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Beilstein J. Org. Chem. 2025, 21, 2334–2344, doi:10.3762/bjoc.21.178
Graphical Abstract
Scheme 1: Complanadine natural products and their plausible biosynthesis.
Scheme 2: The Siegel total synthesis of complanadine A enabled by [2 + 2 + 2] cycloadditions.
Scheme 3: The Sarpong total synthesis of complanadine A enabled by a biomimetic strategy and C–H activation.
Scheme 4: The Tsukano total synthesis of complanadine A enabled by Diels–Alder cycloaddition, Heck cyclizatio...
Scheme 5: The Dai total synthesis of complanadine A using single-atom skeletal editing.
Scheme 6: Comparative summary of the four complanadine A total syntheses.