Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Scholarly Works

• Richardson, P. doi:10.1002/9783527824595.ch4
• Masson, E.; Maciejewski, E. M.; Wheelhouse, K. M. P.; Edwards, L. J. Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective. Organic Process Research & Development 2022, 26, 2190–2223. doi:10.1021/acs.oprd.2c00034
• Richardson, P.; Abdiaj, I. Drug Discovery Automation and Library Synthesis in Flow. Topics in Medicinal Chemistry; Springer International Publishing, 2021; pp 421–479. doi:10.1007/7355_2021_135
• Gambacorta, G.; Sharley, J. S.; Baxendale, I. R. A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries. Beilstein journal of organic chemistry 2021, 17, 1181–1312. doi:10.3762/bjoc.17.90
• Mohammadparast, F.; Tirumala, R. T. A.; Ramakrishnan, S. B.; Dadgar, A. P.; Andiappan, M. Operando UV–Vis spectroscopy as potential in-line PAT system for size determination of functioning metal nanocatalysts. Chemical Engineering Science 2020, 225, 115821. doi:10.1016/j.ces.2020.115821
• Cova, C. M.; Zuliani, A.; Manno, R.; Sebastian, V.; Luque, R. Scrap waste automotive converters as efficient catalysts for the continuous-flow hydrogenations of biomass derived chemicals. Green Chemistry 2020, 22, 1414–1423. doi:10.1039/c9gc04091a
• Navarro-Brull, F. J.; Teixeira, A. R.; Zhang, J.; Gómez, R.; Jensen, K. F. Reduction of Dispersion in Ultrasonically-Enhanced Micropacked Beds. Industrial & Engineering Chemistry Research 2017, 57, 122–128. doi:10.1021/acs.iecr.7b03876
• Baumann, M.; Baxendale, I. R.; Deplante, F. A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic. Beilstein journal of organic chemistry 2017, 13, 2549–2560. doi:10.3762/bjoc.13.251
• Lima, S.; Chadwick, D.; Hellgardt, K. Towards sustainable hydrogenation of 5-(hydroxymethyl)furfural: a two-stage continuous process in aqueous media over RANEY® catalysts. RSC Advances 2017, 7, 31401–31407. doi:10.1039/c7ra03318d
• Monguchi, Y.; Ichikawa, T.; Sajiki, H. Recent Development of Palladium-Supported Catalysts for Chemoselective Hydrogenation. Chemical & pharmaceutical bulletin 2017, 65, 2–9. doi:10.1248/cpb.c16-00153
• Mohamed, D. K. B.; Yu, X.; Li, J.; Wu, J. Reaction screening in continuous flow reactors. Tetrahedron Letters 2016, 57, 3965–3977. doi:10.1016/j.tetlet.2016.07.072
• Lövei, K.; Bana, P.; Örkényi, R.; Túrós, G. I.; Éles, J.; Novák, Z.; Faigl, F. Continuous flow synthesis of heterocyclic scaffolds: Design principles of multistep systems - A review. Chimica Oggi-chemistry Today 2016, 34, 18–21.
• Glasnov, T. N. Continuous-Flow Chemistry in the Research Laboratory - Organic Synthesis in Dedicated Continuous Flow Systems: Reductions and Oxidations. Continuous-Flow Chemistry in the Research Laboratory; Springer International Publishing, 2016; pp 49–67. doi:10.1007/978-3-319-32196-7_6
• Paun, C.; Słowik, G.; Lewin, E.; Sá, J. Flow hydrogenation of p-nitrophenol with nano-Ag/Al2O3. RSC Advances 2016, 6, 87564–87568. doi:10.1039/c6ra17512k
• Mallia, C. J.; Baxendale, I. R. The Use of Gases in Flow Synthesis. Organic Process Research & Development 2015, 20, 327–360. doi:10.1021/acs.oprd.5b00222
• Baumann, M.; Baxendale, I. R. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry. Beilstein journal of organic chemistry 2015, 11, 1194–1219. doi:10.3762/bjoc.11.134
• Hattori, T.; Ida, T.; Tsubone, A.; Sawama, Y.; Monguchi, Y.; Sajiki, H. Facile Arene Hydrogenation under Flow Conditions Catalyzed by Rhodium or Ruthenium on Carbon. European Journal of Organic Chemistry 2015, 2015, 2492–2497. doi:10.1002/ejoc.201500050
• Hsieh, C. T.; Ötvös, S. B.; Wu, Y. C.; Mándity, I. M.; Chang, F. R.; Fülöp, F. Highly Selective Continuous-Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives. ChemPlusChem 2015, 80, 859–864. doi:10.1002/cplu.201402426
• Osako, T.; Torii, K.; Tazawa, A.; Uozumi, Y. Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer. RSC Advances 2015, 5, 45760–45766. doi:10.1039/c5ra07563g
• Ager, D. J. ACS Symposium Series - Managing Hazardous Reactions and Compounds in Process Chemistry. ACS Symposium Series; American Chemical Society, 2014; pp 285–351. doi:10.1021/bk-2014-1181.ch012

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