Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition

Beth L. Ritchie, Alexandra Longcake and Iain Coldham
Beilstein J. Org. Chem. 2025, 21, 1890–1896. https://doi.org/10.3762/bjoc.21.146
Chemical structure C<sub>6</sub>H<sub>8</sub>O<sub>4</sub>

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Chemical Information

Calculated using the Chemistry Development Kit 2.12
Molecular Formula C6H8O4
Molecular Weight 144.13 g/mol
Exact Mass 144.0423 Da
InChI
InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3-
InChIKey
LDCRTTXIJACKKU-ARJAWSKDSA-N
SMILES
COC(=O)/C=C\C(=O)OC
Number of Atoms 18
Number of H-Bond Acceptors 4
Number of H-Bond Donors 0
Atoms in the Largest π-System 8
XLogP 0.2
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