Cycloaddition reactions of heterocyclic azides with 2-cyanoacetamidines as a new route to C,N-diheteroarylcarbamidines

Pavel S. Silaichev, Tetyana V. Beryozkina, Vsevolod V. Melekhin, Valeriy O. Filimonov, Andrey N. Maslivets, Vladimir G. Ilkin, Wim Dehaen and Vasiliy A. Bakulev

Beilstein J. Org. Chem. 2024, 20, 17–24. https://doi.org/10.3762/bjoc.20.3

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Chemical structure C<sub>16</sub>H<sub>18</sub>N<sub>8</sub>O<sub>2</sub>

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Extracted from

Scheme 2

Chemical Information

Calculated using the Chemistry Development Kit 2.12

Property Name	Property Value
Molecular Formula	C₁₆H₁₈N₈O₂
Molecular Weight	354.37 g/mol
Exact Mass	354.1553 Da
InChI	InChI=1S/C16H18N8O2/c1-22-11(8-12(25)23(2)16(22)26)19-14(17)13-15(18)24(21-20-13)9-10-6-4-3-5-7-10/h3-8H,9,18H2,1-2H3,(H2,17,19)
InChIKey	SJISCOFJDJXJRL-UHFFFAOYSA-N
SMILES	CN1C(=CC(=O)N(C)C1=O)/N=C(/C2=C(N)N(CC3=CC=CC=C3)N=N2)\N
Number of Atoms	44
Number of H-Bond Acceptors	10
Number of H-Bond Donors	2
Atoms in the Largest π-System	17
XLogP	-0.9

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Operator	Resulting query
aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)