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Beilstein J. Org. Chem. 2026, 22, 611–619, doi:10.3762/bjoc.22.47
Graphical Abstract
Figure 1: Design strategy and validation. A) Structure of CAM4066 (1) that served as a model design for the d...
Scheme 1: Synthesis of the key ligand-linker PROTAC precursors. For compound 14, HATU/DIPEA has been used ins...
Scheme 2: (A) Synthesis of final VHL PROTACs; (B) Synthesis of final CRBN PROTACs. Abbreviations: Boc = tert-...
Figure 2: Full structures of final VHL PROTACs 23–26 and CRBN PROTACs 28 and 29.