Recent advances in transition metal-catalyzed Csp²-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Scholarly Works

• Zhang, Y.; Ma, X.; Sun, W.; Zuo, Z. Photoinduced Selective Hydrodefluorination of Trifluoromethylarenes Enabled by Base-Activated Hantzsch Esters. Organic letters 2026. doi:10.1021/acs.orglett.6c01178
• Andrella, N. O.; Porto, L. L. T. N.; Xu, N.; Ehm, C.; Baker, R. T. Cu‐Catalyzed Tetrafluoroethylation of Aryl Iodides Using "Safe Supply" Tetrafluoroethylene. ChemCatChem 2026, 18. doi:10.1002/cctc.202501655
• Long, T.; Fujioka, K.; Wang, Y.; Zhou, Q.; Zhou, L.; Sun, R.; Zhang, Z. Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study. Organic letters 2025, 27, 12951–12956. doi:10.1021/acs.orglett.5c03024
• Das, S.; Rahaman, S. A.; Das, S.; Pradhan, K.; Jana, R. Organophotoredox-Catalyzed Umpolung Strategy to β-Fluoroamides via Carbamoylative Fluorination of Alkene in Aqueous Medium. The Journal of organic chemistry 2025, 90, 16787–16793. doi:10.1021/acs.joc.5c02084
• Kumawat, S.; Nair, G. N.; Kalevaru, V. N.; Wohlrab, S.; Tarasiuk, T.; Yegorova, T.; Mykhailiuk, P. K.; Natte, K. N-Selective Difluoromethylation of 4-Hydroxyquinolines. Organic letters 2025, 27, 11466–11473. doi:10.1021/acs.orglett.5c03246
• Rzayev, J.; Chang, Z.; Besset, T. Toolbox for emerging fluorinated groups. Comptes Rendus. Chimie 2025, 28, 131–139. doi:10.5802/crchim.370
• Roy, S.; Besset, T. New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(sp3)-F Bond Cleavage. JACS Au 2025, 5, 466–485. doi:10.1021/jacsau.4c01158
• Rueda‐Espinosa, J.; Love, J. A. doi:10.1002/9780470682531.pat1036
• Levet, V.; Ramesh, B.; Wang, C.; Besset, T. C-H Trifluoromethylthiolation of aldehyde hydrazones. Beilstein journal of organic chemistry 2024, 20, 2883–2890. doi:10.3762/bjoc.20.242
• Vincent, É.; Brioche, J. Silver-Catalyzed Carbofluorination of Olefins and α-Fluoroolefins with Carbamoyl Radicals. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202401419. doi:10.1002/chem.202401419
• Huang, Z.-M.; Sun, Y.; Wang, Y.; Wang, X.-W. Unveiling the Selectivity of Ru(II)-Catalyzed C-H Activation for Defluorinative Cyclization of 2-Arylbenzimidazole and Trifluoromethyl Diazo: A DFT Study. The Journal of organic chemistry 2024, 89, 7982–7990. doi:10.1021/acs.joc.4c00629
• Lu, X.-Y.; Huang, R.; Wang, Z.-Z.; Zhang, X.; Jiang, F.; Yang, G.-X.; Shui, F.-Y.; Su, M.-X.; Sun, Y.-X.; Sun, H.-L. Photoinduced Decarboxylative Difluoroalkylation and Perfluoroalkylation of α-Fluoroacrylic Acids. The Journal of organic chemistry 2024, 89, 6494–6505. doi:10.1021/acs.joc.4c00684
• Shigeno, M.; Kiriyama, M.; Izumi, K.; Sasaki, K.; Sasamoto, O.; Nozawa-Kumada, K.; Kondo, Y. LiO-t-Bu/CsF-Mediated Formal Hydrolysis of Trifluoromethyl Arenes. Synthesis 2023, 56, 1438–1448. doi:10.1055/a-2236-0209
• Doche, F.; Poisson, T.; Besset, T. Photocatalytic α-Trifluoromethylthiolation of N-Acyl Amines. ACS Catalysis 2023, 13, 14112–14120. doi:10.1021/acscatal.3c03249
• Zhong, T.; Gu, C.; Li, Y.; Huang, J.; Han, J.; Zhu, C.; Han, J.; Xie, J. Manganese/Cobalt Bimetallic Relay Catalysis for Divergent Dehydrogenative Difluoroalkylation of Alkenes. Angewandte Chemie (International ed. in English) 2023, 62, e202310762. doi:10.1002/anie.202310762
• Zhong, T.; Gu, C.; Li, Y.; Huang, J.; Han, J.; Zhu, C.; Han, J.; Xie, J. Manganese/Cobalt Bimetallic Relay Catalysis for Divergent Dehydrogenative Difluoroalkylation of Alkenes. Angewandte Chemie 2023, 135. doi:10.1002/ange.202310762
• Bernd, J.; Terfort, A. Flow electrosynthesis for efficient O-trifluoromethylation of electron-deficient phenols. Electrochemistry Communications 2023, 154, 107545. doi:10.1016/j.elecom.2023.107545
• Wang, K.; Kong, W. Synthesis of Fluorinated Compounds by Nickel-Catalyzed Defluorinative Cross-Coupling Reactions. ACS Catalysis 2023, 13, 12238–12268. doi:10.1021/acscatal.3c02993
• Monsigny, L.; Doche, F.; Besset, T. Transition-metal-catalyzed C-H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview. Beilstein journal of organic chemistry 2023, 19, 448–473. doi:10.3762/bjoc.19.35
• Wang, F.; Zhang, Q.; Tong, S.; Wang, M. Arene C–H bond trifluoromethylation reactions involving different high valent arylcopper intermediates. SCIENTIA SINICA Chimica 2023, 53, 522–528. doi:10.1360/ssc-2022-0234

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