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Beilstein J. Org. Chem. 2017, 13, 1204–1211, doi:10.3762/bjoc.13.119
Graphical Abstract
Figure 1: Megasynthases – chemistry and modes of action. a) Products of PKS and FAS megasynthases. b) Reactio...
Figure 2: Compartmentalization of synthesis. a) Surface depiction of fungal FAS (PDB-code: 3hmj) with the upp...
Figure 3: Strategies of megasynthase engineering. a) Mix-and-match approach: A hypothetical chimeric PKS is a...
Figure 4: Preserve-and-adapt approach with FAS. C. ammoniagenes FAS has been engineered in two cooperatively ...