Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

Scholarly Works

• Anchan, H. N.; Naik C, P.; Bhat, N. S.; Kumari, M.; Dutta, S. Efficient Synthesis of Novel Biginelli and Hantzsch Products Sourced from Biorenewable Furfurals Using Gluconic Acid Aqueous Solution as the Green Organocatalyst. ACS omega 2023, 8, 34077–34083. doi:10.1021/acsomega.3c05106
• Bhat, N. S.; Kumari, M.; Naik C, P.; Mal, S. S.; Dutta, S. Synthesis of novel Biginelli and Hantzsch products from biorenewable furfurals using 1,4‐diazabicyclo[2.2.2]octanium diacetate as a Brønsted acidic ionic liquid catalyst. ChemistrySelect 2023, 8. doi:10.1002/slct.202301782
• Anjirwala, S. N.; Parmar, P. S.; Patel, S. K. Synthetic protocols for non-fused pyrimidines. Synthetic Communications 2022, 52, 2079–2121. doi:10.1080/00397911.2022.2137682
• Handique, S.; Sharma, P. One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives. Results in Chemistry 2022, 4, 100411. doi:10.1016/j.rechem.2022.100411
• Patil, R. V.; Chavan, J. U.; Dalal, D. S.; Shinde, V. S.; Beldar, A. G. Biginelli Reaction: Polymer Supported Catalytic Approaches. ACS combinatorial science 2019, 21, 105–148. doi:10.1021/acscombsci.8b00120
• Shumaila, A. M. A.; Al-Thulaia, A. A. N. Mini-review on the synthesis of Biginelli analogs using greener heterogeneous catalysis: Recent strategies with the support or direct catalyzing of inorganic catalysts. Synthetic Communications 2018, 49, 1613–1632. doi:10.1080/00397911.2018.1536789
• Mulder, D. J.; Liang, T.; Xu, Y.; Schiphorst, J. t.; Scheres, L. M. W.; Oosterlaken, B. M.; Borneman, Z.; Nijmeijer, K.; Schenning, A. P. H. J. Proton conductive cationic nanoporous polymers based on smectic liquid crystal hydrogen-bonded heterodimers. Journal of Materials Chemistry C 2018, 6, 5018–5024. doi:10.1039/c8tc00857d
• Lambat, T. L.; Deo, S.; Butle, A. B. Plasma marker based hepatoprotective evaluation of some novel synthesized benzofluorenone analogues: A medicinal chemistry approach. Karbala International Journal of Modern Science 2017, 3, 39–45. doi:10.1016/j.kijoms.2017.02.002
• Novina, J. J.; Vasuki, G.; Suresh, M.; Viswanathan, V.; Velmurugan, D. Ethyl 4-(furan-2-yl)-6-methyl-2-oxo-1,2,3,4-tetra­hydro­pyrimidine-5-carboxyl­ate: a triclinic polymorph. IUCrData 2016, 1. doi:10.1107/s2414314616019374
• Susick, R. B.; Morrill, L. A.; Picazo, E.; Garg, N. K. Pardon the Interruption: A Modification of Fischer's Venerable Reaction for the Synthesis of Heterocycles and Natural Products. Synlett : accounts and rapid communications in synthetic organic chemistry 2016, 28, 1–11. doi:10.1055/s-0036-1588372
• Kothandapani, J.; Ganesan, A.; Mani, G. K.; Kulandaisamy, A. J.; Rayappan, J. B. B.; Ganesan, S. S. Zinc oxide surface: a versatile nanoplatform for solvent-free synthesis of diverse isatin derivatives. Tetrahedron Letters 2016, 57, 3472–3475. doi:10.1016/j.tetlet.2016.06.094
• Lim, Z.; Duggan, P. J.; San Wan, S.; Lessene, G.; Meyer, A. G.; Tuck, K. L. Exploiting the Biginelli reaction: nitrogen-rich pyrimidine-based tercyclic α-helix mimetics. Tetrahedron 2016, 72, 1151–1160. doi:10.1016/j.tet.2015.12.044
• Andleeb, S.; Imtiaz-ud-Din; Rauf, M.; Azam, S. S.; Badshah, A.; Sadaf, H.; Raheel, A.; Tahir, M.; Raza, S. A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation. RSC Advances 2016, 6, 79651–79661. doi:10.1039/c6ra19162b
• Yu, J.
• Dhumaskar, K. L.; Meena, S. N.; Ghadi, S. C.; Tilve, S. G. Graphite catalyzed solvent free synthesis of dihydropyrimidin-2(1H)-ones/thiones and their antidiabetic activity. Bioorganic & medicinal chemistry letters 2014, 24, 2897–2899. doi:10.1016/j.bmcl.2014.04.099
• Hatamjafari, F. An Efficient One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Bismuth (III) Sulfate Trihydrate under Solvent-Free Conditions. Organic Chemistry International 2014, 2014, 106–110.
• Hatamjafari, F. An Efficient One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Bismuth (III) Sulfate Trihydrate under Solvent-Free Conditions. Organic Chemistry International 2014, 2014, 1–5. doi:10.1155/2014/761209
• Kolvari, E.; Mirzaeeyan, M. Al(NO3)3 · 9H2O: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Both under Reflux or Solvent-Free Conditions. Journal of Chemistry 2013, 2013, 1–5. doi:10.1155/2013/325268
• de Vasconcelos, A.; Oliveira, P. S.; Ritter, M.; Freitag, R. A.; Romano, R. L.; Quina, F. H.; Pizzuti, L.; Pereira, C. M. P.; Stefanello, F. M.; Barschak, A. G. Antioxidant capacity and environmentally friendly synthesis of dihydropyrimidin-(2H)-ones promoted by naturally occurring organic acids. Journal of biochemical and molecular toxicology 2012, 26, 155–161. doi:10.1002/jbt.20424
• Panda, S. S.; Khanna, P.; Khanna, L. Biginelli Reaction: A Green Perspective. Current Organic Chemistry 2012, 16, 507–520. doi:10.2174/138527212799499859

Explore citations to this article at