Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

Scholarly Works

• Singh, S.; Srivastava, P. Secondary Metabolites of Cyanobacteria: A Focus on Nostoc Culture and Applications. Reference Series in Phytochemistry; Springer Nature Switzerland, 2026; pp 1–41. doi:10.1007/978-3-031-80866-1_42-1
• Yancey, C. E.; Hart, L. N.; Dick, G. J. Secondary metabolism of Microcystis: current understanding and recent advances in unlocking genomic and chemical diversity. Applied and environmental microbiology 2026, e0163425. doi:10.1128/aem.01634-25
• Sindhu, V.; Sharma, S.; Singh, S. S. Cyanobacteria as a source of secondary metabolites. Secondary Metabolites in Stress and Disease Management; Elsevier, 2026; pp 99–122. doi:10.1016/b978-0-443-33959-2.00002-2
• Chopade, A.; Kim, A. M.; Berthold, D. E.; Lefler, F. W.; Laughinghouse, H. D.; Bertin, M. J. Characterization of the Tychonamide Biosynthetic Pathway in the Recently Described Cyanobacterial Species Floridanema aerugineum. ACS chemical biology 2025, 20, 2649–2658. doi:10.1021/acschembio.5c00504
• Ojha, K.; Dubey, S.; Singh, A.; Kumar Dixit, A.; Kumari, P. Cyanobolites: Future Prospects in Therapeutics and Biological Innovation. Plant Secondary Metabolites - Occurrence, Structure and Role; IntechOpen, 2025. doi:10.5772/intechopen.1010149
• Hernández-Mejías, Á. D.; Jimenez-Nieves, G. D.; Caro-Diaz, E. J. E. In Silico Design and Analysis of Cyanobacterial Pseudo Natural Products. Journal of natural products 2025, 88, 1701–1709. doi:10.1021/acs.jnatprod.5c00439
• Philmus, B.; Avalon, N. E.; Ding, Y.; Doering, D. T.; Eustáquio, A. S.; Gerwick, W. H.; Luesch, H.; Orjala, J.; Sutherland, S.; Taton, A.; Udwary, D. Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery. Natural product reports 2025. doi:10.1039/d5np00016e
• Sabat, S.; Patra, S.; Swain, S.; Bej, S.; Bishoyi, A. K.; Sahoo, C. R.; Padhy, R. N. Phycocompounds from Cyanobacteria: Exploring Synergistic Effects with Conventional Anticancer and Antimicrobial Properties. ACS omega 2025, 10, 23957–23980. doi:10.1021/acsomega.5c03526
• Tsintzou, G.; Madesis, P. Peptide Elicitors for Defense Against Abiotic Stress. Plant Elicitor Peptides; Springer Nature Singapore, 2024; pp 19–47. doi:10.1007/978-981-97-6374-0_2
• Balogun, F. O.; Sabiu, S. Metabolites, Molecular Diversity, and Applications of Cyanobacteria in the Beverage Industry. Reference Series in Phytochemistry; Springer International Publishing, 2024; pp 447–482. doi:10.1007/978-3-031-38663-3_210
• Grabski, M.; Gawor, J.; Cegłowska, M.; Gromadka, R.; Mazur-Marzec, H.; Węgrzyn, G. Genome Mining of Pseudanabaena galeata CCNP1313 Indicates a New Scope in the Search for Antiproliferative and Antiviral Agents. Microorganisms 2024, 12, 1628. doi:10.3390/microorganisms12081628
• Yancey, C. E.; Hart, L.; Hefferan, S.; Mohamed, O. G.; Newmister, S. A.; Tripathi, A.; Sherman, D. H.; Dick, G. J. Metabologenomics reveals strain-level genetic and chemical diversity of Microcystis secondary metabolism. mSystems 2024, 9, e0033424. doi:10.1128/msystems.00334-24
• Kopriva, S.; Rahimzadeh Karvansara, P.; Takahashi, H. Adaptive modifications in plant sulfur metabolism over evolutionary time. Journal of experimental botany 2024, 75, 4697–4711. doi:10.1093/jxb/erae252
• Baunach, M.; Guljamow, A.; Miguel-Gordo, M.; Dittmann, E. Harnessing the potential: advances in cyanobacterial natural product research and biotechnology. Natural product reports 2024, 41, 347–369. doi:10.1039/d3np00045a
• Ramya, M.; Elumalai, S.; Umamaheswari, A. Analysis of cyanotoxins in Desertifilum and Leptolyngbya from Veeranam Lake: a potential health risk for Chennai, India. Environmental Sciences Europe 2024, 36. doi:10.1186/s12302-023-00791-8
• Karvansara, P. R.; Komenda, J.; Kopriva, S. Sulfur metabolism in cyanobacteria. Cyanobacteria; Elsevier, 2024; pp 117–157. doi:10.1016/b978-0-443-13231-5.00018-0
• Reehana, N.; Imran, M. Y. M.; Raja, M. I. M. M.; Thajuddin, N.; Dhanasekaran, D. NRPS and PKS Gene Analysis in Cyanobacteria Using PCR. Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin; Springer Nature Singapore, 2023; pp 381–386. doi:10.1007/978-981-99-4514-6_52
• Pawlik-Skowrońska, B.; Bownik, A.; Pogorzelec, M.; Kulczycka, J.; Sumińska, A. First report on adverse effects of cyanobacterial anabaenopeptins, aeruginosins, microginin and their mixtures with microcystin and cylindrospermopsin on aquatic plant physiology: An experimental approach. Toxicon : official journal of the International Society on Toxinology 2023, 236, 107333. doi:10.1016/j.toxicon.2023.107333
• Li, Z.; Zhu, X.; Wu, Z.; Sun, T.; Tong, Y. Recent Advances in Cyanotoxin Synthesis and Applications: A Comprehensive Review. Microorganisms 2023, 11, 2636. doi:10.3390/microorganisms11112636
• Nawaz, T.; Gu, L.; Fahad, S.; Saud, S.; Jiang, Z.; Hassan, S.; Harrison, M. T.; Liu, K.; Khan, M. A.; Liu, H.; El‐Kahtany, K.; Wu, C.; Zhu, M.; Zhou, R. A comprehensive review of the therapeutic potential of cyanobacterial marine bioactives: Unveiling the hidden treasures of the sea. Food and Energy Security 2023, 12. doi:10.1002/fes3.495

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