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Efficacy of radical reactions of isocyanides with heteroatom radicals in organic synthesis

Akiya Ogawa and Yuki Yamamoto

Beilstein J. Org. Chem. 2024, 20, 2114–2128. https://doi.org/10.3762/bjoc.20.182

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Akiya Ogawa and Yuki Yamamoto

Beilstein J. Org. Chem. 2024, 20, 2114–2128. https://doi.org/10.3762/bjoc.20.182

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Ogawa, A.; Yamamoto, Y. Beilstein J. Org. Chem. 2024, 20, 2114–2128. doi:10.3762/bjoc.20.182

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TY  - JOUR
A1  - Ogawa, Akiya
A1  - Yamamoto, Yuki
T1  - Efficacy of radical reactions of isocyanides with heteroatom radicals in organic synthesis
JF  - Beilstein Journal of Organic Chemistry
PY  - 2024///
VL  - 20
SP  - 2114
EP  - 2128
SN  - 1860-5397
DO  - 10.3762/bjoc.20.182
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.20.182
KW  - aza-Bergman cyclization
KW  - heteroatom-mixed system
KW  - imidoyl radical
KW  - isocyanide
KW  - radical addition
KW  - radical cyclization
N2  - Isocyanide is a promising synthetic reagent not only as a one-carbon homologation reagent but also as a nitrogen source for nitrogen-containing molecules. Because of their isoelectronic structure with carbon monoxide, isocyanides also react with nucleophiles, electrophiles, carbon radicals, and transition metal reagents, and are widely used in organic synthesis. On the other hand, the use of isocyanides in reactions with heteroatom radicals is limited. However, the reaction of isocyanides with heteroatom radicals is a promising synthetic tool for the construction of nitrogen-containing organic molecules modified with a variety of heteroatoms. In this Perspective, we review the addition and cyclization reactions of heteroatom radicals with isocyanides and discuss the synthetic prospects of the reaction of isocyanides with heteroatom radicals.
ER  -

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
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“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
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