An overview of recent advances in duplex DNA recognition by small molecules

Sayantan Bhaduri,
Nihar Ranjan and
Dev P. Arya

Review
Published 16 May 2018

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1. Graphical Abstract
2. Figure 1: A figure showing the hydrogen bonding patterns observed in (a) duplex (b) triplex and (c) quadruple...
  
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3. Figure 2: (a) Portions of MATα1–MATα2 are shown contacting the minor groove of the DNA substrate. Key arginin...
  
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4. Figure 3: Chemical structures of naturally occurring and synthetic hybrid minor groove binders.
  
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5. Figure 4: Synthetic structural analogs of distamycin A by replacing one or more pyrrole rings with other hete...
  
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6. Figure 5: Pictorial representation of the binding model of pyrrole–imidazole (Py/Im) polyamides based on the ...
  
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7. Figure 6: Chemical structures of synthetic “hairpin” pyrrole–imidazole (Py/Im) conjugates.
  
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8. Figure 7: (a) Minor groove complex formation between DNA duplex and 8-ring cyclic Py/Im polyamide (conjugate ...
  
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9. Figure 8: Telomere-targeting tandem hairpin Py/Im polyamides 23 and 24 capable of recognizing >10 base pairs; ...
  
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10. Figure 9: Representative examples of recently developed DNA minor groove binders.
  
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11. Figure 10: Chemical structures of bisbenzamidazoles Hoechst 33258 and 33342 and their synthetic structural ana...
  
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12. Figure 11: Chemical structures of bisamidines such as diminazene, DAPI, pentamidine and their synthetic struct...
  
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13. Figure 12: Representative examples of recently developed bisamidine derivatives.
  
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14. Figure 13: Chemical structures of chromomycin, mithramycin and their synthetic structural analogs 91 and 92.
  
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15. Figure 14: Chemical structures of well-known naturally occurring DNA binding intercalators.
  
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16. Figure 15: Naturally occurring indolocarbazole rebeccamycin and its synthetic analogs.
  
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17. Figure 16: Representative examples of naturally occurring and synthetic derivatives of DNA intercalating agent...
  
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18. Figure 17: Several recent synthetic varieties of DNA intercalators.
  
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19. Figure 18: Aminoglycoside (neomycin)–Hoechst 33258/intercalator conjugates.
  
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20. Figure 19: Chemical structures of triazole linked neomycin dimers and neomycin–bisbenzimidazole conjugates.
  
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21. Figure 20: Representative examples of naturally occurring and synthetic analogs of DNA binding alkylating agen...
  
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22. Figure 21: Chemical structures of naturally occurring and synthetic analogs of pyrrolobenzodiazepines.
  
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