The C–F bond as a conformational tool in organic and biological chemistry

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• Freitas, M. P. Effect of fluorination of cyclohexanes on electrostatic interactions and unconventional C–F···H–C hydrogen bonding. Journal of Fluorine Chemistry 2026, 292, 110587. doi:10.1016/j.jfluchem.2026.110587
• Santos Oliveira, D. A.; Rodrigues Silva, D.; Braga, A. A. C.; Fonseca Guerra, C.; Perutz, R. N.; Eisenstein, O.; Bickelhaupt, F. M. How fluorine substituents strengthen aryl C-H bonds. Chemical science 2026, 17, 11390–11402. doi:10.1039/d6sc01846g
• wang, c.; Zhang, S.; Xu, S.; Wang, C.; Zhang, Z.; Sadeeq, M.; Wan, Y.; Gao, C.; Huang, W.; Xiong, P.; Hou, F. De novo biosynthesis and whole-cell production of alkoxylated phenazine derivatives. Springer Science and Business Media LLC 2026. doi:10.21203/rs.3.rs-9338442/v1
• Arora, H. S.; Dhakal, S.; Psarellis, Y.; Chandrasekaran, S.; Mavroudis, P. D.; Pillai, N. A Modular Machine Learning Framework for Small-Molecule Drug Repurposing Based on Organ Permeability, Target Binding, and Biomarker Modulation. openRxiv 2026. doi:10.64898/2026.04.14.718573
• Dalal, S.; Singh, D.; Aggarwal, V.; Malik, S.; Dalal, A.; Kumar, S.; Malik, R. S.; Kumar, P. Judd–Ofelt analyses and luminescence behavior of visible emitting trivalent Eu (III) complexes synthesized from 1-(4-bromophenyl)-4,4,4-trifluorobutane-1,3-dione and distinct ancillary ligands. Emergent Materials 2026, 9. doi:10.1007/s42247-026-01400-z
• Zhao, X.; Xiong, C.; Wu, Y.; Li, D.; Xu, Y.; Bai, Y.; Ji, H. Modulation of product distribution and mechanism study in naphthenate-catalyzed air oxidation of toluene. Journal of Catalysis 2026, 456, 116766. doi:10.1016/j.jcat.2026.116766
• Herrick, R. M.; Green, S. A.; Rich, S.; Grandner, J. M.; Huard, K.; Altman, R. A. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Compound Optimization: A Comparative Study. ACS medicinal chemistry letters 2026, 17, 721–726. doi:10.1021/acsmedchemlett.5c00757
• Menk, M.; Bläker, C.; Pasel, C.; Bathen, D. The influence of C-F- and C-H-bonds on the adsorption of propane and perfluoropropane on FAU-type zeolites. Microporous and Mesoporous Materials 2026, 402, 113988. doi:10.1016/j.micromeso.2025.113988
• Huo, Y.; Si, W.; Peng, H.; Jia, C.; Wang, J.; Guo, X. Stereoelectronic effects: From molecules to single-molecule devices. Coordination Chemistry Reviews 2026, 549, 217350. doi:10.1016/j.ccr.2025.217350
• Bhattarai, P.; Trombley, T. A.; Altman, R. A. Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective. Journal of medicinal chemistry 2026, 69, 1916–1941. doi:10.1021/acs.jmedchem.5c02359
• Malik, A. Q.; Kwang, C. Y.; Altarawneh, M.; Yeung, L. W. Y.; Teoh, W. Y. Persistence of aqueous-phase, short-chain per- and polyfluoroalkyl substances (PFAS) and their abatement by heterogeneous photocatalysis. Journal of Materials Chemistry A 2026. doi:10.1039/d6ta01866a
• Kasun, Z. A.; Liang, X.; Ferrao, R. D.; Kaplan, J. A.; Clark, C. T.; Neubig, M. E.; Byun, D. H.; Badal, S. S.; Sroda, N.; Mistry, T.; Stanley, N. H.; Stevens, K. L.; Bachman, J. L.; Lo, J. R.; Loyer-Drew, J.; Velasquez, M.; Hao, J.; Mwangi, J.; Stafford, B.; Jansa, P. The Discovery of GS-1291269: A Neutral Ketohexokinase (KHK) Inhibitor with an Unusual Thietane Amine Functional Group. Journal of medicinal chemistry 2025, 69, 501–516. doi:10.1021/acs.jmedchem.5c02896
• Richardson, P. Utility of fluorinated α-amino acids in development of therapeutic peptides. Expert opinion on drug discovery 2025, 21, 19–48. doi:10.1080/17460441.2025.2601105
• Mummadi, S.; Naulet, G.; Kauffmann, B.; Guichard, G.; Compain, G. Synthesis of (2S,4S)-5,5,5,5',5'-Pentafluoroleucine and (2S,4R)-5,5,5-Trifluoroleucine via Stereoselective Hydrogenation and Hydrodefluorination. The Journal of organic chemistry 2025, 91, 631–637. doi:10.1021/acs.joc.5c02700
• Wei, W.; Pradhan, P.; Veresmortean, C.; Neary, M. C.; Lakshman, M. K.; Khangarot, R. K.; Zajc, B. Modified Julia Olefination Approach to Chiral α-Fluorovinyl Amino Alcohols and Amino Acids, via Fluorovinyl Oxazolidine Precursors, Conformational and Crystallographic Analyses. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, e02269. doi:10.1002/chem.202502269
• Kaźmierczak, M.; Siodła, T.; Bilska‐Markowska, M. Regioselective Addition of Organolithium Reagents to Fluorinated Proline Amides: Insights from Experiment and Theory. ChemistrySelect 2025, 10. doi:10.1002/slct.202505278
• Freitas, M. P. Difluorinated Cyclohexanes: Energetics and Intra- and Intermolecular Interactions. Chemphyschem : a European journal of chemical physics and physical chemistry 2025, 26, e202500648. doi:10.1002/cphc.202500648
• Haskologlu, I. C.; Erdag, E.; Uludag, O. Can Piperazine-Bearing Fluoro-Benzoxazolone Derivatives Be a Chronotherapeutic Solution for Pain Management?. Chronobiology in Medicine 2025, 7, 154–161. doi:10.33069/cim.2025.0044
• Dai, X.; Ye, H.-M.; Huang, G.; Li, G. Structure-Tunable Fluorinated Polyester Electrolytes with Enhanced Interfacial Stability for Recyclable Solid-State Lithium Metal Batteries. Advanced materials (Deerfield Beach, Fla.) 2025, 38, e11556. doi:10.1002/adma.202511556

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