives. International journal of pharmaceutics 2024, 661, 124388. doi:10.1016/j.ijpharm.2024.124388
• Raczyńska, E. D.; Gal, J.-F.; Maria, P.-C. Strong Bases and beyond: The Prominent Contribution of Neutral Push-Pull Organic Molecules towards Superbases in the Gas Phase. International journal of molecular sciences 2024, 25, 5591. doi:10.3390/ijms25115591
• Lockwood, T. D. Coordination chemistry suggests that independently observed benefits of metformin and Zn2+ against COVID-19 are not independent. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2024, 37, 983–1022. doi:10.1007/s10534-024-00590-5
• Wang, W.-Y.; Hu, H.-W.; Chiou, J.-C.; Yung, K.-F.; Kan, C.-W. Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application. Polymer Chemistry 2023, 14, 5226–5252. doi:10.1039/d3py01148h
• Shi, X.; Zhang, R.; Sand, W.; Mathivanan, K.; Zhang, Y.; Wang, N.; Duan, J.; Hou, B. Comprehensive Review on the Use of Biocides in Microbiologically Influenced Corrosion. Microorganisms 2023, 11, 2194. doi:10.3390/microorganisms11092194
• Makotchenko, E. V.; Yu. Kharlamova, V.; Baidina, I. A.; Bardina, E. E.; Korolkov, I. V.; Mironov, I. V.; Gushchin, A. L. Synthesis, crystal structure and solution studies of gold(III) complexes with 1,1-dimethylbiguanide. Inorganica Chimica Acta 2023, 552, 121496. doi:10.1016/j.ica.2023.121496
• Koneshlou, T.; Rouhani, M.; Saeidian, H.; Aliabad, J. M. Biguanide-dihydropyrimidine dual scaffolds with impressive basicities according to DFT calculations. Computational and Theoretical Chemistry 2023, 1225, 114178. doi:10.1016/j.comptc.2023.114178
• Bi, C.; Wang, Y.; He, C.; Baran, P. S. Enantioselective Total Synthesis of (+)-KB343. Journal of the American Chemical Society 2023, 145, 7753–7757. doi:10.1021/jacs.3c01991
• Gungor, O.; Kose, M. Design, synthesis, biological evaluation and molecular docking of cyclic biguanidine compounds as cholinesterase inhibitors. Journal of biomolecular structure & dynamics 2022, 41, 10885–10899. doi:10.1080/07391102.2022.2158945
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• Güngör, Ö.; Köse, M. Design, synthesis and biological evaluation of biguanids and biguanid-sulfonamides as cholinesterase inhibitors. Journal of Molecular Structure 2022, 1260, 132817. doi:10.1016/j.molstruc.2022.132817
• Grytsai, O.; Myrgorodska, I.; Rocchi, S.; Ronco, C.; Benhida, R. Biguanides drugs: Past success stories and promising future for drug discovery. European journal of medicinal chemistry 2021, 224, 113726. doi:10.1016/j.ejmech.2021.113726

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