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Beilstein J. Org. Chem. 2026, 22, 813–820, doi:10.3762/bjoc.22.63
Graphical Abstract
Figure 1: Isatin and representative bioactive spiro-fused 2-oxindoles.
Scheme 1: Reaction of isatin (1) with ʟ-proline (7) [16,17].
Scheme 2: Condensations of isatin with primary [18] and N-methylated diamines [19].
Scheme 3: Catalyzed synthesis of the bis[spiro(quinazoline-oxindole)] derivative 21 [20].
Scheme 4: (a) Ethylenediamine (0.5 equiv), MeOH, reflux, 5 h, 66%; (b) ethylenediamine (2 equiv), EtOH, reflu...
Figure 2: ORTEP representation of bis-spirooxindole 25 (ellipsoids at 50% probability), showing the C2-symmet...
Scheme 5: Proposed mechanism for the formation of 25.
Scheme 6: Synthesis of 30 from 5-methylisatin (29).