Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition
Beth L. Ritchie, Alexandra Longcake and Iain Coldham
Beilstein J. Org. Chem. 2025, 21, 1890–1896.
https://doi.org/10.3762/bjoc.21.146
Chemical Information
Calculated using the Chemistry Development Kit 2.12
| Molecular Formula | C22H19N3O4 |
| Molecular Weight | 389.40 g/mol |
| Exact Mass | 389.1375 Da |
| InChI |
InChI=1S/C22H19N3O4/c1-23-15-10-6-5-9-14(15)22(21(23)28)11-16-17-18(29-24(16)12-22)20(27)25(19(17)26)13-7-3-2-4-8-13/h2-10,16-18H,11-12H2,1H3
|
| InChIKey |
BEBLCPCBHQTVPI-UHFFFAOYSA-N
|
| SMILES |
CN1C2=C(C=CC=C2)C3(CC4C5C(C(=O)N(C6=CC=CC=C6)C5=O)ON4C3)C1=O
|
| Number of Atoms | 48 |
| Number of H-Bond Acceptors | 5 |
| Number of H-Bond Donors | 0 |
| Atoms in the Largest π-System | 11 |
| XLogP | -0.5 |
