An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Scholarly Works

• Samokhin, P.; Flaget, A.; Fernback, J. K.; Lautens, M. Synthesis of Iodinated Semisaturated Heterobicycles via a Temporal Dual Metal-Catalyzed Cycloaddition/Photochemical Carbohalogenation. Journal of the American Chemical Society 2026. doi:10.1021/jacs.6c07102
• Saigal; Sunny, S.; Maingle, M.; Sheeba, L.; Nandy, A.; Seth, K. Brønsted Acid-Catalyzed Three-Component One-Pot Regiospecific Synthesis of Functionalized N-Fused 6-Aryl-N-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-amine and 5-Aroyl-5,7,8,9-tetrahydro-6H-[1,3,4]thiadiazolo[2,3-b]quinazolin-6-one: N- vs C-Nucleophile Control Selectivity Switch between [5,5]- and [5,6]-Membered Bicyclic Cores. The Journal of organic chemistry 2026, 91, 8982–8998. doi:10.1021/acs.joc.6c00683
• Nikpassand, M.; Sheikhmolaei, T.; Fekri, L. Z. Greener synthesis of novel 5-pyrazolyl-pyridine-3-carbonitriles using recyclable Fe 3 O 4 @sP-VNL-TGA magnetic nanocomposite. Phosphorus, Sulfur, and Silicon and the Related Elements 2026, 201, 995–1001. doi:10.1080/10426507.2026.2634187
• Park, S. Catalytic Double Hydrosilylation and Hydroboration of Pyridines and Quinolines. European Journal of Organic Chemistry 2026. doi:10.1002/ejoc.70606
• Singh, A.; Kancherla, R.; Dutta, S.; Dey, A.; Pal, K.; Maity, B.; Kloene, L.; Cavallo, L.; Koenigs, R. M.; Rueping, M. Photoinduzierte palladiumkatalysierte regioselektive Meta‐Alkylierung von Pyridinen. Angewandte Chemie 2026. doi:10.1002/ange.5426146
• Singh, A.; Kancherla, R.; Dutta, S.; Dey, A.; Pal, K.; Maity, B.; Kloene, L.; Cavallo, L.; Koenigs, R. M.; Rueping, M. Photoinduced Palladium-Catalyzed Site-Selective Meta-Alkylation of Pyridines. Angewandte Chemie (International ed. in English) 2026, e5426146. doi:10.1002/anie.5426146
• Al-Assi, G.; Amshawee, A. M.; Ganesan, S.; Al-Hasnaawei, S.; Javahershenas, R.; Surya, C.; Sharma, R.; Sinha, A. Innovative eco-friendly nanocatalyst: CS-NPs/MWCNT@CuFe2O4@Pd for sustainable A3 coupling in the synthesis of 1,3,5-trisubstituted pyrazoles. Journal of Organometallic Chemistry 2026, 1053, 124114. doi:10.1016/j.jorganchem.2026.124114
• Laws, M.; Hind, C. K.; Nahar, K. S.; Clifford, M.; Marsh, C.; Al Adhami, T.; Louis, B.; Xu, M.; Alyemni, S. O.; Haider, S.; Hassan, M.; Gargate, N.; Wand, M. E.; Sutton, J. M.; Rahman, K. M. Designing Antibiotics with Inherent Resistance to Efflux as a Strategy to Revive Discovery against Multidrug-Resistant Pathogens. Journal of medicinal chemistry 2026, 69, 13071–13098. doi:10.1021/acs.jmedchem.6c00060
• Li, J.-W.; Bai, J.; Yang, R.; Luo, M.-J.; Tian, W.-F.; Song, X.-R.; Lu, L.; Xiao, Q. External Photosensitizer-Free, Purple Light-Mediated C-H Alkylation of Heterocycles with Unactivated Alkyl Iodides. The Journal of organic chemistry 2026, 91, 7918–7927. doi:10.1021/acs.joc.6c00585
• Gairola, D.; Parihar, S.; Murarka, S. Iron(III) Ligand‐to‐Metal Charge Transfer Photocatalysis Platform for CH Alkylation of Heterocycles with Feedstock Carboxylic Acids. Advanced Synthesis & Catalysis 2026, 368. doi:10.1002/adsc.70510
• Zou, H.; Yao, J.; Zhou, H. Electrolysis-Promoted Sequence of Oxidation and Cyclization of Propargyl Alcohol and 3-Aminopropanals/Propanones: A One-Pot Construction of Polysubstituted Dihydropyridines. The Journal of organic chemistry 2026, 91, 6951–6955. doi:10.1021/acs.joc.6c00431
• Abdelrheem, D. A.; Khadrawy, S. M.; Ali, M. A. M.; Alkhedhairi, S.; Alkhayl, F. F. A.; Lamsabhi, A. M.; Kamel, E. M. Recent advances in indole-thiazole hybrid scaffolds: synthesis, molecular hybridization, and pharmacological potential. Pharmacological reports : PR 2026, 78, 707–730. doi:10.1007/s43440-026-00856-4
• Lv, C.; Li, S.; Shi, Y.; Chen, H.; Fu, H. Skeletal Editing of Pyridines and Pyrimidines via ANRORC Mechanism. Accounts of chemical research 2026, 59, 1671–1686. doi:10.1021/acs.accounts.6c00077
• Feng, B.; Li, G.; Gao, Y.; Yamamoto, N.; Pink, M.; Peng, Q.; Smith, J. M. Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion‐Directed Regioselectivity. Angewandte Chemie 2026, 138. doi:10.1002/ange.4646822
• Feng, B.; Li, G.; Gao, Y.; Yamamoto, N.; Pink, M.; Peng, Q.; Smith, J. M. Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion-Directed Regioselectivity. Angewandte Chemie (International ed. in English) 2026, 65, e4646822. doi:10.1002/anie.4646822
• Trapasso, G.; Dalla Torre, D.; Artuso, M.; Aricò, F. A Three-Step Route to Functionalized Pyrrole-2,5-Dicarboxylic Acids from Galactaric Acid. ChemSusChem 2026, 19, e202502649. doi:10.1002/cssc.202502649
• Zhang, C.; Wang, M.; Dixneuf, P. H.; Zhang, M. Room-temperature electrochemical hydroxyalkylation of pyridines. Nature communications 2026, 17. doi:10.1038/s41467-026-71858-2
• Haring, M.; Bhattacharya, D.; Xu, P.; Ben Fadhla, D.; Daniliuc, C. G.; Studer, A. Pyridine to Pyridazine Skeletal Editing via CN-to-NN Atom-Pair Swap. Journal of the American Chemical Society 2026, 148, 15404–15409. doi:10.1021/jacs.6c03122
• Li, Y.; Cai, C. Rhodium‐Catalyzed Cascade Annulation of N ‐Nitrosoanilines With Trifluoromethyl‐Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl‐Functionalized Indazole N ‐Oxides. European Journal of Organic Chemistry 2026, 29. doi:10.1002/ejoc.70428
• Woldegiorgis, A. G.; Yuan, Z.; Wu, Q.-Y.; Wang, D.-M.; Ren, F.; Zheng, L.; Wu, Y.; Meng, W.; Wang, P. SPSiP-Enabled Pd-Catalyzed Enantioselective Alkynylamination of Alkenes. Journal of the American Chemical Society 2026, 148, 12526–12534. doi:10.1021/jacs.6c03266

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