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Beilstein J. Org. Chem. 2025, 21, 407–411, doi:10.3762/bjoc.21.28
Graphical Abstract
Figure 1: The structures of veliparib and iVeliparib-AP6.
Scheme 1: The synthetic route for iVeliparib-AP6.
Figure 2: Identification of the cryptic impurity of iVeliparib. The UV trace of the initially purified iVelip...
Figure 3: The structures of 6 and 7 and the MS ion extraction traces of 3, 4, 6, and 7 from HPLC analysis of ...
Scheme 2: The conversion of byproduct 6 to 10 to facilitate its removal.
Figure 4: The LUMO and electrostatic charges of thalidomide and its derivatives by DFT calculation at the ωB9...