Advances in synthetic approach to and antifungal activity of triazoles

Scholarly Works

• Mardale, G.; Prodea, A.; Munteanu, A.; Jorgovan, M.; Mardale, S.; Dumitrascu, V. C.; Șoica, C. Benzotriazole in Cancer: A Systematic Review on Preclinical Evidence and Structure–Activity Relationship. Pharmaceuticals 2025, 19, 77. doi:10.3390/ph19010077
• Kant, C.; Mishra, U.; Khan, S.; Kumar, J.; Shukla, M.; Pathak, R. B.; Chopra, I.; Kumar, R.; Kumar, R. Synthesis and Antifungal Activity of 4-Aroyl-5-aryl-1-(thymin-5ʹ-yl)triazoles. Russian Journal of General Chemistry 2025, 95, 3262–3268. doi:10.1134/s1070363225603321
• Guan, T.; Zhou, W.; Gao, Y.; Dong, Q.; Jin, X.; Li, Y.; Xu, Z.; Yu, H.; Dong, J. Apigenin alleviates DFZ-induced cardiac, renal, and intestinal injury in carp by modulating oxidative stress and inflammatory responses. Fish & shellfish immunology 2025, 169, 111054. doi:10.1016/j.fsi.2025.111054
• Martins, N. R. C.; Ribeiro, R. C. B.; Desmarais, M. O. L.; Lourenço, A. L.; da Silva, A. R.; Almeida, T. D. C.; Gonçalves, S. C. G.; Ratcliffe, N. A.; Andrade, I. M. G.; Marins, L. M.; Valle, S. P.; Forezi, L. d. S. M.; Ferreira, V. F.; Nascimento, V.; Castro, H. C.; da Silva, F. d. C. Antifungal profile of menadione tethered to 1H-1,2,3-triazolyl-selenoester: synthesis, in vitro and in silico analyses. Bioorganic & medicinal chemistry 2025, 130, 118380. doi:10.1016/j.bmc.2025.118380
• Nadar, S.; Borkar, M.; Khan, T. Thienopyrimidine: Unveiling the Versatile Potential of a Promising Heterocyclic Scaffold in Drug Discovery. Chemical biology & drug design 2025, 105, e70146. doi:10.1111/cbdd.70146
• Firsova, A. A.; Chernyshov, V. V.; Esaulkova, I. L.; Salakhov, T. L.; Saliev, A. Y.; Ivanov, R. A.; Zarubaev, V. V.; Vatsadze, S. Z. Synthesis of new 4-(5-R-1-phenyl-1H-1,2,4-triazol-3-yl)benzamides. Russian Chemical Bulletin 2025, 74, 1428–1437. doi:10.1007/s11172-025-4639-x
• Quintero-Beltrán, J. S.; Sánchez-Viveros, G.; Chiquito-Contreras, R. G.; Rosas-Saito, G. H.; Ortíz-Castro, R.; Bonilla-Landa, I.; Olivares-Romero, J. L.; Barrera-Méndez, F. Triazoles Nanoencapsulation in Polylactic Acid to Reduce Phytotoxicity in Roots. Journal of the Mexican Chemical Society 2025, 609–620. doi:10.29356/jmcs.v69i3.2254
• Gourkhede, R.; Balakrishna, M. S. Iminophosphorano–phosphine based CuI complexes: utility in 1,3-dipolar azide–alkyne cycloaddition and A3-coupling reaction. New Journal of Chemistry 2025, 49, 7749–7757. doi:10.1039/d5nj00379b
• Larina, L. I.; Semenov, V. A. Stereochemical insights into functionalized triazoles: applications of NMR and quantum chemistry. Russian Chemical Reviews 2025, 94, RCR5160. doi:10.59761/rcr5160
• Chavan, P.; B, M.; Hanamshetty, P. C. One Pot Three Component Synthesis of [1, 2, 4]Triazolo[4, 3-A]Pyrimidine-6-Carboxylate Derivatives as Anti-Microbial, Anti-Cancer Agents and Dft Studies. Elsevier BV 2025. doi:10.2139/ssrn.5148042
• Kumar, D.; Salahuddin; Mazumder, A.; Kumar, R.; Ahsan, M. J.; Yar, M. S.; Abbussalam; Tyagi, P. K.; Chaitanya, M. V. N. L. Pharmacological Evaluation of Bioisosterically Replaced and Triazole- Tethered Derivatives for Anticancer Therapy. Medicinal chemistry (Shariqah (United Arab Emirates)) 2025, 21, 264–293. doi:10.2174/0115734064320533240903062533
• Singh, S.; Kaira, M.; Dey, H.; Pandey, K. C.; Tahlan, S.; Singh, K. Synthetic Methodology, SAR and Pharmacology of Commercialized Preparations Employing 1, 2, 4‐Triazole Analogues. ChemistrySelect 2024, 9. doi:10.1002/slct.202404350
• JAIN, R.; P., P.; KUMAR, B. R. P.; JAIN, V.; G., M.; SHIVAJI, K. S.; KASHAW, S. K.; KOHLI, D. V. DESIGN, SYNTHESIS, IN SILICO STUDIES, AND PHARMACOLOGICAL EVALUATION OF 5-ARYL-4-(CHLOROACETYLAMINO)-3-MERCAPTO-1,2,4-TRIAZOLE DERIVATIVES AS ANTICONVULSANT AGENTS. International Journal of Applied Pharmaceutics 2024, 190–200. doi:10.22159/ijap.2024v16i6.52379
• Kale, J. D.; P.B., A. Review on Thiazolo-triazole as a Promising Anticancer Agent. Asian Journal of Pharmaceutical Research 2024, 270–274. doi:10.52711/2231-5691.2024.00041
• Yadav, S.; Mansi; Misra, N.; Khanna, P.; Khanna, L. Novel 10,11-dihydro-5H-dibenzo[b,f]azepine triazoles hybrids: Synthesis, in vitro antioxidant activity and xanthine oxidase inhibition and computational study. Journal of Molecular Structure 2024, 1312, 138639. doi:10.1016/j.molstruc.2024.138639
• da Cruz, T. P.; da Rocha, M. R.; da Silva, S. M. F.; Moraes, W. B.; Moraes, S. d. P. C. B.; Gazolla, P. A. R.; de Oliveira, M. B.; de Queiroz, V. T.; Teixeira, R. R.; de Oliveira, O. V.; Resende, J. A.; Costa, A. V.; de Jesus Junior, W. C. Fungicidal activity and molecular docking of glycerol‐derived triazole compounds for controlling coffee leaf rust. Plant Pathology 2024, 73, 2453–2465. doi:10.1111/ppa.13986
• Khan, J.; Rani, A.; Aslam, M.; Maharia, R.; Pandey, G.; Nand, B. Exploring triazole-based drugs: Synthesis, application, FDA approvals, and clinical trial updates–A comprehensive review. Tetrahedron 2024, 162, 134122. doi:10.1016/j.tet.2024.134122
• Correa de Moraes, M.; Frassini, R.; Roesch-Ely, M.; Reisdorfer de Paula, F.; Barcellos, T. Novel Coumarin-Nucleobase Hybrids with Potential Anticancer Activity: Synthesis, In Vitro Cell-Based Evaluation, and Molecular Docking. Pharmaceuticals (Basel, Switzerland) 2024, 17, 956. doi:10.3390/ph17070956
• Kale, J. D.; Pravin, B. A. Review on Thiazolo-Triazole as a Promising Anticancer agent. Asian Journal of Research in Chemistry 2024, 169–173. doi:10.52711/0974-4150.2024.00031
• Al Maqbali, A. S.; Al Rasbi, N. K.; Zoghaib, W. M.; Sivakumar, N.; Robertson, C. C.; Shongwe, M. S.; Grzegorzek, N.; Abdel-Jalil, R. J. Stereoselective Asymmetric Syntheses of Molecules with a 4,5-Dihydro-1H-[1,2,4]-Triazoline Core Possessing an Acetylated Carbohydrate Appendage: Crystal Structure, Spectroscopy, and Pharmacology. Molecules (Basel, Switzerland) 2024, 29, 2839. doi:10.3390/molecules29122839

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