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Beilstein J. Org. Chem. 2018, 14, 2881–2896, doi:10.3762/bjoc.14.267
Illustration of a PPI modulator (stabilizer or inhibitor) vs a traditional drug target.
Examples of protein–protein interaction modulators in clinical trials or in clinical use.
Small-molecule inhibitors of PPIs in the β-sliding clamp.
Crystal structure of the RU7 (9)-sliding clamp complex (PDB code 3D1G; adapted from Georgescu et al...
Peptidic inhibitors of PPIs in the sliding clamp.
SSB protein–protein interaction inhibitors identified by HTS.
SSB protein–protein interaction inhibitors identified by FBDD.
Examples of molecules that disrupt the ZipA/FtsZ interaction.
Inhibitors of the NusB/NusE interaction.