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Beilstein J. Org. Chem. 2026, 22, 1057–1066, doi:10.3762/bjoc.22.84
Graphical Abstract
Figure 1: Structures of the representative DNA-binding protoberberine alkaloids 1a–c and coralyne (2a).
Scheme 1: Sketch of the proposed combination of covalent oxime ether formation and DNA intercalation with a c...
Scheme 2: Synthesis of alkylated papaverine derivatives 3b–f.
Scheme 3: Synthesis of 13-alkylated coralyne derivatives 2b–d.
Scheme 4: Synthesis of coralyne derivatives 2e–h (Boc: tert-butyloxycarbonyl; DIPEA: N,N-diisopropylethylamin...
Figure 2: Photometric (A) and fluorimetric (B) titration of ct DNA to 2e (c = 10 µM) (B) in BPE buffer (cNa+ ...
Figure 3: A: Influence of 2g on APE1-mediated cleavage of AP-site DNA. The AP–DNA (10 nM) was incubated with ...