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Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

Dmitriy Yu. Vandyshev, Daria A. Mangusheva, Khidmet S. Shikhaliev, Kirill A. Scherbakov, Oleg N. Burov, Alexander D. Zagrebaev, Tatiana N. Khmelevskaya, Alexey S. Trenin and Fedor I. Zubkov

Beilstein J. Org. Chem. 2024, 20, 2806–2817. https://doi.org/10.3762/bjoc.20.236

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Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

Dmitriy Yu. Vandyshev, Daria A. Mangusheva, Khidmet S. Shikhaliev, Kirill A. Scherbakov, Oleg N. Burov, Alexander D. Zagrebaev, Tatiana N. Khmelevskaya, Alexey S. Trenin and Fedor I. Zubkov

Beilstein J. Org. Chem. 2024, 20, 2806–2817. https://doi.org/10.3762/bjoc.20.236

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Vandyshev, D. Y.; Mangusheva, D. A.; Shikhaliev, K. S.; Scherbakov, K. A.; Burov, O. N.; Zagrebaev, A. D.; Khmelevskaya, T. N.; Trenin, A. S.; Zubkov, F. I. Beilstein J. Org. Chem. 2024, 20, 2806–2817. doi:10.3762/bjoc.20.236

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TY  - JOUR
A1  - Vandyshev, Dmitriy Yu.
A1  - Mangusheva, Daria A.
A1  - Shikhaliev, Khidmet S.
A1  - Scherbakov, Kirill A.
A1  - Burov, Oleg N.
A1  - Zagrebaev, Alexander D.
A1  - Khmelevskaya, Tatiana N.
A1  - Trenin, Alexey S.
A1  - Zubkov, Fedor I.
T1  - Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines
JF  - Beilstein Journal of Organic Chemistry
PY  - 2024///
VL  - 20
SP  - 2806
EP  - 2817
SN  - 1860-5397
DO  - 10.3762/bjoc.20.236
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.20.236
KW  - 2-aminoimidazole
KW  - antimycotic activity
KW  - imidazo[1,2-a]pyrimidine
KW  - molecular docking
KW  - N-arylitaconimides
KW  - N-substituted maleimides
KW  - recyclization
N2  - The heterocyclic core of imidazo[1,2-a]pyrimidine was formed in satisfactory yields as a result of the interaction of the readily available 2-aminoimidazole with N-substituted maleimides or N-arylitaconimides. The mechanism of the studied processes was postulated basing on experimental data, HPLC–MS analysis of reaction mixtures, and quantum chemical calculations. Molecular docking results of the obtained imidazo[1,2-a]pyrimidines, when compared with voriconazole, a drug already in clinical use, suggest that they may possess antifungal activity against Candida albicans.
ER  -

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Scholarly Works

Sroor, F. M.; El‐Sayed, A. F.; Abdelraof, M. Investigation of New Biologically Active Benzo[4,5]imidazo[1,2‐a]pyrimidine Derivatives as Broad‐Spectrum Antimicrobial Agents: Synthesis, Anti‐Biofilm, ROS and in Silico Studies. Drug Development Research 2025, 86. doi:10.1002/ddr.70096

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